Results 191 to 200 of about 194,523 (350)

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Prevotella copri alleviates diarrhea in weaning piglets through gut microbiota modulation and arachidonic acid-AHR-NRF2 pathway activation. [PDF]

J Anim Sci Biotechnol
Lan C, Ren W, Wu A, Yu B, He J, Luo Y, Chen D.   +6 more
europepmc   +1 more source

Involvement of Group VI Ca2+-independent Phospholipase A2 in Protein Kinase C-dependent Arachidonic Acid Liberation in Zymosan-stimulated Macrophage-like P388D1 Cells [PDF]

, 1999
Satoshi Akiba, Shingo Mizunaga, Keisuke Kume, Misako Hayama, Takashi Sato   +4 more
openalex   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

KIF18A induces the EMT process of hepatoma cells through the 5-LOX-dependent arachidonic acid pathway. [PDF]

PLoS One
Wang Y, Cai T, Chen Y, Liu W, Liu B, Zhao X, Wang Y, Cao J, Zeng Q.   +8 more
europepmc   +1 more source

An agent that releases basophil and mast cell histamine but blocks cyclooxygenase and lipoxygenase metabolism of arachidonic acid inhibits immunoglobulin E-mediated asthma in rhesus monkeys

, 1981
Roy Patterson, Jacob J. Pruzansky, Kathleen E. Harris   +2 more
openalex   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Pre-activation of T cell immunity potentiates ferroptotic cell death through arachidonic acid hybridized nanovesicles. [PDF]

J Nanobiotechnology
Lyu Q, Liu C, Li S, Shan D, Han H, Wang L, Xu H.   +6 more
europepmc   +1 more source

Tumor‐Derived Prostaglandin E2 Promotes Colorectal Cancer Progression by Inducing N2‐Type TAN Polarization

Cancer Science, EarlyView.
We demonstrated that PGE2 released from LDs in CRC cells plays important roles in N2‐type TANs polarization. PGE2 enters neutrophils through its receptor EP2/EP4 to stimulate ROS‐mediated FOXO3a methylation, thereby increasing the polarization of N2‐type TANs.
Yue Han, Wen Chen, Bin Zhang, Shuang Wang   +3 more
wiley   +1 more source

Tumoral ALOX5 mediated arachidonic acid metabolism regulates immune response in non-small cell lung cancer. [PDF]

Cell Oncol (Dordr)
Gao Y, Xia Y, Li J, Lai Y, Yin S, Lin J, Yu D, Huang S, Lu F, Wang W, Chu Q.   +10 more
europepmc   +1 more source