Results 91 to 100 of about 161,658 (309)

Assessment of contemporary satellite sea ice thickness products for Arctic sea ice [PDF]

The Cryosphere, 2018
Abstract. Advances in remote sensing of sea ice over the past two decades have resulted in a wide variety of satellite-derived sea ice thickness data products becoming publicly available. Selecting the most appropriate product is challenging given end user objectives range from incorporating satellite-derived thickness information in operational ...
H. Sallila, S. L. Farrell, J. McCurry, E. Rinne   +3 more
openaire   +4 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Radiative Heating of an Ice-Free Arctic Ocean [PDF]

, 2019
During recent decades, there has been dramatic Arctic sea ice retreat. This has reduced the top-of-atmosphere albedo, adding more solar energy to the climate system.
Eisenman, I, Pistone, K, Ramanathan, V
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The emergence of a dipole-like mode in Arctic atmospheric circulation conducive to European heat waves

Communications Earth & Environment
Since the 2000s, there has been a marked acceleration in the decline of summer Arctic sea ice, accompanied by an increase in Arctic sea ice variability.
Doo Young Lee, Sang-Wook Yeh, Yong-Han Lee, Wenju Cai, Guojian Wang, Young-Min Yang   +5 more
doaj   +1 more source

The Grounding of an Ice Shelf in the Central Arctic Ocean: A Modeling Experiment [PDF]

, 2003
A numerical ice sheet model was used in a first test towards evaluating the hypothesis that, during a period of large-scale glaciation, an ice shelf emanating from the Barents/Kara Seas grounded across parts of the Lomonosov Ridge to a depth of around ...
Jakobsson, Martin, Paton, Mark, Siegert, M   +2 more
core   +1 more source

Weakening of the stratospheric polar vortex by Arctic sea-ice loss [PDF]

Successive cold winters of severely low temperatures in recent years have had critical social and economic impacts on the mid-latitude continents in the Northern Hemisphere.
Jeong, JH, Kim, BM, Kim, SJ, Min, SK, Shim, T, Son, SW, Yoon, JH, Zhang, XD   +7 more
core   +1 more source