Results 81 to 90 of about 2,614,074 (305)

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 3021294 A1)

, 2007
The present invention relates to a new process for the production of arachidonic acid and/or eicosapentaenoic acid in plants through the co-expression of a ”-12-/”-15-desaturase, ”-9-elongase, ”-8-desaturase and a ”-5-desaturase and a process for the ...
Sayanova, O. V., Napier, J. A.
core  

Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 2621214 C) [PDF]

, 2018
Vectors and transgenic plants containing said nucleic acid ...
Sayanova, O. V., Napier, J. A.
core  

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Arachidonic Acid Stress Impacts Pneumococcal Fatty Acid Homeostasis

Frontiers in Microbiology, 2018
Free fatty acids hold dual roles during infection, serving to modulate the host immune response while also functioning directly as antimicrobials. Of particular importance are the long chain polyunsaturated fatty acids, which are not commonly found in ...
Bart A. Eijkelkamp, Stephanie L. Begg, Victoria G. Pederick, Claudia Trapetti, Melissa K. Gregory, Jonathan J. Whittall, James C. Paton, Christopher A. McDevitt   +7 more
doaj   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

The discovery and early structural studies of arachidonic acid

Journal of Lipid Research, 2016
Arachidonic acid and esterified arachidonate are ubiquitous components of every mammalian cell. This polyunsaturated fatty acid serves very important biochemical roles, including being the direct precursor of bioactive lipid mediators such as ...
Sarah A. Martin, Alan R. Brash, Robert C. Murphy   +2 more
doaj   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Stereospecificity of the products of the fatty acid oxygenases derived from psoriatic scales.

Journal of Lipid Research, 1991
The principal in vivo oxygenase products of arachidonic acid and linoleic acid in psoriatic skin scales are 12-hydroxyeicosatetraenoic acid (R/S ratio = 5.7), 13-hydroxyoctadecadienoic acid (S/R = 1.9), and 9-hydroxyoctadecadienoic acid (R/S = 2.4 ...
AN Baer, PB Costello, FA Green
doaj   +1 more source

Ankle-brachial index and eicosapentaenoic acid/arachidonic acid ratio in smokers with type 2 diabetes mellitus

, 2016
Introduction The ankle-brachial index (ABI) is an indicator of peripheral arterial damage and a low (ABI ≤ 1.0) or borderline (ABI = 1.00–1.09) value is associated with risk of cardiovascular disease events.
Shun Ishibashi, Kazuhiko Kotani, Kenta Okada   +2 more
core   +1 more source

Neuroprotection after transient middle cerebral artery occlusion in male rats using kojic acid nanostructured lipid carriers: A behavioral, biochemical, and histological study on hippocampal CA1 region

Animal Models and Experimental Medicine, EarlyView.
This study demonstrates that kojic acid–loaded nanostructured lipid carriers (KA‐NLC) provide significant neuroprotection in a male rat model of middle cerebral artery occlusion (MCAO)–induced stroke. Treatment with KA‐NLCs reduced cerebral edema, improved motor and coordination balance and neurological scores, and enhanced spatial and avoidance memory.
Mobina Gheibi, Erfan Ghadirzadeh, Javid Tebyani, Seyedeh Mohadeseh Moyaedi, Khadijeh Khezri, Majid Saeedi, Ali Siahposht‐Khachaki, Narges Karimi, Melika Pourhossein, Shiva Shadi, Sasan Shafiei, Atena Sharifi‐Razavi   +11 more
wiley   +1 more source