Results 141 to 150 of about 3,184 (177)
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Nuclear Import of Arachidonate 5-Lipoxygenase
2001Leukotrienes are lipid messenger molecules that are secreted by leukocytes to orchestrate a rapid and prolonged immune response. The enzyme 5-lipoxygenase catalyzes the rate-limiting first two steps in the synthesis of leukotrienes from arachidonic acid.
T G, Brock, A M, Healy
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Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis
New England Journal of Medicine, 2004Leukotrienes are inflammatory mediators generated from arachidonic acid (polyunsaturated n-6 fatty acid) by the enzyme 5-lipoxygenase. Since atherosclerosis involves arterial inflammation, we hypothesized that a polymorphism in the 5-lipoxygenase gene promoter could relate to atherosclerosis in humans and that this effect could interact with the ...
James H, Dwyer +7 more
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Platelet-Type Arachidonate 12-Lipoxygenase
1996In human platelets arachidonic acid is released from membrane phospholipids by the catalysis of phosopholipase A2, and then oxygenated either by cyclooxygenase or by 12-lipoxygenase. It is well known that the cyclooxygenase pathway leads to the synthesis of pro-aggregatory and vasoconstrictive thromboxane A2.
M, Nakamura +5 more
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The Airway Epithelium and Arachidonic Acid 15-Lipoxygenase
American Review of Respiratory Disease, 1991Abstract Pulmonary epithelial cells may be primarily responsible for initiating or regulating inflammatory responses in the airways, in part by releasing chemical mediators. Among the most potent mediators of inflammation are the lipoxygenase metabolites of arachidonic acid, including the leukotrienes and other mono and ...
E, Sigal, J A, Nadel
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Flavonoids: Potent inhibitors of arachidonate 5-lipoxygenase
Biochemical and Biophysical Research Communications, 1983Various flavonoids were found to be relatively selective inhibitors of arachidonate 5-lipoxygenase which initiates the biosynthesis of leukotrienes with the activity of slow reacting substance of anaphylaxis. Cirsiliol (3',4',5-trihydroxy-6,7-dimethoxyflavone) was most potent, and the enzyme partially purified from rat basophilic leukemia cells was ...
T, Yoshimoto +4 more
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Arachidonate 12-lipoxygenases with reference to their selective inhibitors
Biochemical and Biophysical Research Communications, 2005Lipoxygenase is a dioxygenase recognizing a 1-cis,4-cis-pentadiene of polyunsaturated fatty acids. The enzyme oxygenates various carbon atoms of arachidonic acid as a substrate and produces 5-, 8-, 12- or 15-hydroperoxyeicosatetraenoic acid with a conjugated diene chromophore.
Shozo, Yamamoto +7 more
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A particulate arachidonate lipoxygenase in human blood platelets
Biochemical and Biophysical Research Communications, 1977Abstract The microsomal fraction of human platelets contains a lipoxygenase activity in addition to the thromboxane-synthesizing activity. The enzymatic activity was stimulated by tryptophan, but inhibited by catecholamine, methemoglobin, and hydroquinones.
P P, Ho, C P, Walters, H R, Sullivan
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Arachidonate 5-lipoxygenase and its new inhibitors
Journal of Allergy and Clinical Immunology, 1984The 5-lipoxygenases of guinea pig peritoneal polymorphonuclear leukocytes and of rat basophilic leukemia cells have been solubilized, purified partially by affinity chromatography, and shown to convert arachidonic acid principally to 5-hydroperoxy-6,8,11,14- eicosatetraenoic acid.
S, Yamamoto +4 more
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Arachidonate Lipoxygenase Products and Psoriasis
1985Psoriasis is a common skin disease that, in many cases, appears to be genetically determined. Lesional skin is characterized by epidermal proliferation and inflammatory changes, of which intraepidermal neutrophil infiltration is a consistent finding and one of the earliest abnormalities seen in developing lesions (Chowaniec et al., 1981). Psoriasis may
Richard D. Camp +2 more
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Arachidonate lipoxygenase activity in human fetal lung
European Journal of Pharmacology, 1982The results are suggestive of the presence of lipoxygenase activity in human fetal lung. Since human fetal lung produces PG's and since the lipoxygenase products, HETE and its labile hydroperoxy precursor, HPETE have been proposed as potentially important mediators for many biological activities, the formation of these compounds including PGs early in ...
Saeed, Sheikh A., Mitchell, Murray D.
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