Results 41 to 50 of about 124,415 (361)

Basal and inducible anti-inflammatory epoxygenase activity in endothelial cells [PDF]

, 2014
The roles of CYP lipid-metabolizing pathways in endothelial cells are poorly understood. Human endothelial cells expressed CYP2J2 and soluble epoxide hydrolase (sEH) mRNA and protein.
Ara A. Askari, Askari, Baum, Bishop-Bailey, Bouis, Bystrom, Bystrom, Campbell, Capdevila, Darryl C. Zeldin, David Bishop-Bailey, Deng, Falck, Fang, Fred B. Lih, Hercule, Hwang, Imig, Jung, Lauterbach, Lee, Loppnow, Luo, Matthew L. Edin, Morisseau, Piqueras, Piqueras, Revermann, Schuchardt, Scott Thomson, Spiecker, Vinay, Zeldin, Zeldin, Zeldin, Zhang   +35 more
core   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Plasma oxylipins and unesterified precursor fatty acids are altered by DHA supplementation in pregnancy: Can they help predict risk of preterm birth? [PDF]

, 2019
Oxidized lipids derived from omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids, collectively known as oxylipins, are bioactive signaling molecules that play diverse roles in human health and disease.
Best, Karen, Gibson, Robert A, Horowitz, Mark S, Jensen, Jennifer, Makrides, Maria, Ramsden, Christopher E, Taha, Ameer Y, Yelland, Lisa N, Yuan, Zhi-Xin, Zamora, Daisy   +9 more
core   +2 more sources

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Inhibition of the Nicotinic Ion Channel by Arachidonic Acid and Other Unsaturated Fatty, Acids in Chromaffin Cells from Bovine Adrenal Medulla

CHIMIA, 1991
The effects of arachidonic and other cis-unsaturated fatty acids were investigated in cultured chromaffin cells from bovine adrenal medulla with respect to Ca2+ influx and secretion of catecholamines.
Markus U. Ehrengruber, Peter Zahler
doaj   +2 more sources

Novel liquid chromatography–mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos

Redox Biology, 2014
To test the hypothesis that embryogenesis depends upon α-tocopherol (E) to protect embryo polyunsaturated fatty acids (PUFAs) from lipid peroxidation, new methodologies were applied to measure α-tocopherol and fatty acids in extracts from saponified ...
Katie M. Lebold, Jay S. Kirkwood, Alan W. Taylor, Jaewoo Choi, Carrie L. Barton, Galen W. Miller, Jane La Du, Donald B. Jump, Jan Frederik Stevens, Robert L. Tanguay, Maret G. Traber   +10 more
doaj   +1 more source

Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19? [PDF]

arXiv, 2020
The SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19.
arxiv  

Gut Microbiota-derived Bile Acids Promote Gamma-secretase Activity Through Interactions with Nicastrin Subunits [PDF]

arXiv, 2023
Alzheimer's disease (AD) has emerged as a progressively pervasive neurodegenerative disorder worldwide. Bile acids, synthesized in the liver and modified by the gut microbiota, play pivotal roles in diverse physiological processes, and their dysregulation in individuals with AD has been well-documented.
arxiv  

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

LC‐MS and High‐Throughput Data Processing Solutions for Lipid Metabolic Tracing Using Bioorthogonal Click Chemistry

Angewandte Chemie, EarlyView.
This study introduces an integrated analytical and bioinformatics platform for high‐throughput tracing of lipid metabolism using bioorthogonal alkyne fatty acids and optimized LC‐MS workflow. Applied to human fibrosarcoma cells, the method traced fatty acid metabolism, revealing nuances in sphingolipid routing and metabolic bottlenecks, highlighting ...
Palina Nepachalovich, Stefano Bonciarelli, Gabriele Lombardi Bendoula, Jenny Desantis, Michela Eleuteri, Christoph Thiele, Laura Goracci, Maria Fedorova   +7 more
wiley   +2 more sources