Results 41 to 50 of about 177,677 (360)
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
The Relationship Between Arachidonic Acid Release and Catecholamine Secretion from Cultured Bovine Adrenal Chromaffin Cells [PDF]
, 1984 Increased arachidonic acid release occurred during activation of catecholamine secretion from cul- tured bovine adrenal medullary chromaffin cells. The nicotinic agonist l,l-dimethyl-4-phenylpiperazinium (DMPP) caused an increased release of prcincubated
Frye, Roy A., Holz, Ronald W.
core +1 more source
Charting the landscape of the environmental exposome
iMeta, Volume 1, Issue 4, December 2022., 2022 We describe the biological and chemical components of the environmental exposomes in three major environmental matrices that are highly relevant to human and social‐economical health—air, soil, and water. We discuss how different exposome components can interact with each other. Finally, we propose a list of outstanding challenges to be tackled to push
Xin Wei +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.The discovery of LIBX‐A401, a potent and selective ACSL4 inhibitor derived from rosiglitazone is reported. HDX‐MS reveals that LIBX‐A401 stabilizes the ACSL4 C‐terminus and alters the fatty acid (FA) gate domain. Consistently, photoaffinity labeling, molecular dynamics, and mutagenesis identify key binding residues within the FA pocket.
Darius Mazhari Dorooee +19 more
wiley +2 more sources
Dietary arachidonic acid: a Janus face actor in brain and Alzheimer’s disease?
Oilseeds and fats, crops and lipids, 2018 Arachidonic acid is the second polyunsaturated fatty acid in brain and the first one belonging to the ω-6 series. Dietary intakes of arachidonic are between 50 and 300 mg/day in western diets but they might be underestimated. Triglycerides from fat would
Pinchaud Katleen +2 more
doaj +1 more source
Frontiers in Endocrinology, 2021 Recurrent spontaneous abortion (RSA) remains a critical and challenging problem in reproduction. To discover novel biomarkers for RSA, ultra performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) metabolomics approach was applied to ...
Meihe Li +6 more
doaj +1 more source
Journal of Applied Toxicology, Volume 43, Issue 2, Page 272-286, February 2023., 2023 Abstract This study focused on the impact in 3T3 fibroblasts of several types of empty and curcumin‐ and resveratrol‐loaded solid lipid nanoparticles (SLN) on cell viability and lipid metabolism in relation to their lipid content and encapsulated drug.
Antonella Rosa +5 more
wiley +1 more source
Symmetry Scheme for Amino Acid Codons [PDF]
Phys.Rev.E65, 021912 (2002), 2003 Group theoretical concepts are invoked in a specific model to explain how only twenty amino acids occur in nature out of a possible sixty four. The methods we use enable us to justify the occurrence of the recently discovered twenty first amino acid selenocysteine, and also enables us to predict the possible existence of two more, as yet undiscovered ...
arxiv +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19? [PDF]
arXiv, 2020 The SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19.
arxiv