Results 71 to 80 of about 269 (141)

99mTc radiolabeled archaeosomes as a potential melanoma imaging agent

Proceedings of Anticancer Research, 2018
Background: Melanoma incidence is growing worldwide. Although recent advances in imaging, there isn`t still available a specific melanoma agent that can be used for melanoma staging. Archaeosomes may be defined as liposomes composed of one or more polar lipids extracted from the Archaea domain (Archaebacterium). Objective:  As liposomes have been used
Pablo Cabral, Mirel Cabrera, Marcos Tassano, Marcelo Fernadez, Juan Pablo Gambini   +4 more
openaire   +2 more sources

Ultradeformable Archaeosomes for Needle Free Nanovaccination with Leishmania braziliensis Antigens

PLOS ONE, 2016
Total antigens from Leishmania braziliensis promastigotes, solubilized with sodium cholate (dsLp), were formulated within ultradeformable nanovesicles (dsLp-ultradeformable archaeosomes, (dsLp-UDA), and dsLp-ultradeformable liposomes (dsLp-UDL)) and topically administered to Balb/c mice.
Leticia Herminia Higa, Laura Arnal, Mónica Vermeulen, Ana Paula Perez, Priscila Schilrreff, Cecilia Mundiña‐Weilenmann, Osvaldo Yantorno, M. E. Vela, María José Morilla, Eder Lilia Romero   +9 more
openaire   +5 more sources

Surviving nebulization-induced Stress: Dexamethasone in pH-sensitive Archaeosomes

Nanomedicine, 2016
To increase the subcellular delivery of dexamethasone phosphate (DP) and stability to nebulization stress, pH-sensitive nanoliposomes (LpH) exhibiting archaeolipids, acting as ligands for scavenger receptors (pH-sensitive archaeosomes [ApH]), were prepared.The anti-inflammatory effect of 0.18 mg DP/mg total lipid, 100-150 nm DP-containing ApH ...
Altube, María Julia, Selzer, Solange Mailen, de Farias, Marcelo Alexandre, Portugal, Rodrigo Villares, Morilla, María José, Romero, Eder Lilia   +5 more
openaire   +3 more sources

An Evaluation of Novel Archaeosome Lipids and Immunostimulatory Molecules as Potential Vaccine Adjuvants.

, 2010
Peer reviewed: YesNRC publication ...
Sprott, D. G., Whitfield, D. M., Yeung, A.   +2 more
core  

Vesicular and Planar Membranes of Archaea Lipids: Unusual Physical Properties and Biomedical Applications. [PDF]

Int J Mol Sci, 2022
Chong PL, Chang A, Yu A, Mammedova A.
europepmc   +1 more source

Photoprotective archaeosomes made of lipids extracted with bio-solvents.

Processes
Archaea lipids are a source of new biomaterials for pharmaceutical and nanomedical applications; however, their classic extraction method relies on chloroform and methanol, toxic solvents that conflict with green chemistry principles. In this paper we explore the performance of an eco-friendly method for the extraction of total lipids from the ...
Yamila Roxana Simioni, Victoria Rebeca Dana González Epelboim, Gustavo Apezteguia, Leticia Herminia Higa, Eder Lilia Romero, Maria Jose Morilla   +5 more
openaire   +1 more source

Cytotoxicity and uptake of archaeosomes prepared from Aeropyrum pernix lipids

Human & Experimental Toxicology, 2013
Archaeon Aeropyrum pernix K1 is an obligate aerobic hyperthermophilic organism with C 25,25 -archeol membrane lipids with head groups containing inositol. Interactions of archaeosomes, liposomes prepared from lipids of A. pernix, with mammalian cells in vitro were studied.
T. B. Napotnik, J. Valant, D. Gmajner, PASSAMONTI, SABINA, D. Miklavcic, N. P. Ulrih   +5 more
openaire   +4 more sources

The potent adjuvant activity of archaeosomes correlates to the recruitment and activation of macrophages and dendritic cells in vivo

, 2001
The unique glycerolipids of Archaea can be formulated into vesicles (archaeosomes) with potent adjuvant activity. We studied the effect of archaeosomes on APCs to elucidate the mechanism(s) of adjuvant action.
Sad, Subash, Patel, G., Sprott, G., Krishnan, Lakshmi   +3 more
core   +1 more source

Rapid clonal expansion and prolonged maintenance of memory CD8+ T cells of the effector (CD44highCD62Llow) and central (CD44highCD62Lhigh) phenotype by an archaeosome adjuvant independent of TLR2.

, 2007
Vaccines capable of eliciting long-term T cell immunity are required for combating many diseases. Live vectors can be unsafe whereas subunit vaccines often lack potency.
Krishnan, L;Gurnani, K;Dicaire, CJ;van Faassen, H;Zafer, A;Kirschning, CJ;Sad, S;Sprott, GD
core  

Formulation of a New Generation of Liposomes from Bacterial and Archeal Lipids

, 2016
Purpose: To evaluate the application of bacterial liposomes and archaeosomes as a novel drug delivery system for in vitro cytoplasmic delivery of molecules into cancer cells.Methods: Bacterial membrane lipids were extracted using chloroform and methanol.
Kargar, Mohammad, Hashemitabar, Mahmood, Saremy, Sadegh, Ramezani, Zahra, Ameri, Abdulghani, Moghimipour, Eskandar, Handali, Somayeh   +6 more
core   +1 more source