Results 101 to 110 of about 122,999 (308)

Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation

Cell Reports, 2017
The G protein-coupled receptor Smoothened (Smo) is the signal transducer of the Sonic Hedgehog (Shh) pathway. Smo signals through G protein-dependent and -independent routes, with G protein-independent canonical signaling to Gli effectors requiring Smo ...
Angela M. Arensdorf, Miriam E. Dillard, Jacob M. Menke, Matthew W. Frank, Charles O. Rock, Stacey K. Ogden   +5 more
doaj   +1 more source

Arachidonic acid and colorectal adenoma risk: a Mendelian randomization study

, 2018
Chelsea A Isom,1 Martha J Shrubsole,2,3 Qiuyin Cai,2 Walter E Smalley,4,5 Reid M Ness,5 Wei Zheng,2,3 Harvey J Murff3,6 1Department of General Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; 2Division of Epidemiology, Vanderbilt ...
Murff HJ, Cai Q, Isom CA, Shrubsole MJ, Smalley WE, Ness RM, Zheng W   +6 more
core  

The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. [PDF]

, 2008
This paper reviews current knowledge on the role of the long-chain polyunsaturated fatty acids (LC-PUFA), docosahexaenoic acid (DHA, C22:6n-3) and arachidonic acid (AA, 20:4n-6), in maternal and term infant nutrition as well as infant development ...
Alexandre Lapillonne, Tamas Decsi, S. Forsyth, Niels J Secher, Berthold Koletzko, Willatts, Peter, MD Berthold Koletzko, C. Agostoni, Hansjosef Bö Hles, N. J. Secher, NN, NN, Szajewska, Hania, Lapillonne, Alexandre, Irene Cetin, Carlo Agostoni, Ricardo Uauy, Putet, Guy, Eric Lien, Forsyth, Stewart, I. Hoesli, Uauy, Ricardo, Mike Symonds, Dudenhausen, Joachim W, Uauy Dagach-Imbarack, Ricardo, Cristina Campoy, W. Holzgreve, Stewart Forsyth, Hania Szajewska, T. Decsi, Irene Hoesli, Koletzko, Berthold, Lien, Eric, J. W. Dudenhausen, Peter Willatts, Secher, Niels J, C. Campoy, Guy Putet, B. Koletzko, H. Szajewska, E. Lien, G. Putet, Joachim W Dudenhausen, Dudenhausen, Joachim W., Boehles, Hansjosef, Hoesli, Irene, Böhles, Hansjosef, Decsi, Tamas, Dupont, Cristophe, Cristophe Dupont, M. Symonds, Campoy, Cristina, Secher, Niels J., Symonds, Mike, P. Willatts, Cetin, Irene, A. Lapillonne, I. Cetin, Agostoni, Carlo, H. Böhles, Wolfgang Holzgreve, Holzgreve, Wolfgang, R. Uauy, World Association of Perinatal Medicine Dietary Guidelines Worki, C. Dupont   +63 more
core   +1 more source

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source

Metabolomic analysis reveals the role of gut microbiota metabolic disorders in heart failure due to congenital heart disease

Scientific Reports
This study aimed to explore the effects of gut microbiota metabolic disorders caused by gut microbiota dysbiosis on heart failure due to congenital heart disease (CHD) through metabolomic analysis. Patients with congestive heart failure caused by left-to-
Qi-Liang Zhang, Qiong-Xia Ou, Yi Wang, Yi-Nan Liu, Ya-Ting Zeng, Qiang Chen, Zeng-Chun Wang   +6 more
doaj   +1 more source

Platelet and Brain Fatty acid transfer: Hypothesis on Arachidovic Acid and its relationship to Major Depression

Journal of Biological Research, 2009
Depression may be linked to changes of the fatty acid profile in many biological districts such as platelets, plasma phospholipids, rat brain and red blood cells. The platelet is one of the most extensively researched biological markers in psychiatry. In
M. Cocchi, P. Amato, A De Lucia
doaj   +1 more source

Plasma Exosome Metabolomics Reveal Stage‐Specific Alterations in Elderly Women With Premetabolic and Metabolic Syndrome

Chronic Diseases and Translational Medicine, EarlyView.
Shared differential metabolites identified across the three sample groups. (A) Venn diagram of differential metabolites between the two comparison groups; Based on the detected levels of these overlapping differential metabolites, (B) d‐Arabitol, (C) Triclosan, (D) Iloprost, (E) Tetracosanoic acid, and (F) Omeprazole sulfone. Box plots were constructed
Mengtao Qian, Dan Nie, Qianyi Gao, Xingbo Mo, Huan Zhang   +4 more
wiley   +1 more source

17β Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats

International Journal of Endocrinology, 2015
Prevalence of metabolic syndrome and progression of nephropathy depend on sex. We examined a protective effect of estradiol against nephropathy in metabolic syndrome through the modulation of the arachidonic acid metabolism by activating the 5 ...
A. M. Zúñiga-Muñoz, V. Guarner Lans, E. Soria-Castro, E. Diaz-Diaz, R. Torrico-Lavayen, E. Tena-Betancourt, I. Pérez-Torres   +6 more
doaj   +1 more source

Eicosapentaenoic acid and prostacyclin production by cultured human endothelial cells.

Journal of Lipid Research, 1983
Human umbilical vein endothelial cells incorporate eicosapentaenoic acid (EPA) when this fatty acid is present in the culture medium. From 30 to 70% of the uptake remains as EPA, and much of the remainder is elongated to docosapentaenoic acid. All of the
A A Spector, T L Kaduce, P H Figard, K C Norton, J C Hoak, R L Czervionke   +5 more
doaj   +1 more source

arachidonic acid metabolism-png

, 2014
unigenes mapped to arachidonic acid ...
Karen Fugate (480954)
core   +1 more source