Results 21 to 30 of about 5,194 (173)

Expression of mRNA for phospholipase A(2), cyclooxygenases, and lipoxygenases in cultured human umbilical vascular endothelial and smooth muscle cells and in biopsies from umbilical arteries and veins [PDF]

, 1998
Arachidonic acid (AA) is released by phospholipase A(2) (PLA(2)) and then converted into vasoactive and inflammatory eicosanoids by cyclooxygenases (COX) and lipoxygenases (LOX).
Carlsson, Maria, Gidlöf, Anders, Sirsjö, Allan, Söderkvist, Peter, Uhl, Eberhard, Öst, Martin   +5 more
core   +1 more source

Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet. [PDF]

, 2015
Maternal diet during pregnancy influences the later life reproductive potential of female offspring. We investigate the molecular mechanisms underlying the depletion of ovarian follicular reserve in young adult females following exposure to obesogenic ...
Aiken, Catherine E, Dearden, Laura, Ozanne, Susan E, Penfold, Naomi C, Tarry-Adkins, Jane L   +4 more
core   +2 more sources

The chronic myeloid leukemia stem cell: stemming the tide of persistence [PDF]

, 2017
Chronic myeloid leukaemia (CML) is caused by the acquisition of the tyrosine kinase BCR-ABL1 in a haemopoietic stem cell (HSC), transforming it into a leukaemic stem cell (LSC) that self-renews, proliferates and differentiates to give rise to a ...
Holyoake, Tessa L., Vetrie, David
core   +1 more source

Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: nutritional implications for cardiometabolic diseases [PDF]

, 2020
Prospective observational studies support the use of long-chain omega-3 polyunsaturated fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; however, randomised controlled trials, have often reported neutral findings ...
Abdelhamid, Abdelhamid, Al-Hilal, Allayee, Armstrong, Aung, Baylin, Bhatt, Bjermo, Bosch, Bowman, Brown, Burdge, Burr, Cannon, Chavez, Cho, Chowdhury, Colazzo, Contreras, Cormier, Das, Dayton, de Toro-Martin, Demetz, Dorris, Draisma, Dumont, Dumont, Dupuis, Dwyer, Farvid, Fezeu, Floegel, Floegel, Forouhi, Frantz, Fretts, Fumagalli, Gabbs, Gammelmark, Gammelmark, Gillingham, Gol, Gromovsky, Guan, Hamley, Harris, Harris, Harris, Heemskerk, Hellstrand, Hilvo, Hooper, Hu, Illig, Imamura, Innes, Jakobsen, Jamieson, Johnson, Juan, Jäger, Jäger, Keaney, Kemp, Kromhout, Kröger, Kröger, Lankinen, Lemaitre, Leren, Li, Ligthart, Liu, Lu, Mahajan, Maki, Manson, Marklund, Marklund, McManus, Micha, Miettinen, Moltó-Puigmartí, Monk, Monteiro, Mozaffarian, Mozaffarian, Mozaffarian, Nelson, Nicholls, O'Neill, Pan, Piepoli, Powell, Ramsden, Ramsden, Ramsden, Ratnayake, Rimm, Risérus, Rizos, Roncaglioni, Rosqvist, Ross, Sarwar, Serhan, Simopoulos, Sioen, Siscovick, Skeaff, Skulas-Ray, Smith, Standl, Stephensen, Stoffel, Sudmant, Sun, Takkunen, Trumbo, Turpeinen, Wang, Wang, Wei, White, Willer, Woodhill, Wu, Wu, Wu, Xue, Yamagishi, Ye, Yokoyama, Yuan, Zhang   +136 more
core   +1 more source

Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase. [PDF]

, 2019
Human platelet ALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to more thoroughly understand how it positions the substrate and achieves nearly perfect regio- and ...
Aleem, Ansari Mukhtar, Alvarez, Gabriella, Deschamps, Joshua, Holman, Theodore, Jacobson, Matthew P, Kalyanaraman, Chakrapani, Tena, Jennyfer, Tsai, Wan-Chen   +7 more
core   +2 more sources

