Results 21 to 30 of about 16,216 (223)
Modulation of Cox-1, 5-, 12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases. [PDF]
, 2014 Acanthus mollis (Acanthaceae), Achillea ligustica, Artemisia arborescens and Inula viscosa (Asteraceae) are used in Southern Italy against psoriasis and other skin diseases that occur with an imbalanced production of eicosanoids.
Amenta +26 more
core +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundThe arachidonate 5‐lipoxygenase enzyme plays a crucial role in mediating inflammation to maintain homeostasis, yet certain allelic variants of the 5‐lipoxygenase gene, ALOX5, may increase risk of atherosclerosis and coronary heart disease (CHD).
Michael Y. Tsai +6 more
doaj +1 more source
BMC Research Notes, 2020 Objective The arachidonate 5-lipoxygenase (ALOX5) pathway has been investigated in diverse chronic inflammatory diseases including metabolic disorders. Recently, the ALOX5 polymorphism rs4987105 was identified to confer susceptibility to type 2 diabetes ...
Xi Li +8 more
doaj +1 more source
Altered eicosanoid production and phospholipid remodeling during cell culture[S]
Journal of Lipid Research, 2018 The remodeling of PUFAs by the Lands cycle is responsible for the diversity of phospholipid molecular species found in cells. There have not been detailed studies of the alteration of phospholipid molecular species as a result of serum starvation or ...
Toshiaki Okuno +8 more
doaj +1 more source
Identification of transcription factor binding sites in promoter databases [PDF]
, 2011 Transcription factors (TFs) are the proteins which regulates the expression of their target genes either in a positive or negative manner. TFs realize this task by binding to a specific DNA sequence contained in promoter regions, via their DNA binding ...
Dağ, Uğur +5 more
core +1 more source
Fatty acid binding proteins stabilize leukotriene A4
Journal of Lipid Research, 2004 Leukotriene A4 (LTA4) is a chemically reactive conjugated triene epoxide product derived from 5-lipoxygenase oxygenation of arachidonic acid. At physiological pH, this reactive compound has a half-life of less than 3 s at 37°C and ∼40 s at 4°C ...
Jennifer S. Dickinson Zimmer +3 more
doaj +1 more source
Production of inflammatory mediators by human macrophages obtained from ascites [PDF]
, 1994 Ascites is a readily available source of human macrophages (Mø), which can be used to study Mø functions in vitro. We characterized the mediators of inflammation produced by human peritoneal Mø (hp-Mø) obtained from patients with portal hypertension and ...
Bonta, I.L. +5 more
core +1 more source
n-3系脂肪散を強化した食事療法が有効と考えられた肺気腫の一例 [PDF]
, 1998 An effective treatment for the advanced stages of chronic obstructive pulmonary disease (COPD) has not been established yet. We report our recent experience of one patient with pulmonary emphysema treated by dietary supplementation of n-3 fatty acid for ...
Ashida, Kozo +7 more
core +1 more source
Cell type-dependent activation of 5-lipoxygenase by arachidonic acid [PDF]
Journal of Leukocyte Biology, 2003 Abstract 5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of proinflammatory leukotrienes. We show that stimulation of polymorphonuclear leukocytes (PMNL), rat basophilic leukemia (RBL)-1, or transfected HeLa cells with arachidonic acid (AA) caused prominent 5-LO product formation that coincided with the activity of ...
Eva, Bürkert +4 more
openaire +2 more sources
The role of vitamin C in the gene expression of oxidative stress markers in fibroblasts from burn patients [PDF]
Acta Cirúrgica Brasileira, 2018 Purpose: To assess the action of vitamin C on the expression of 84 oxidative stress related-genes in cultured skin fibroblasts from burn patients. Methods: Skin samples were obtained from ten burn patients.
Jessica Bonucci +5 more
doaj +1 more source