Results 51 to 60 of about 293 (137)

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
wiley   +1 more source

Nanoparticle‐Based Drug Delivery for Therapy of Lung Cancer: Progress and Challenges

Journal of Nanomaterials, Volume 2013, Issue 1, 2013., 2013
The last decade has witnessed enormous advances in the development and application of nanotechnology in cancer detection, diagnosis, and therapy culminating in the development of the nascent field of “cancer nanomedicine.” A nanoparticle as per the National Institutes of Health (NIH) guidelines is any material that is used in the formulation of a drug ...
Anish Babu, Amanda K. Templeton, Anupama Munshi, Rajagopal Ramesh, Haifeng Chen   +4 more
wiley   +1 more source

Intranasal administration of unadjuvanted SARS‐CoV‐2 spike antigen boosts antigen‐specific immune responses induced by parenteral protein subunit vaccine prime in mice and hamsters

European Journal of Immunology, Volume 54, Issue 6, June 2024.
Intranasal administration of spike protein antigen alone following an intramuscular prime with spike protein antigen adjuvanted with sulfated lactosylarchaeol (SLA) archaeosomes boosts systemic and mucosal immune responses, leading to protection from SARS‐CoV‐2 infection.
Gerard Agbayani, Bassel Akache, Tyler M. Renner, Anh Tran, Matthew Stuible, Renu Dudani, Blair A. Harrison, Diana Duque, Jegarubee Bavananthasivam, Lise Deschatelets, Usha D. Hemraz, Sophie Régnier, Yves Durocher, Michael J. McCluskie   +13 more
wiley   +1 more source

On Physical Properties of Tetraether Lipid Membranes: Effects of Cyclopentane Rings

Archaea, Volume 2012, Issue 1, 2012., 2012
This paper reviews the recent findings related to the physical properties of tetraether lipid membranes, with special attention to the effects of the number, position, and configuration of cyclopentane rings on membrane properties. We discuss the findings obtained from liposomes and monolayers, composed of naturally occurring archaeal tetraether lipids
Parkson Lee-Gau Chong, Umme Ayesa, Varsha Prakash Daswani, Ellah Chay Hur, Yosuke Koga   +4 more
wiley   +1 more source

Archaeosomes: an excellent carrier for drug and cell delivery

Drug Delivery, 2015
Archaeosomes as liposomes made with one or more ether lipids that are unique to the domain of Archaeobacteria, found in Archaea constitute a novel family of liposome. Achaean-type lipids consist of archaeol (diether) and/or caldarchaeol (tetraether) core structures.
Gurmeet, Kaur, Tarun, Garg, Goutam, Rath, Amit K, Goyal   +3 more
openaire   +2 more sources

Archaeosomes display immunoadjuvant potential for a vaccine against Chagas disease [PDF]

Human Vaccines & Immunotherapeutics, 2013
Archaeosomes (ARC), vesicles made from lipids extracted from Archaea, display strong adjuvant properties. In this study, we evaluated the ability of the highly stable ARC formulated from total polar lipids of a new Halorubrum tebenquichense strain found in Argentinean Patagonia, to act as adjuvant for soluble parasite antigens in developing ...
Higa, Leticia Herminia, Corral, Ricardo Santiago, Morilla, María José, Romero, Eder Lilia, Petray, Patricia Beatriz   +4 more
openaire   +3 more sources

Tetraether archaeal lipids promote long‐term survival in extreme conditions

Molecular Microbiology, Volume 121, Issue 5, Page 882-894, May 2024.
Unique archaeal lipid membrane composition, including membrane‐spanning, tetraether lipids, presumably contribute to survival in extreme pH, temperature, and salinity. The biosynthesis of tetraether lipids in the model species Thermococcus kodakarensis promotes survival at high temperatures, and we demonstrate that alternative lipid species are ...
Geraldy Lie Stefanus Liman, Andy A. Garcia, Kristin A. Fluke, Hayden R. Anderson, Sarah C. Davidson, Paula V. Welander, Thomas J. Santangelo   +6 more
wiley   +1 more source

Effect of Growth Medium pH of Aeropyrum pernix on Structural Properties and Fluidity of Archaeosomes

Archaea, Volume 2012, Issue 1, 2012., 2012
The influence of pH (6.0; 7.0; 8.0) of the growth medium of Aeropyrum pernix K1 on the structural organization and fluidity of archaeosomes prepared from a polar‐lipid methanol fraction (PLMF) was investigated using fluorescence anisotropy and electron paramagnetic resonance (EPR) spectroscopy.
Ajda Ota, Dejan Gmajner, Marjeta Šentjurc, Nataša Poklar Ulrih, Parkson Chong   +4 more
wiley   +1 more source

Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents

International Journal of Hypertension, Volume 2024, Issue 1, 2024.
The lipid‐based drug delivery system (LBDDS) is a well‐established technique that is anticipated to bring about comprehensive transformations in the pharmaceutical field, impacting the management and administration of drugs, as well as treatment and diagnosis.
Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al Harrasi, Renu Saharan, Geeta Aggarwal, Suresh Kumar, Renu Sehrawat, Chanchal Rani, Emanuele Pivetta   +10 more
wiley   +1 more source

Archaeosomes and Tetraether Lipid Liposome

Pharmaceutical Sciences and Research, 2012
Archaea have phytanyl ether lipids which is one of the characteristics that separates them from bacteria and eukaryotes. Some archaea have also unique membrane spanning tetrae- ther lipids (T EL); in Sulfolobus and Ihermoplasma species these TELmake up the majority of total membrane lipids.
openaire   +1 more source