Results 131 to 140 of about 161,658 (309)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The large‐scale freshwater cycle of the Arctic [PDF]
, 2006 This paper synthesizes our understanding of the Arctic\u27s large‐scale freshwater cycle. It combines terrestrial and oceanic observations with insights gained from the ERA‐40 reanalysis and land surface and ice‐ocean models. Annual mean freshwater input
Aagaard, Knut +9 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Environmental Research LettersArctic sea-ice decline has been accelerating under greenhouse warming. In this study, we investigate the tropical precipitation response to declining Arctic sea-ice using observations and climate model simulations.
Sandeep Narayanasetti +5 more
doaj +1 more source
Passive microwave Arctic sea ice melt onset dates from the advanced horizontal range algorithm 1979-2022. [PDF]
Sci Data, 2023 Bliss AC.
europepmc +1 more source
Stepwise transition from deglacial/Early Holocene to modern-like conditions in the eastern Fram Strait, sub-Arctic north, inferred from planktic foraminifer fauna and sea surface temperatures [PDF]
, 2012 EGU2012-4750 The heat content of the Arctic Ocean is mainly controlled by the inflow of north-heading warm and saline Atlantic Water through eastern Fram Strait.
Hass, H. C. +3 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Reversibility of Arctic Sea Ice Retreat - A Multi-Scale Modeling Approach [PDF]
, 2012 Arctic summer sea ice has been retreating rapidly over past decade. Climate model projections show further retreat under typical forcing scenarios. The mode of the retreat is a matter of debate.
Mueller-Stoffels, M.
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Continuous observations of the surface energy budget and meteorology over the Arctic sea ice during MOSAiC. [PDF]
Sci Data, 2023 Cox CJ +21 more
europepmc +1 more source