Sulfated lactosyl archaeol (SLA) archaeosomes as a vaccine adjuvant [PDF]
Human Vaccines & ImmunotherapeuticsArchaeosomes are liposomes traditionally comprised of total polar lipids or semi-synthetic glycerolipids of ether-linked isoprenoid phytanyl cores with varied glycol- and amino-head groups. We have developed a semi-synthetic archaeosome formulation based
Bassel Akache, Michael J. McCluskie
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Safety and biodistribution of sulfated archaeal glycolipid archaeosomes as vaccine adjuvants [PDF]
Human Vaccines & Immunotherapeutics, 2018 Archaeosomes are liposomes comprised of ether lipids derived from various archaea. Unlike conventional ester-linked liposomes, archaeosomes exhibit high pH and thermal stability. As adjuvants, archaeosomes can induce robust, long-lasting humoral and cell-
Bassel Akache +6 more
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TLR Agonist Augments Prophylactic Potential of Acid Inducible Antigen Rv3203 against Mycobacterium tuberculosis H37Rv in Experimental Animals. [PDF]
PLoS ONE, 2016 In general, the members of Lip gene family of Mycobacterium tuberculosis evoke strong immune response in the host. Keeping this fact into consideration, we investigated role of Rv3203, a cell wall associated protein with lipolytic activity, in imparting ...
Owais Mohammad +9 more
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Sulfated archaeol glycolipids: Comparison with other immunological adjuvants in mice. [PDF]
PLoS ONE, 2018 Archaeosomes are liposomes traditionally comprised of total polar lipids (TPL) or semi-synthetic glycerolipids of ether-linked isoprenoid phytanyl cores with varied glyco- and amino-head groups.
Bassel Akache +10 more
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Archaeosome Adjuvant Overcomes Tolerance to Tumor-Associated Melanoma Antigens Inducing Protective CD8+ T Cell Responses [PDF]
Clinical and Developmental Immunology, 2010 Vesicles comprised of the ether glycerolipids of the archaeon Methanobrevibacter smithii (archaeosomes) are potent adjuvants for evoking CD8+ T cell responses.
Lakshmi Krishnan +4 more
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Ether lipid vesicle-based antigens impart protection against experimental listeriosis [PDF]
International Journal of Nanomedicine, 2012 Mairaj Ahmed Ansari,1 Swaleha Zubair,2 Saba Tufail,1 Ejaj Ahmad,1 Mohsin Raza Khan,1 Zainuddin Quadri,1 Mohammad Owais,11Interdisciplinary Biotechnology Unit, 2Women's College, Aligarh Muslim University, Aligarh, UP, IndiaBackground: Incidence of
Ansari MA +6 more
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Sulfated archaeal glycolipid archaeosomes as a safe and effective vaccine adjuvant for induction of cell-mediated immunity [PDF]
Human Vaccines & Immunotherapeutics, 2017 Archaeosomes are liposomal vesicles composed of ether glycerolipids unique to the domain of Archaea. Unlike conventional ester-linked liposomes, archaeosomes exhibit high stability and possess strong adjuvant and immunostimulatory properties making them ...
Michael J. McCluskie +2 more
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Effect of Different Adjuvants on the Longevity and Strength of Humoral and Cellular Immune Responses to the HCV Envelope Glycoproteins [PDF]
Vaccines, 2019 Infection by Hepatitis C virus (HCV) can lead to liver cirrhosis/hepatocellular carcinoma and remains a major cause of serious disease morbidity and mortality worldwide.
Bassel Akache +2 more
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Archaeosome Immunostimulatory Vaccine Delivery System
Current Drug Delivery, 2005 Archaeosomes are liposomes made from the polar ether lipids of Archaea. These lipids are unique and distinct in structure from the ester lipids found in Eukarya and Bacteria. The regularly branched and usually fully saturated isopranoid chains of archaeal polar lipids are attached via ether bonds to the sn-2,3 carbons of the glycerol backbone(s).
Patel, Girishchandra B., Chen, Wangxue
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RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis. [PDF]
PLoS ONE, 2011 BackgroundThe absence of certain genomic loci that are present in most of the virulent strains of Mycobacterium tuberculosis as well as lack of lasting memory responses are some of the major causes attributed to the non effectiveness of Bacille Calmette ...
Mairaj Ahmed Ansari +7 more
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