Results 61 to 70 of about 161,658 (309)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Less Surface Sea Ice Melt in the CESM2 Improves Arctic Sea Ice Simulation With Minimal Non‐Polar Climate Impacts

Journal of Advances in Modeling Earth Systems, 2022
This study isolates the influence of sea ice mean state on pre‐industrial climate and transient 1850–2100 climate change within a fully coupled global model: The Community Earth System Model version 2 (CESM2).
Jennifer E. Kay, Patricia DeRepentigny, Marika M. Holland, David A. Bailey, Alice K. DuVivier, Ed Blanchard‐Wrigglesworth, Clara Deser, Alexandra Jahn, Hansi Singh, Madison M. Smith, Melinda A. Webster, Jim Edwards, Sun‐Seon Lee, Keith B. Rodgers, Nan Rosenbloom   +14 more
doaj   +1 more source

Expedition 302 geophysics: integrating past data with new results [PDF]

, 2006
In preparation for IODP Expedition 302, Arctic Coring Expedition (ACEX), a site survey database comprising geophysical and geological data from the Lomonosov Ridge was compiled.
Backman, J., Brinkhuis, H., Clemens, S., Cronin, T., Dickens, G.R., Eynaud, F., Floden, T., Gattacceca, J., Jakobsson, M., Jakobsson, M., Jordan, R.W., Kaminski, M., King, J., Koç, N., Martinez, N.C., Matthiessen, J., McInroy, D., Moore Jr., T.C., Moran, K., O'Regan, M., Onodera, J., Pälike, H., Rea, B., Rio, D., Sakamoto, T., Smith, D.C., St. John, K.E.K., Stein, R., Suto, I., Suzuki, N., Takahashi, K., Watanabe, M., Yamamoto, M.   +32 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Changes in sea-surface temperature and atmospheric circulation patterns associated with reductions in Arctic sea ice cover in recent decades [PDF]

Atmospheric Chemistry and Physics, 2018
In recent decades, the Arctic sea ice has been declining at a rapid pace as the Arctic warms at a rate of twice the global average. The underlying physical mechanisms for the Arctic warming and accelerated sea ice retreat are not fully understood.
L. Yu, S. Zhong
doaj   +1 more source

Modern spatial sea-ice variability in the central Arctic Ocean and adjacent marginal seas: Reconstruction from biomarker data [PDF]

, 2012
Sea ice is a fundamental component of Earth’s climate system, contributing to heat reduction (albedo) and deep-water formation. In order to understand processes controlling the recent dramatic reduction in Arctic sea-ice cover, it is essential to ...
Fahl, Kirsten, Meheust, Marie, Müller, Juliane, Stein, Rüdiger, Xiao, Xiaotong   +4 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The Effect of Changing Sea Ice on the Vulnerability of Arctic Coasts [PDF]

, 2014
Shorefast sea ice prevents the interaction of the land and the ocean in the Arctic winter and influences this interaction in the summer by governing the fetch.
Anderson, R S, Barnhart, Katy R, Overeem, I   +2 more
core   +3 more sources

Influence of sea ice on Arctic precipitation [PDF]

Proceedings of the National Academy of Sciences, 2015
SignificanceThere has been a growing consensus that a decrease in sea ice would cause an increase in Arctic precipitation because of the potential for increased local evaporation. We quantify the effect of sea ice on the percentage of moisture sourced from the Arctic, using measurements of the isotopic composition of precipitation at six sites across ...
Ben G, Kopec, Xiahong, Feng, Fred A, Michel, Eric S, Posmentier   +3 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source