Results 1 to 10 of about 5,194 (173)
5‐lipoxygenase‐activating protein is an arachidonate binding protein [PDF]
FEBS Letters, 1993 5‐Lipoxygenase‐activating protein (FLAP) is an 18‐kDa integral membrane protein which is essential for cellular leukotriene (LT) synthesis, and is the target of LT biosynthesis inhibitors. However, the mechanism by which FLAP activates 5‐LO has not been determined.
Joseph A. Mancini +8 more
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ALOX5 (arachidonate 5-lipoxygenase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on ALOX5 (arachidonate 5-lipoxygenase), with data on DNA, on the protein encoded, and where the gene is implicated.
Sreeparna Banerjee, Seda Tuncay Cagatay
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Arachidonate 5-Lipoxygenase Variants in Atherosclerosis, Obesity, and Bone Traits [PDF]
Circulation Research, 2006 To the Editor: I write regarding publications by Mehrabian et al1,2 appearing in Circulation Research and a subsequent publication by Kuhn et al3 appearing in Arteriosclerosis, Thrombosis, and Vascular Biology . The key implication from the combination of these reports was that amino acid substitutions in arachidonate 5-lipoxygenase (ALOX5) could ...
Malcolm A. Lyons
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Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis [PDF]
New England Journal of Medicine, 2003 Leukotrienes are inflammatory mediators generated from arachidonic acid (polyunsaturated n-6 fatty acid) by the enzyme 5-lipoxygenase. Since atherosclerosis involves arterial inflammation, we hypothesized that a polymorphism in the 5-lipoxygenase gene promoter could relate to atherosclerosis in humans and that this effect could interact with the ...
James H. Dwyer +7 more
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Japanese Journal of Pharmacology, 2000 To investigate the cellular sources of arachidonate metabolites during asthma, in vitro productions of thromboxane (TX) B2, prostaglandin (PG) D2, leukotriene (LT) B4 and cysteinyl (Cys) LTs from guinea pig eosinophils and macrophages simultaneously stimulated with the Ca ionophore A23187 were investigated.
Takeshi Nabe +3 more
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Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis [PDF]
New England Journal of Medicine, 2004 Hooman Allayee, Aldons J Lusis
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Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells [PDF]
Proceedings of the National Academy of Sciences, 1998 Diets high in fat are associated with an increased risk of prostate cancer, although the molecular mechanism is still unknown. We have previously reported that arachidonic acid, an omega-6 fatty acid common in the Western diet, stimulates proliferation of prostate cancer cells through production of the 5-lipoxygenase metabolite, 5-HETE (5 ...
J. J. Ghosh, Charles E. Myers
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Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice [PDF]
Journal of Lipid Research, 2008 Esther Titos +2 more
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