Results 31 to 40 of about 177,677 (360)

CYP-omega-hydroxylation-dependent metabolites of arachidonic acid inhibit the basolateral 10pS chloride channel in the rat thick ascending limb [PDF]

, 2009
Metabolites of arachidonic acid influence sodium chloride (NaCl) transport in the thick ascending limb. Because a 10pS Cl channel is the major type of chloride channel in the basolateral membrane of this nephron segment, we explored the effect of ...
Gu, Feng, Gu, Rui-Min, Kong, Shumin, Liu, Liping, Wang, Lijun, Wang, Mingxiao, Wang, Wen-Hui, Wu, Peng, Yang, Lei, Zhai, Yuanyuan, Zhang, Chengbiao, Zhang, Jiye, Zhang, Yunhong   +12 more
core   +1 more source

Effects of unsaturated fatty acids (Arachidonic/Oleic Acids) on stability and structural properties of Calprotectin using molecular docking and molecular dynamics simulation approach.

PLoS ONE, 2020
Calprotectin is a heterodimeric protein complex with two subunits called S100A8/A9. The protein has an essential role in inflammation process and various human diseases.
Nematollah Gheibi, Mohamad Ghorbani, Hanifeh Shariatifar, Alireza Farasat   +3 more
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Dietary arachidonic acid increases deleterious effects of amyloid-β oligomers on learning abilities and expression of AMPA receptors: putative role of the ACSL4-cPLA2 balance

Alzheimer’s Research & Therapy, 2017
Background Polyunsaturated fatty acids play a crucial role in neuronal function, and the modification of these compounds in the brain could have an impact on neurodegenerative diseases such as Alzheimer’s disease.
Mélanie H. Thomas, Cédric Paris, Mylène Magnien, Julie Colin, Sandra Pelleïeux, Florence Coste, Marie-Christine Escanyé, Thierry Pillot, Jean-Luc Olivier   +8 more
doaj   +1 more source

Interaction of solid organic acids with carbon nanotube field effect transistors [PDF]

Chem. Phys. Lett. 430 (2006) 75, 2007
A series of solid organic acids were used to p-dope carbon nanotubes. The extent of doping is shown to be dependent on the pKa value of the acids. Highly fluorinated carboxylic acids and sulfonic acids are very effective in shifting the threshold voltage and making carbon nanotube field effect transistors to be more p-type devices.
arxiv   +1 more source

Proteasome inhibitors: Their effects on arachidonic acid release from cells in culture and arachidonic acid metabolism in rat liver cells [PDF]

, 2004
BACKGROUND: I have postulated that arachidonic acid release from rat liver cells is associated with cancer chemoprevention. Since it has been reported that inhibition of proteasome activities may prevent cancer, the effects of proteasome inhibitors on ...
Levine, Lawrence
core   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Phospholipid, arachidonate and eicosanoid signaling in schizophrenia

Oilseeds and fats, crops and lipids, 2016
This paper reviews the potential role of arachidonic acid in the pathophysiology of schizophrenia. We discuss how abnormal levels of arachidonic acid may arise, and how dysregulation of signaling molecules derived from it have the potential to disrupt ...
Messamore Erik, Yao Jeffrey K.
doaj   +1 more source

FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer

Nature Communications, 2023
Colonocyte metabolism shapes the microbiome. Metabolites are the main mediators of information exchange between intestine and microbial communities. Arachidonic acid (AA) is an essential polyunsaturated fatty acid and its role in colorectal cancer (CRC ...
Chunjie Xu, Lei Gu, Lipeng Hu, Chunhui Jiang, Qing Li, Longci Sun, Hong Zhou, Ye Liu, Hanbing Xue, Jun Li, Zhigang Zhang, Xueli Zhang, Qing Xu   +12 more
doaj   +1 more source

Arachidonic Acid Production by Fungi [PDF]

Applied and Environmental Microbiology, 1991
After preliminary screening, Mortierella alpina and Mortierella elongata were compared with respect to arachidonic acid content. M. alpina ATCC 16266 produced 2.1 g of arachidonic acid per liter in media containing 10% glucose while the highest percentage of ...
Pratima Bajpai, Owen P. Ward, Pramod K. Bajpai   +2 more
openaire   +3 more sources