Results 171 to 180 of about 36,778 (260)

Herba Lysimachiae Polysaccharide‐Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22‐Regulated Mitophagy Activation

open access: yesAdvanced Science, Volume 13, Issue 46, 17 August 2026.
HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang   +10 more
wiley   +1 more source

Regional astrocyte dysregulation and altered glymphatic‐related markers in Alzheimer's disease frontal cortex

open access: yesAlzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Astrocyte dysfunction is central to Alzheimer's disease (AD), yet expression patterns of astrocytic markers remain poorly defined. We measured Aquaporin‐4 (AQP4) and glial fibrillary acidic protein (GFAP) in post‐mortem frontal cortex of AD patients and controls across BrainNet Europe (BNE) stages.
Harry Alexopoulos   +8 more
wiley   +1 more source

Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile

open access: yesAnnals of Neurology, Volume 100, Issue 2, Page 255-267, August 2026.
Objectives The pathophysiology of idiopathic intracranial hypertension (IIH) is poorly understood and disease‐specific biomarkers are lacking. We aimed to shed light on IIH pathophysiology and identify disease‐specific biomarkers. Methods This prospective cross‐sectional cohort study included patients with new‐onset IIH and age‐, body mass index‐, and ...
Santosh D. Bhosale   +17 more
wiley   +1 more source

Quantum Phenomena in Molecular and Biological Systems: A Decoherence‐Based Decision Framework With Falsifiable Predictions and a Failure‐Mode Taxonomy

open access: yesAdvanced Physics Research, Volume 5, Issue 8, August 2026.
A physics‐grounded framework based on decoherence timescales (τ_dec vs τ_func), Markovian validity, and falsifiability criteria is applied across molecular systems to distinguish where quantum effects are necessary, marginal, or irrelevant. The analysis integrates quantum chemistry, biological quantum mechanisms, and quantum computing under a unified ...
Sarfaraz K. Niazi
wiley   +1 more source

Evidence for direct and sleep-moderated relationships between aquaporin-4 genetic variants and Alzheimer's disease phenotypes. [PDF]

open access: yesAlzheimers Dement
Porter T   +12 more
europepmc   +1 more source

N6‐Methyladenosine Demethylase FTO Mitigates Cerebral Ischemia–Reperfusion Injury by Suppressing AQP4 Expression

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Mechanism of FTO regulating Hspa1a m6A modification for protection against CIRI. A CIRI leads to a decrease in FTO expression in astrocytes followed by an increase in Hspa1a m6A modification, which promotes HSPA1A degradation. Simultaneously, the NF‐κB pathway becomes activated, and AQP4 expression is upregulated.
Wei Chen   +9 more
wiley   +1 more source

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