Results 91 to 100 of about 16,216 (223)

Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Ruchi Biswas, Jamie Moore Fried, Maria A. Curotto de Lafaille   +2 more
wiley   +1 more source

Functional characterization of a novel arachidonic acid 12S-lipoxygenase in the halotolerant bacterium Myxococcus fulvus exhibiting complex social living patterns [PDF]

, 2018
Lipoxygenases are lipid peroxidizing enzymes, which frequently occur in higher plants and mammals. These enzymes are also expressed in lower multicellular organisms but here they are not widely distributed.
Blum, Maximilian, Goloshchapova, Kateryna, Heydeck, Dagmar, Kuhn, Hartmut, Stehling, Sabine   +4 more
core   +1 more source

Trained Immunity and Cardiovascular Risk: An Immunological Perspective

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Systemic inflammation is a key driver of atherogenesis and its complications. While anti‐inflammatory therapies targeting pathways such as IL‐1β and IL‐6 have shown promise in established atherosclerotic cardiovascular disease (ASCVD), potential systemic effects raise concerns about immune suppression and infection, underscoring the need for ...
Katherine A. Boden, Jason Chai, Tafadzwa T. J. Kufazvinei, Robin P. Choudhury   +3 more
wiley   +1 more source

Role of lipoxygenase products in the effects of angiotensin II in the isolated aorta and perfused heart of the rat

Mediators of Inflammation, 1995
The objective of this study was to determine whether arachidonate metabolites are involved in the vasoconstrictive effects of angiotensin II in rats. In the isolated perfused heart, dexamethasone (4 mg/kg) significantly suppressed the maximal decreases ...
J. P. M. Dam, E. van den Worm, W. Vleeming, M. J. Post, A. J. Porsius, J. Wemer   +5 more
doaj   +1 more source

Evaluation of Phenoxybenzamine in the CFA Model of Pain following Gene Expression Studies and Connectivity Mapping [PDF]

, 2010
Background We have previously used the rat 4 day Complete Freund's Adjuvant (CFA) model to screen compounds with potential to reduce osteoarthritic pain.
Meiping Chang, Sarah Smith, Andrew Thorpe, Michael J Barratt, Farzana Karim   +4 more
core   +1 more source

Network Pharmacology Combined With Gut Microbiome and Serum Metabolomics Reveals the Therapeutic Mechanisms of Hydroxysafflor Yellow A in Diabetic Kidney Disease

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Diabetic kidney disease (DKD) is a severe complication of diabetes, primarily driven by chronic inflammation, oxidative stress, and gut microbiota dysbiosis. Hydroxysafflor yellow A (HSY), a bioactive compound derived from Carthamus tinctorius L., demonstrates promising renoprotective effects.
Pingping Wang, Xinyu Liu, Wen Sun, Xueyun Dong, Jiajun Tan, Min Chen, Jiayuan He, Asmaa Ali, Liang Wu, Keke Shao, Huantian Cui   +10 more
wiley   +1 more source

Gastroprotective Effect of Cochinchina momordica Seed Extract in Nonsteroidal Anti-Inflammatory Drug-Induced Acute Gastric Damage in a Rat Model

Gut and Liver, 2014
Background/AimsThe major compounds of Cochinchina momordica seed extract (SK-MS10) include momordica saponins. We report that the gastroprotective effect of SK-MS10 in an ethanol-induced gastric damage rat model is mediated by suppressing proinflammatory
doaj   +1 more source

Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis [PDF]

, 2018
Background: Adapted ketogenic diet (AKD) and caloric restriction (CR) have been suggested as alternative therapeutic strategies for inflammatory, hyperproliferative and neurodegenerative diseases.
Bock, Markus, Karber, Mirjam, Kuhn, Hartmut   +2 more
core   +2 more sources

Hemodynamic role of arachidonate 12- and 5-lipoxygenases in nephrotoxic serum nephritis

Kidney International, 1993
The role of arachidonate 12- and 5-lipoxygenation eicosanoids in mediating acute changes in renal hemodynamics was assessed in nephrotoxic serum nephritis (NSN) in the rat. Following a single intravenous injection of nephrotoxic serum (NTS), significant decrements in glomerular filtration rate (GFR) and renal blood flow (RBF) occurred at one hour, and ...
Wu, Sheng-Hua, Bresnahan, Barbara A., Lianos, Elias A.   +2 more
openaire   +2 more sources

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source