Results 101 to 110 of about 161,658 (309)

Potential sea ice predictability and the role of stochastic sea ice strength perturbations [PDF]

, 2014
Ensemble experiments with a climate model are carried out in order to explore how incorporating a stochastic ice strength parameterization to account for model uncertainty affects estimates of potential sea ice predictability on time scales from days to ...
Goessling, Helge F., Jung, Thomas, Juricke, Stephan   +2 more
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Satellite Observation of Sea Ice Concentration Based on Chinese HY-1C/D Data

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The increasingly significant global warming has severely affected the Arctic region. The melting speed of sea ice is accelerating, and its spatial coverage is gradually shrinking, causing a series of ecological problems that cannot be ignored. Therefore,
Li Xu, Yiming Chen, Deyong Sun, Shengqiang Wang, Lijian Shi, Muhammad Bilal, Yongjun Jia, Shuyan Lang, Bin Zou   +8 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Oceanic heat advection to the Arctic in the last Millennium [PDF]

, 2011
EGU2011-8738 At present, the Arctic is responding faster to global warming than most other areas on earth, as indicated by rising air temperatures, melting glaciers and ice sheets and a decline of the sea ice cover. As part of the meridional overturning
Aagaard-Sørensen, Steffen, Budeus, Gereon, Hald, Morten, Husum, Katrine, Kandiano, Evguenia, Marchitto, Thomas M., Spielhagen, Robert F., Werner, Kirstin, Zamelczyk, Katarzyna   +8 more
core  

Arctic tides from GPS on sea-ice

Journal of Geodynamics, 2013
Abstract The presence of sea-ice in the Arctic Ocean plays a significant role in the Arctic climate. Sea-ice dampens the ocean tide amplitude with the result that global tidal models perform less accurately in the polar regions. This paper presents, a kinematic processing of global positioning system (GPS) placed on sea-ice, at six different sites ...
Kildegaard Rose, Stine, Skourup, Henriette, Forsberg, René   +2 more
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Enhanced Arctic sea-ice retreat due to pronounced pacificization effect in the Holocene

Communications Earth & Environment
Future climate confronts major challenges due to ongoing Arctic sea-ice retreat. Notably, eventful sea-ice loss in the Holocene appears comparable circumstance, but associated physics remians poorly understood.
Yuying Zhang, Limin Hu, Xun Gong, Xiaotong Xiao, Zhizheng Jia, Yanguang Liu, Jiang Dong, Anatolii S. Astakhov, Alexander Bosin, Yuri Vasilenko, Meixun Zhao, Ruediger Stein, Gerrit Lohmann, Xuefa Shi   +13 more
doaj   +1 more source

The application of ERTS imagery to monitoring Arctic sea ice [PDF]

The author has identified the following significant results. Because of the effect of sea ice on the heat balance of the Arctic and because of the expanding economic interest in arctic oil and minerals, extensive monitoring and further study of sea ice ...
Barnes, J. C., Bowley, C. J.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source