Convergent Oxygenation of Arachidonic Acid by 5-Lipoxygenase and Cyclooxygenase-2 [PDF]

Journal of the American Chemical Society, 2005
5-Lipoxygenase and cyclooxygenase-2 (COX-2) initiate the biosynthesis of distinct families of mediators from arachidonic acid (leukotrienes and prostaglandins, respectively) and are each the target of anti-inflammatory medications. Here we show that the product of 5-lipoxygenase, 5S-hydroxyeicosatetraenoic acid, is selectively and efficiently triply ...
Claus, Schneider, William E, Boeglin, Huiyong, Yin, Donald F, Stec, Markus, Voehler   +4 more
openaire   +2 more sources

Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. [PDF]

, 2009
Pharmacological suppression of leukotriene biosynthesis by inhibitors of 5-lipoxygenase (5-LO) is a strategy to intervene with inflammatory and allergic disorders.
BÜHRING U, KARG EM, LUDERER S, NORTHOFF H, PERGOLA C, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, TROSCHÜTZ R, WERZ O.   +8 more
core   +1 more source

Inhibition of arachidonate 5-lipoxygenase by phenolic compounds.

Chemical and Pharmaceutical Bulletin, 1986
Some cinnamoyl-β-phenethylamine derivatives, gingerols, diarylheptanoids and acyldopamines were tested for their inhibitory effects on the 5-lipoxygenase of RBL-1 cells. Compounds containing a catechol group together with a lipophilic group strongly inhibited 5-lipoxygenase.
S, Iwakami, M, Shibuya, C F, Tseng, F, Hanaoka, U, Sankawa   +4 more
openaire   +3 more sources

Eicosanoids in skin inflammation. [PDF]

, 2012
NoEicosanoids play an integral part in homeostatic mechanisms related to skin health and structural integrity. They also mediate inflammatory events developed in response to environmental factors, such as exposure to ultraviolet radiation, and ...
Agarwal, Albanesi, Andersen, Andoh, Andoh, Anna Nicolaou, Baer, Baer, Baron, Bergers, Black, Boeglin, Boguniewicz, Boyce, Brash, Bray, Bryniarski, Burke, Burr, Calder, Calder, Carlson, Carsberg, Chapkin, Chen, Chene, Church, Colombe, Crespy, De Nucci, Dennis, Doepping, Du, Epp, Fincham, Fisher, Fogh, Fogh, Fogh, Ford-Hutchinson, Gledhill, Goetzl, Gonzalez, Grabbe, Grabbe, Grant, Gresham, Grundmann, Gueck, Hansen, Harris, Honda, Honda, Honma, Hruza, Ikai, Ikai, Ikai, Janssen-Timmen, Jisaka, Judson, Judson, Kanda, Keeney, Keeney, Kolgen, Konger, Kragballe, Kragballe, Krieg, Kudo, Kuhn, Ladd, Leong, Levy, Lowes, Lu, Lu, Martin, Masoodi, Massey, Matsushima, Mayer, Mayser, McCusker, McDaniel, Millard, Miller, Miller, Milne, Muller, Nakajima, Narayanan, Nichols, Nicolaou, Nicolaou, Oka, Oyoshi, Parekh, Pentland, Pietrzak, Pilkington, Proksch, Rhodes, Rhodes, Ricketts, Rijken, Ruzicka, Sato, Satoh, Schafer, Schweiger, Scott, Scott, Scott, Serhan, Serhan, Shimura, Singh, Sjursen, Spanbroek, Stark, Straus, Sugimoto, Tai, Takeda, Ueno, Watanabe, Weber, Xi, Yoo, Zheng, Zhou, Ziboh, Ziboh, Ziboh, Ziboh, Ziboh, Zulfakar, Zuo   +139 more
core   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source