Sulfated lactosyl archaeol (SLA) archaeosomes as a vaccine adjuvant [PDF]
Human Vaccines & ImmunotherapeuticsArchaeosomes are liposomes traditionally comprised of total polar lipids or semi-synthetic glycerolipids of ether-linked isoprenoid phytanyl cores with varied glycol- and amino-head groups. We have developed a semi-synthetic archaeosome formulation based
Bassel Akache, Michael J. McCluskie
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Safety and biodistribution of sulfated archaeal glycolipid archaeosomes as vaccine adjuvants [PDF]
Human Vaccines & Immunotherapeutics, 2018 Archaeosomes are liposomes comprised of ether lipids derived from various archaea. Unlike conventional ester-linked liposomes, archaeosomes exhibit high pH and thermal stability. As adjuvants, archaeosomes can induce robust, long-lasting humoral and cell-
Bassel Akache +6 more
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TLR Agonist Augments Prophylactic Potential of Acid Inducible Antigen Rv3203 against Mycobacterium tuberculosis H37Rv in Experimental Animals. [PDF]
PLoS ONE, 2016 In general, the members of Lip gene family of Mycobacterium tuberculosis evoke strong immune response in the host. Keeping this fact into consideration, we investigated role of Rv3203, a cell wall associated protein with lipolytic activity, in imparting ...
Owais Mohammad +9 more
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Sulfated archaeol glycolipids: Comparison with other immunological adjuvants in mice. [PDF]
PLoS ONE, 2018 Archaeosomes are liposomes traditionally comprised of total polar lipids (TPL) or semi-synthetic glycerolipids of ether-linked isoprenoid phytanyl cores with varied glyco- and amino-head groups.
Bassel Akache +10 more
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Ether lipid vesicle-based antigens impart protection against experimental listeriosis [PDF]
International Journal of Nanomedicine, 2012 Mairaj Ahmed Ansari,1 Swaleha Zubair,2 Saba Tufail,1 Ejaj Ahmad,1 Mohsin Raza Khan,1 Zainuddin Quadri,1 Mohammad Owais,11Interdisciplinary Biotechnology Unit, 2Women's College, Aligarh Muslim University, Aligarh, UP, IndiaBackground: Incidence of
Ansari MA +6 more
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Sulfated archaeal glycolipid archaeosomes as a safe and effective vaccine adjuvant for induction of cell-mediated immunity [PDF]
Human Vaccines & Immunotherapeutics, 2017 Archaeosomes are liposomal vesicles composed of ether glycerolipids unique to the domain of Archaea. Unlike conventional ester-linked liposomes, archaeosomes exhibit high stability and possess strong adjuvant and immunostimulatory properties making them ...
Michael J. McCluskie +2 more
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Synthetic Archaeosome Vaccines Containing Triglycosylarchaeols Can Provide Additive and Long-Lasting Immune Responses That Are Enhanced by Archaetidylserine [PDF]
Archaea, 2012 The relation between archaeal lipid structures and their activity as adjuvants may be defined and explored by synthesizing novel head groups covalently linked to archaeol (2,3-diphytanyl-sn-glycerol).
Dennis Whitfield, G Dennis Sprott
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The Potent in Vitro Skin Permeation of Archaeosome Made From Lipids Extracted of Sulfolobus acidocaldarius [PDF]
Archaea, 2013 Archaeosomes are a new generation of liposomes that exhibit higher stabilities under different conditions, such as high temperatures, alkaline or acidic pH, and presence of bile salts in comparison with liposomes, and can be used in biotechnology including drug, gene, and vaccine delivery.
Somayeh Handali +2 more
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The potential of archaeosomes as carriers of pDNA into mammalian cells
Artificial Cells, Nanomedicine, and Biotechnology, 2015 This paper describes the formulation of archaeosomes and the evaluation of their abilities to facilitate in vitro DNA delivery. Lipids of the H.hispanica 2TK2 strain were used in archaeosome formation, which is formulated by mixing H.hispanica 2TK2 lipids with plasmid DNA encoding green fluorescent protein (GFP) or β-galactosidase (β-gal).
Turan, Kadir +3 more
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Immunogenicity of Sulfated Lactosyl Archaeol Archaeosome-Adjuvanted Versus Non-Adjuvanted SARS-CoV-2 Spike Booster Vaccines in Young and Aged Balb/c Mice [PDF]
VaccinesBackground/Objectives: The rise of immune escape variants of the SARS-CoV-2 virus has prompted the development of vaccines based on the variant’s spike antigen sequence.
Felicity C. Stark +11 more
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