Results 61 to 70 of about 5,117,744 (378)

Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs

open access: yesAdvanced Healthcare Materials, EarlyView.
This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani   +4 more
wiley   +1 more source

Temperature and time-dependent effects of delayed blood processing on oxylipin concentrations in human plasma. [PDF]

open access: yes, 2019
BACKGROUND:Oxidized derivatives of polyunsaturated fatty acids, collectively known as oxylipins, are labile bioactive mediators with diverse roles in human physiology and pathology.
Gibson, Robert A   +8 more
core   +1 more source

Arachidonic Acid-metabolizing Cytochrome P450 Enzymes Are Targets of ω-3 Fatty Acids*

open access: yesJournal of Biological Chemistry, 2010
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) protect against cardiovascular disease by largely unknown mechanisms. We tested the hypothesis that EPA and DHA may compete with arachidonic acid (AA) for the conversion by cytochrome P450 (CYP ...
Cosima Arnold   +11 more
semanticscholar   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

open access: yesAdvanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han   +9 more
wiley   +1 more source

Metabolism of n-3 polyunsaturated fatty acids and modification of phospholipids in cultured rabbit aortic smooth muscle cells.

open access: yesJournal of Lipid Research, 1985
The metabolism of the linolenic acid family (n-3) of fatty acids, e.g., linolenic, eicosapentaenoic, and docosahexaenoic acids, in cultured smooth muscle cells from rabbit aorta was compared to the metabolism of linoleic and arachidonic acids.
N Morisaki   +7 more
doaj  

Plasmalogens in Innate Immune Cells: From Arachidonate Signaling to Ferroptosis

open access: yesBiomolecules
Polyunsaturated fatty acids such as arachidonic acid are indispensable components of innate immune signaling. Plasmalogens are glycerophospholipids with a vinyl ether bond in the sn-1 position of the glycerol backbone instead of the more common sn-1 ...
Jesús Balsinde, María A. Balboa
doaj   +1 more source

Production of eicosapentaenoic and arachidonic acids by an antarctic bacterium: response to growth temperature

open access: yes, 1997
A psychrophilic bacterium, designated strain 651, was isolated from Antarctic sea ice collected from Prydz Bay, Eastern Antarctica. The fatty acid composition of the strain was characteristic of the Flavobacterium-Cytophaga-Microscillia group.
D. Nichols   +3 more
semanticscholar   +1 more source

Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

open access: yesBritish Journal of Clinical Pharmacology, 2013
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are n-3 fatty acids found in oily fish and fish oil supplements. These fatty acids are able to inhibit partly a number of aspects of inflammation including leucocyte chemotaxis, adhesion molecule
P. Calder
semanticscholar   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

open access: yesAdvanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang   +10 more
wiley   +1 more source

Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles

open access: yesJournal of Lipid Research, 1973
A comparative study was made on the fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in various subcellular fractions of liver and testis from rats of different ages.
Sixta Ayala   +4 more
doaj  

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