Results 71 to 80 of about 183,297 (300)

Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo. [PDF]

, 2013
In this study, we characterized early biochemical changes associated with sertraline and placebo administration and changes associated with a reduction in depressive symptoms in patients with major depressive disorder (MDD).
Bogdanov, MB, Boyle, SH, Churchill, E, Delnomdedieu, M, Fiehn, O, Kaddurah-Daouk, R, Krishnan, RR, Pickering, E, Rush, AJ, Wang, Z, Wikoff, WR, Zhu, H   +11 more
core   +2 more sources

The Emerging Parkinson's Disease Oxylipin‐Ome

Advanced Science, EarlyView.
ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley   +1 more source

LDL fatty acids composition as a risk biomarker of cardiovascular disease

Artery Research, 2017
Objective: Fatty acid composition of Low-density lipoprotein (LDL) particle is an effective factor in LDL oxidation and atherosclerotic plaques formation.
Hashem Nayeri, Gholam Ali Naderi, Sedigheh Asgari, Masoumeh Sadeghi, Maryam Boshtam, Samaneh Mohamadzadeh, Nasim Babaknejad   +6 more
doaj   +1 more source

Arachidonic Acid Production by Fungi [PDF]

Applied and Environmental Microbiology, 1991
After preliminary screening, Mortierella alpina and Mortierella elongata were compared with respect to arachidonic acid content. M. alpina ATCC 16266 produced 2.1 g of arachidonic acid per liter in media containing 10% glucose while the highest percentage of ...
P K, Bajpai, P, Bajpai, O P, Ward
openaire   +2 more sources

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Level of Arachidonic Acid and State of Peroxidation Processes in Patients with Aspirin-Intolerant Polypous Rhinosinusitis

Galician Medical Journal, 2016
The main peculiarity of aspirin-intolerant polypous rhinosinusitis pathogenesis is the presence of “genetic block” of constitutive cyclooxygenase being the key enzyme of the arachidonic acid metabolism.
Ivanna Koshel
doaj   +1 more source

Mesopelagic Fish as a Promising New Source of Omega‐3 Fatty Acids in Comparison With Australian Commercial Seafood

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Global dietary guidelines consistently recommend regular seafood consumption to support adequate omega‐3 long‐chain (≥ C20) polyunsaturated fatty acid (n‐3 LC‐PUFA) intake. Most international health authorities advise two servings of seafood per week, including at least one serve of oily fish, to achieve approximately 500 mg/day of combined ...
Bowen Zhang, Patti Virtue, Peter D. Nichols, Kim Jye Lee Chang   +3 more
wiley   +1 more source

Conversion of eicosapentaenoic acid to chain-shortened omega–3 fatty acid metabolites by peroxisomal oxidation1

Journal of Lipid Research, 1998
Human skin fibroblasts can convert arachidonic acid to 14- and 16-carbon polyunsaturated fatty acid products by peroxisomal β-oxidation. The purpose of this study was to determine whether similar products are formed from eicosapentaenoic acid (EPA) and ...
Deborah E. Williard, Terry L. Kaduce, Shawn D. Harmon, Arthur A. Spector   +3 more
doaj   +1 more source

Algal polyunsaturated fatty acids and effects on plankton ecology and other organisms [PDF]

, 2004
A review and discussion of the effects of algal polyunsaturated fatty acids (PUFAs) on phytoplankton and zooplankton ecology and their effects on other animal systems.
Ikawa, Miyoshi
core   +1 more source