Results 61 to 70 of about 293 (137)

Archaeosomes varying in lipid composition differ in receptor mediated endocytosis and differentially adjuvant immune responses to entrapped antigen [PDF]

, 2003
Archaeosomes prepared from total polar lipids extracted from six archaeal species with divergent lipid compositions had the capacity to deliver antigen for presentation via both MHC class I and class II pathways.
Sad, Subash, Dicaire, Chantal, Patel, G., Krisnan, L., Sprott, G., Fleming, L.   +5 more
core   +1 more source

Preparation and Characterization of Stealth Archaeosomes Based on a Synthetic PEGylated Archaeal Tetraether Lipid. [PDF]

J Drug Deliv, 2011
International audienceThe present studies were focused on the formation and characterization of sterically stabilized archaeosomes made from a synthetic PEGylated archaeal lipid.
Barbeau J, Cammas-Marion S, Auvray P, Benvegnu T.   +3 more
europepmc   +2 more sources

Archaeobacterial ether lipid liposomes as vaccine adjuvants

, 2003
Archaeosomes are mixed adjuvants capable of promoting strong humoral, cell-mediated (Th1), cytotoxic T-cell\u2013mediated (Th1), and cytotoxic T-cell responses to entrapped protein antigens.
Patel, G., Sprott, G., Krishnan, Lakshmi, Girishchandra B Patel, Lakshmi Krishnan, G.Dennis Sprott   +5 more
core   +1 more source

Physical Properties and Membrane Packing in Hybrid Archaeosomes [PDF]

Biophysical Journal, 2015
In this study, we have characterized the physical properties of liposomes made of archaeal bipolar tetraether lipids (BTL) and “conventional” monopolar diester lipids (termed as hybrid archaeosomes). We used the polar lipid fraction E (PLFE) isolated from the thermoacidophilic archaeon Sulfolobus acidocaldarius as the BTL component of the hybrid ...
Ayesa, Umme, Chong, Parkson L.G.
openaire   +1 more source

Formulation of a New Generation of Liposomes from Bacterial and Archeal Lipids [PDF]

, 2016
Purpose: To evaluate the application of bacterial liposomes and archaeosomes as a novel drug delivery system for in vitro cytoplasmic delivery of molecules into cancer cells.Methods: Bacterial membrane lipids were extracted using chloroform and methanol.
Kargar, Mohammad, Hashemitabar, Mahmood, Saremy, Sadegh, Ramezani, Zahra, Ameri, Abdulghani, Moghimipour, Eskandar, Handali, Somayeh   +6 more
core   +1 more source

The Role of CD8+ T Cell Phenotype and Cytotoxicity on Cancer Immunotherapy

, 2011
Cancer vaccines can fail despite the induction of large numbers of CD8+ T cells. Two categories of memory CD8+ T cells have been defined; central memory (TCM, IL-7RαhighCD44highCD62Lhigh) and effector memory (TEM, IL-7RαhighCD44highCD62Llow).
Stark, Felicity
core   +1 more source

99mTc radiolabeled archaeosomes as a potential melanoma imaging agent

Proceedings of Anticancer Research, 2018
Background: Melanoma incidence is growing worldwide. Although recent advances in imaging, there isn`t still available a specific melanoma agent that can be used for melanoma staging. Archaeosomes may be defined as liposomes composed of one or more polar lipids extracted from the Archaea domain (Archaebacterium). Objective:  As liposomes have been used
Pablo Cabral, Mirel Cabrera, Marcos Tassano, Marcelo Fernadez, Juan Pablo Gambini   +4 more
openaire   +2 more sources

Ultradeformable Archaeosomes for Needle Free Nanovaccination with Leishmania braziliensis Antigens

PLOS ONE, 2016
Total antigens from Leishmania braziliensis promastigotes, solubilized with sodium cholate (dsLp), were formulated within ultradeformable nanovesicles (dsLp-ultradeformable archaeosomes, (dsLp-UDA), and dsLp-ultradeformable liposomes (dsLp-UDL)) and topically administered to Balb/c mice.
Leticia Herminia Higa, Laura Arnal, Mónica Vermeulen, Ana Paula Perez, Priscila Schilrreff, Cecilia Mundiña‐Weilenmann, Osvaldo Yantorno, M. E. Vela, María José Morilla, Eder Lilia Romero   +9 more
openaire   +5 more sources

Surviving nebulization-induced Stress: Dexamethasone in pH-sensitive Archaeosomes

Nanomedicine, 2016
To increase the subcellular delivery of dexamethasone phosphate (DP) and stability to nebulization stress, pH-sensitive nanoliposomes (LpH) exhibiting archaeolipids, acting as ligands for scavenger receptors (pH-sensitive archaeosomes [ApH]), were prepared.The anti-inflammatory effect of 0.18 mg DP/mg total lipid, 100-150 nm DP-containing ApH ...
Altube, María Julia, Selzer, Solange Mailen, de Farias, Marcelo Alexandre, Portugal, Rodrigo Villares, Morilla, María José, Romero, Eder Lilia   +5 more
openaire   +3 more sources

Rapid clonal expansion and prolonged maintenance of memory CD8+ T cells of the effector (CD44highCD62Llow) and central (CD44highCD62Lhigh) phenotype by an archaeosome adjuvant independent of TLR2.

, 2007
Vaccines capable of eliciting long-term T cell immunity are required for combating many diseases. Live vectors can be unsafe whereas subunit vaccines often lack potency.
Krishnan, L;Gurnani, K;Dicaire, CJ;van Faassen, H;Zafer, A;Kirschning, CJ;Sad, S;Sprott, GD
core   +1 more source