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Interactions of zinc and arachidonic acid
Prostaglandins and Medicine, 1981To probe the interaction of zinc with polyunsaturated fatty acids we have studied the effect of zinc on the cooxygenation of ferrous iron and arachidonic acid. Zinc inhibited the process of cooxygenation in a concentration dependent fashion. Further evaluation of the interaction of zinc and arachidonic acid gave spectroscopic evidence that zinc, oxygen
D A, Peterson +4 more
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Preparation of deuterated arachidonic acid
Prostaglandins, 1981Publisher Summary It is reported preparation of [ 2 H 8 ]arachidonic acid from the precursor tetraacetylene eicosatetraynoic procedures gave rise to substantial double-bond isomerization and isotopic scrambling, leading to mixtures that yielded after purification only small quantities of the desired product.
D F, Taber, M A, Phillips, W C, Hubbard
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Arachidonic acid aggregates neutrophils
Inflammation, 1979Arachidonic acid, but not several structurally similar fatty acids, stimulated neutrophils in suspension to aggregate; this effect was blocked by 5, 8, 11, 14-eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism. Analagous to platelets, arachidonate may be a precursor of active metabolites which mediate neutrophil responses.
J T, O'Flaherty +3 more
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Biologic Importance of Arachidonic Acid
Archives of Internal Medicine, 1981The most abundant prostaglandin precursor is arachidonic acid (or its precursor, linoleic acid). The isolation and identification of prostaglandin compounds in a particular tissue, knowledge of the biologic properties of these compounds, and the use of readily available inhibitors of the prostaglandin pathway by aspirin-like drugs constitute the main ...
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Arachidonic acid and eicosanoid release
Journal of Immunological Methods, 1994The major techniques for the study and determination of eicosanoid metabolism in eukaryotic cells will be described. These techniques include the determination of free arachidonic acid and its metabolites in biological fluids and cell media by immunochemical techniques (RIA, ELISA) and by HPLC.
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Psoriasis and the arachidonic acid cascade
Journal of Dermatological Science, 1999Arachidonic acid (5.8,11,14-eicosatetraenoic acid C20:4, n-6) is released from the cell membrane by the action of phospholipases on membrane phospholipids. Metabolites of arachidonic acid, which are generically termed eicosanoids, including prostaglandins, thromboxane, leukotrienes and hydroxyeicosatetraenoic acids, have been implicated as mediators or
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Metabolism of Arachidonic Acid
Annals of the New York Academy of Sciences, 1988S, Moncada, E A, Higgs
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Metabolites of arachidonic acid
Clinical Reviews in Allergy, 1983W F, Stenson, C W, Parker
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Effects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease
International Journal of Molecular Sciences, 2021Haroon Khan +2 more
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