Results 61 to 70 of about 177,677 (360)

Meteoritic Abundances of Fatty Acids and Potential Reaction Pathways in Planetesimals [PDF]

Icarus, 2019, 319, 685-700, 2018
The origin of fatty acids on the prebiotic Earth is important as they likely formed the encapsulating membranes of the first protocells. Carbon-rich meteorites (i.e., carbonaceous chondrites) such as Murchison and Tagish Lake are well known to contain these molecules, and their delivery to the early planet by intense early meteorite bombardments ...
arxiv   +1 more source

Hydrocortisone inhibits prostaglandin production but not arachidonic acid release from cultured macrophages [PDF]

, 1984
We have investigated the action of hydrocortisosone on arachidonic acid mobilisation in cultures of mouse peritoneal macrophages, mouse L929 cells and the mouse macrophage-like cell line RAW264.
John N. Wood, Paul R. Coote, John Rhodes, Lewis, Dvorak, Wightman, Hong, Gemsa, Rhodes, Rascke, Sanford, Salmon, Salmon, Heiman, Dray, Clancy, Hirata   +16 more
core   +5 more sources

Tumor Microenvironment Triggered In Situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor Embolization

Advanced Science, EarlyView.
Occlusion of tumor blood vessels represents a promising yet challenging approach in cancer treatment. Herein, supramolecularly engineered platelets conjugated with morphology‐transformable nanoparticles is developed for precise tumor embolization. The engineered platelets actively accumulate at tumor sites following induced blood vessel injury.
Junyan Li, Ziyi Wang, Ruifeng Luo, Xingping Quan, Hong U Fong, Qian Cheng, Jianwen Wei, Leo Wang, Yonghua Zhao, Ruibing Wang   +9 more
wiley   +1 more source

Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES‐1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor

Molecular Informatics, Volume 41, Issue 12, December 2022., 2022
Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active enzyme trimer system (Model A), namely that bound to three glutathione (GSH) cofactor ...
Simone Di Micco, Gianluigi Lauro, Giuseppe Bifulco   +2 more
wiley   +1 more source

Chronic N-methyl-d-aspartate administration increases the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat

Journal of Lipid Research, 2008
Whereas antibipolar drug administration to rats reduces brain arachidonic acid turnover, excessive N-methyl-d-aspartate (NMDA) signaling is thought to contribute to bipolar disorder symptoms and may increase arachidonic acid turnover in rat brain ...
Ho-Joo Lee, Jagadeesh S. Rao, Lisa Chang, Stanley I. Rapoport, Richard P. Bazinet   +4 more
doaj  

Tamoxifen and the Rafoxifene analog LY117018: their effects on arachidonic acid release from cells in culture and on prostaglandin I₂ production by rat liver cells

BMC Cancer, 2004
Background Tamoxifen is being used successfully to treat breast cancer. However, tamoxifen also increases the risk of developing endometrial cancer in postmenopausal women.
Levine Lawrence
doaj   +1 more source

The FADS1 rs174550 Genotype Modifies the n‐3 and n‐6 PUFA and Lipid Mediator Responses to a High Alpha‐Linolenic Acid and High Linoleic Acid Diets

Molecular Nutrition &Food Research, Volume 66, Issue 24, December 2022., 2022
This study aimed to explore the differences in the plasma fatty acid and lipid mediator concentrations in response to dietary polyunsaturated fatty acids (PUFA) between carriers of the FADS1 rs174550 TT and CC genotypes. Plasma concentrations of long‐chain PUFAs and their derived bioactive lipid mediators changed in a genotype dependent manner in ...
Topi Meuronen, Maria A. Lankinen, Johan Kolmert, Vanessa Derenji de Mello, Taisa Sallinen, Jyrki Ågren, Kirsi A. Virtanen, Markku Laakso, Craig E. Wheelock, Jussi Pihlajamäki, Ursula Schwab   +10 more
wiley   +1 more source

Metabolism of arachidonic acid-l-14C in the rat

Journal of Lipid Research, 1965
The metabolism of arachidonic acid-1-14C has been studied in the rat. The acid was fed as a component of randomly rearranged soybean oil; its absorption was greater than 96%.
Robert H. Coots
doaj  

LDL fatty acids composition as a risk biomarker of cardiovascular disease

Artery Research, 2017
Objective: Fatty acid composition of Low-density lipoprotein (LDL) particle is an effective factor in LDL oxidation and atherosclerotic plaques formation.
Hashem Nayeri, Gholam Ali Naderi, Sedigheh Asgari, Masoumeh Sadeghi, Maryam Boshtam, Samaneh Mohamadzadeh, Nasim Babaknejad   +6 more
doaj   +1 more source

Arachidonic acid as a bioactive molecule [PDF]

Journal of Clinical Investigation, 2001
Arachidonic acid is a slippery molecule that owes its mobility to its four cis double bonds. These are the source of its flexibility, keeping the pure fatty acid liquid, even at subzero temperatures, and helping to give mammalian cell membranes their correct fluidity at physiological temperatures.
openaire   +3 more sources