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Mammalian arachidonate 15-lipoxygenases
Prostaglandins and Other Lipid Mediators, 2002Hartmut Kuhn, Matthias Walther
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Epidermal arachidonate lipoxygenase
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1983Guinea pig skin was found to display a high lipoxygenase activity, evidenced by the formation of a hydroxyeicosatetraenoic acid (HETE) from exogenous [14C]arachidonic acid. The lipoxygenase activity was localized to the epidermal layer of the skin, was completely inhibited by eicosatetraynoic acid (ETYA) and slightly enhanced by indomethacin ...
T, Ruzicka, A, Vitto, M P, Printz
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Arachidonate 8(S)-lipoxygenase
Prostaglandins & Other Lipid Mediators, 2002The recently identified mouse 8(S)-lipoxygenase almost exclusively directs oxygen insertion into the 8(S) position of arachidonic acid and, with lower efficiency, into the 9(S) position of linoleic acid. The protein of 677 amino acids displays 78% sequence identity to human 15(S)-lipoxygenase-2 which is considered to be its human orthologue.
Gerhard, Fürstenberger +2 more
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Arachidonate 12-Lipoxygenase Isozymes
1999A lipoxygenase is an enzyme which incorporates one molecule of oxygen into arachidonic acid or other polyunsaturated fatty acids producing hydroperoxy acids with a conjugated diene system. Enzymes oxygenating at the positions 5, 8, 12 and 15 of arachidonic acid and producing the corresponding hydroperoxy eicosatetraenoic acid (HpETE) have been isolated
S, Yamamoto +3 more
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Journal of Lipid Mediators and Cell Signalling, 1995
In this article, it has been attempted to review data primarily on the activation of human 5-lipoxygenase, in vitro and in the cell. First, structural properties and enzyme activities are described. This is followed by the activating factors: Ca2+, membranes, ATP, and lipid hydroperoxide.
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In this article, it has been attempted to review data primarily on the activation of human 5-lipoxygenase, in vitro and in the cell. First, structural properties and enzyme activities are described. This is followed by the activating factors: Ca2+, membranes, ATP, and lipid hydroperoxide.
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Arachidonate lipoxygenase in blood platelets
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1975Abstract Blood platelets contain a lipoxygenase which converts eicosapolyenoic acids with at least two cis double bonds at the 8- and 11-position into l -12-hydroperoxy acids. The enzyme responsible is found in the supernatant of broken platelets.
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Role of arachidonic acid lipoxygenase pathway in Asthma
Prostaglandins & Other Lipid Mediators, 2022The arachidonic acid (AA) metabolism pathways play a key role in immunological response and inflammation diseases, such as asthma, etc. AA in cell membranes can be metabolized by lipoxygenases (LOXs) to a screen of bioactive substances that include leukotrienes (LTs), lipoxins (LXs), and eicosatetraenoic acids (ETEs), which are considered closely ...
Yacan, Luo +7 more
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Lipoxygenase Metabolism of Arachidonic Acid in Brain
Journal of Neurochemistry, 1985Abstract: When blood‐free mouse brain slices were incubated with exogenous radiolabeled arachidonic acid, gas chromatography/mass spectrometry confirmed that the major radioactive lipoxygenase enzyme product of arachidonic acid was 12‐hydroxy‐5,8,10,14‐eicosatetraenoic acid (12‐HETE), with lesser amounts of 5‐hydroxy‐6,8,11,14‐eicosatetraenoic acid ...
S A, Adesuyi +3 more
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Identification and characterization of an arachidonate 11R-lipoxygenase
Archives of Biochemistry and Biophysics, 200611R-Lipoxygenase (11R-LOX) activity has been detected in several marine invertebrates, and here we report the first cloning and expression of the enzyme. The cDNA encoding a protein of 77kDa was isolated by RT-PCR from the soft coral Gersemia fruticosa and expressed in Escherichia coli.
Monika, Mortimer +4 more
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Inhibition of arachidonate lipoxygenase by ketotifen
Biochemical Society Transactions, 1988Ketotifen is commonly used for the prophylactic treatment of bronchial asthma. There is evidence that ketotifen antagonizes 5-hydroxytryptamine and acts by preventing mediator release from mast cells and protects asthmatic patients from allergen and or histamine-induced bronchoconstriction (Girard & Cuevas, 1977; Wuethrich et al., 1978).
SHEIKH A. SAEED +3 more
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