Results 31 to 40 of about 293 (137)

Simplified Admix Archaeal Glycolipid Adjuvanted Vaccine and Checkpoint Inhibitor Therapy Combination Enhances Protection from Murine Melanoma. [PDF]

Biomedicines, 2019
Archaeosomes are liposomes composed of natural or synthetic archaeal lipids that when used as adjuvants induce strong long-lasting humoral and cell-mediated immune responses against entrapped antigens.
Stark FC, Agbayani G, Sandhu JK, Akache B, McPherson C, Deschatelets L, Dudani R, Hewitt M, Jia Y, Krishnan L, McCluskie MJ.   +10 more
europepmc   +2 more sources

A Spotlight on Archaea in Humans, Livestock and Poultry: A Review. [PDF]

Vet Med Sci
The microbiota includes prokaryotes (archaea and bacteria) and eukaryotes. Archaea are single‐celled prokaryotes and essential part of gut microbiome. Researches on archaea in ruminants and humans are more than mono‐gastric. The low abundance of archaea in the gut depends on the method used (metagenomics or meta‐transcriptomic) and age of people or ...
Salahi A, Abd El-Ghany WA.
europepmc   +2 more sources

Effect of Different Adjuvants on the Longevity and Strength of Humoral and Cellular Immune Responses to the HCV Envelope Glycoproteins. [PDF]

Vaccines (Basel), 2019
Infection by Hepatitis C virus (HCV) can lead to liver cirrhosis/hepatocellular carcinoma and remains a major cause of serious disease morbidity and mortality worldwide.
Akache B, Deschatelets L, Harrison BA, Dudani R, Stark FC, Jia Y, Landi A, Law JLM, Logan M, Hockman D, Kundu J, Tyrrell DL, Krishnan L, Houghton M, McCluskie MJ.   +14 more
europepmc   +2 more sources

First Isolation and Structure Elucidation of GDNT‐β‐Glu – Tetraether Lipid Fragment from Archaeal Sulfolobus Strains

ChemistryOpen, Volume 10, Issue 9, Page 889-895, September 2021., 2021
The isolation and structure elucidation of a tetraether lipid (TEL) fragment GDNT‐β‐Glu occurring in Sulfolobus strains are described. The investigations reveal new knowledge regarding the binding relationships which is also important for the general structure determination of intact TEL.
Alexander Scholte, Christoph Hübner, Dieter Ströhl, Olaf Scheufler, Steffen Czich, Julia M. Börke, Gerhard Hildebrand, Klaus Liefeith   +7 more
wiley   +1 more source

Nanoparticle‐based applications for cervical cancer treatment in drug delivery, gene editing, and therapeutic cancer vaccines

WIREs Nanomedicine and Nanobiotechnology, Volume 13, Issue 5, September/October 2021., 2021
Recent progresses in nanoparticle‐based delivery systems show potential foreground for enhancing clinical benefits while minimizing systemic toxicities in cervical cancer. Abstract Cervical cancer is a leading cause of gynecological tumor related deaths worldwide.
Peijie Zhou, Wei Liu, Yong Cheng, Dong Qian   +3 more
wiley   +1 more source

Targeted Nanotherapeutics for Respiratory Diseases: Cancer, Fibrosis, and Coronavirus

Advanced Therapeutics, Volume 4, Issue 2, February 2021., 2021
Targeted delivery of nanotherapeutics specifically to diseased lungs, pulmonary cells, and/or specific organelles offers distinct advantages over systemic delivery by enhancing efficacy of the treatment and limiting severe adverse side effects. Nanoscale based systems can transport various types of payload, simultaneously carry out several distinct ...
Joydeb Majumder, Tamara Minko
wiley   +1 more source

Archaeosomes facilitate storage and oral delivery of cannabidiol

International Journal of Pharmaceutics, 2023
Cannabidiol (CBD) has received great scientific interest due to its numerous therapeutic applications. Degradation in the gastrointestinal (GI) tract, first-pass metabolism, and low water solubility restrain bioavailability of CBD to only 6% in current oral administration. Lipid-based nanocarriers are delivery systems that may enhance accessibility and
Viktor Sedlmayr, Christina Horn, David Johannes Wurm, Oliver Spadiut, Julian Quehenberger   +4 more
openaire   +2 more sources

Ultradeformable archaeosomes as new topical adjuvants

Nanomedicine: Nanotechnology, Biology and Medicine, 2012
Ultradeformable archaeosomes (UDA) are vesicles made of soybean phosphatidylcholine (SPC), sodium cholate (NaChol) and polar lipids from Halorubrum tebenquichense (3:1:3 wt/wt). Although ultradeformable liposomes (UDL, made of SPC and NaChol at 6:1 wt/wt) and UDA were neither captured nor caused cytotoxicity on keratinocytes, UDA was avidly captured by
Higa, Leticia Herminia, Schilrreff, Priscila, Perez, Ana Paula, Iriarte, Maiara A., Roncaglia, Diana Inés, Morilla, María José, Romero, Eder Lilia   +6 more
openaire   +6 more sources

Delivery systems for natural antioxidant compounds: Archaeosomes and archaeosomal hydrogels characterization and release study

International Journal of Pharmaceutics, 2011
The aim of this study was to use archaeosomes, a novel kind of liposomes made up by archaeal polar lipids, both multilamellars (MLVs) and unilamellars (SUVs), as a topical delivery system for natural antioxidant compounds recovered from olive mill waste. For comparative purpose an analogue formulation of phosphatidylcholine liposomes was prepared. SUVs
Ana, González-Paredes, Beatriz, Clarés-Naveros, María Adolfina, Ruiz-Martínez, Juan José, Durbán-Fornieles, Alberto, Ramos-Cormenzana, Mercedes, Monteoliva-Sánchez   +5 more
openaire   +3 more sources

Life under Extreme Conditions: Aeropyrum pernix and Pernisine

, 2020
eFood, Volume 1, Issue 2, Page 196-198, April 2020.
Nataša Poklar Ulrih
wiley   +1 more source