Diminished arachidonate 5-lipoxygenase perturbs phase separation and transcriptional response of Runx2 to reverse pathological ventricular remodelingResearch in context [PDF]
EBioMedicine, 2022 Summary: Background: Arachidonate 5-lipoxygenase (Alox5) belongs to a class of nonheme iron-containing dioxygenases involved in the catalysis of leukotriene biosynthesis.
Saiyang Xie +14 more
doaj +2 more sources
Computational prediction of the pathogenic variants of arachidonate 5-lipoxygenase activating protein using Molecular Dynamics simulation. [PDF]
PLoS ONEThe arachidonate 5-lipoxygenase activating protein (ALOX5AP) regulates leukotrienes (LTs) synthesis. LTs are involved in inflammation which is implicated in cardiovascular diseases (CVDs) and stroke.
Mohamed E Elnageeb +12 more
doaj +3 more sources
Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis [PDF]
New England Journal of Medicine, 2004 Leukotrienes are inflammatory mediators generated from arachidonic acid (polyunsaturated n-6 fatty acid) by the enzyme 5-lipoxygenase. Since atherosclerosis involves arterial inflammation, we hypothesized that a polymorphism in the 5-lipoxygenase gene promoter could relate to atherosclerosis in humans and that this effect could interact with the ...
James H, Dwyer +7 more
exaly +5 more sources
Efficacy and Mechanism Evaluation, 2015 Background: The clinical effectiveness of intermittent montelukast for wheeze in young children is unclear. Previous work has been equivocal. Variation in copy numbers of the specificity protein 1-binding motif in the arachidonate 5-lipoxygenase (ALOX5 ...
Chinedu Nwokoro +13 more
doaj +2 more sources
Irisin regulates lipid metabolism and ferroptosis in ovarian cancer cells by modulating the ALOX5-5-HETE-PD-L1 axis [PDF]
Scientific ReportsThis study investigates the role of arachidonate 5-lipoxygenase (ALOX5) in upregulating programmed death-ligand 1 (PD-L1) expression via its metabolite 5-hydroxyeicosatetraenoic acid (5-HETE) in ovarian cancer cells, and explores the effects on lipid ...
Huichun Cai, Caiyun Huang, Zhenwei Zhang
doaj +2 more sources
Chilling injury mechanism in the immature oocytes of zebrafish (Danio rerio) [PDF]
The Journal of Reproduction and DevelopmentImmature zebrafish oocytes are sensitive to chilling, and their survival is markedly reduced by exposure to 0°C. In the present study, we investigated the involvement of cold-sensitive channels and lipid mediators in chilling injury in immature zebrafish ...
Yanuar ACHADRI +4 more
doaj +2 more sources
Prediction of pEC50(M) and molecular docking study for the selective inhibition of arachidonate 5-lipoxygenase [PDF]
The Ukrainian Biochemical Journal, 2021 Arachidonate 5-lipoxygenase (ALOX5) is considered a prime target for drug discovery in the area of liver fibrosis, rheumatoid arthritis, atherosclerosis, cancer and asthma.
N. R. Das, P. G. R. Achary
doaj +1 more source
Role of the route of leukotrienes in an experimental model of oral mucositis induced by 5-fluorouracil [PDF]
Acta Cirúrgica Brasileira, 2017 Purpose: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. Methods: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i.p., on days 1 and 2, respectively, and with ...
Viviane Carvalho da Silva +7 more
doaj +2 more sources
Protective Effect of Co Q10 and Candesartan on Bleomyycin Induced Lung Fibrosis in Rats
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Fibrosis of the lungs is the final phase of many lung illnesses. Its characterized by excessive matrix production leading to the normal lung architecture destruction and eventually death.
Fatima Mohammad Saeed Mahdi +2 more
doaj +1 more source
ALOX5 (arachidonate 5-lipoxygenase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on ALOX5 (arachidonate 5-lipoxygenase), with data on DNA, on the protein encoded, and where the gene is implicated.
S Banerjee, S Tuncay
openaire +1 more source