Results 31 to 40 of about 269 (141)
Chemical Biology & Drug Design, 2017 The ability of Archaea to adapt their membrane lipid compositions to extreme environments has brought in archaeosomes into consideration for the development of drug delivery systems overcoming the physical, biological blockades that the body exhibits against drug therapies.
Azade Attar +7 more
openaire +5 more sources
Simplified Admix Archaeal Glycolipid Adjuvanted Vaccine and Checkpoint Inhibitor Therapy Combination Enhances Protection from Murine Melanoma. [PDF]
Biomedicines, 2019 Archaeosomes are liposomes composed of natural or synthetic archaeal lipids that when used as adjuvants induce strong long-lasting humoral and cell-mediated immune responses against entrapped antigens.
Stark FC +10 more
europepmc +2 more sources
A Spotlight on Archaea in Humans, Livestock and Poultry: A Review. [PDF]
Vet Med SciThe microbiota includes prokaryotes (archaea and bacteria) and eukaryotes. Archaea are single‐celled prokaryotes and essential part of gut microbiome. Researches on archaea in ruminants and humans are more than mono‐gastric. The low abundance of archaea in the gut depends on the method used (metagenomics or meta‐transcriptomic) and age of people or ...
Salahi A, Abd El-Ghany WA.
europepmc +2 more sources
Synthetic archaeosome vaccines containing triglycosylarchaeols can provide additive and long-lasting immune responses that are enhanced by archaetidylserine. [PDF]
Archaea, 2012 The relation between archaeal lipid structures and their activity as adjuvants may be defined and explored by synthesizing novel head groups covalently linked to archaeol (2,3-diphytanyl-sn-glycerol).
Sprott GD +4 more
europepmc +2 more sources
The potent in vitro skin permeation of archaeosome made from lipids extracted of Sulfolobus acidocaldarius. [PDF]
Archaea, 2013 Archaeosomes are a new generation of liposomes that exhibit higher stabilities under different conditions, such as high temperatures, alkaline or acidic pH, and presence of bile salts in comparison with liposomes, and can be used in biotechnology including drug, gene, and vaccine delivery.
Moghimipour E +3 more
europepmc +2 more sources
ChemistryOpen, Volume 10, Issue 9, Page 889-895, September 2021., 2021 The isolation and structure elucidation of a tetraether lipid (TEL) fragment GDNT‐β‐Glu occurring in Sulfolobus strains are described. The investigations reveal new knowledge regarding the binding relationships which is also important for the general structure determination of intact TEL.
Alexander Scholte +7 more
wiley +1 more source
WIREs Nanomedicine and Nanobiotechnology, Volume 13, Issue 5, September/October 2021., 2021 Recent progresses in nanoparticle‐based delivery systems show potential foreground for enhancing clinical benefits while minimizing systemic toxicities in cervical cancer. Abstract Cervical cancer is a leading cause of gynecological tumor related deaths worldwide.
Peijie Zhou +3 more
wiley +1 more source
Targeted Nanotherapeutics for Respiratory Diseases: Cancer, Fibrosis, and Coronavirus
Advanced Therapeutics, Volume 4, Issue 2, February 2021., 2021 Targeted delivery of nanotherapeutics specifically to diseased lungs, pulmonary cells, and/or specific organelles offers distinct advantages over systemic delivery by enhancing efficacy of the treatment and limiting severe adverse side effects. Nanoscale based systems can transport various types of payload, simultaneously carry out several distinct ...
Joydeb Majumder, Tamara Minko
wiley +1 more source
Archaeosomes facilitate storage and oral delivery of cannabidiol
International Journal of Pharmaceutics, 2023 Cannabidiol (CBD) has received great scientific interest due to its numerous therapeutic applications. Degradation in the gastrointestinal (GI) tract, first-pass metabolism, and low water solubility restrain bioavailability of CBD to only 6% in current oral administration. Lipid-based nanocarriers are delivery systems that may enhance accessibility and
Viktor Sedlmayr +4 more
openaire +2 more sources