Results 91 to 100 of about 1,749 (159)

Enhanced Chemoprevention of Prostate Cancer by Combining Arctigenin with Green Tea and Quercetin in Prostate-Specific Phosphatase and Tensin Homolog Knockout Mice

Biomolecules
The low bioavailability of most phytochemicals limits their anticancer effects in humans. The present study was designed to test whether combining arctigenin (Arc), a lignan mainly from the seed of Arctium lappa, with green tea (GT) and quercetin (Q ...
Qiongyu Hao, Susanne M. Henning, Clara E. Magyar, Jonathan Said, Jin Zhong, Matthew B. Rettig, Jaydutt V. Vadgama, Piwen Wang   +7 more
doaj   +1 more source

Enzyme-hydrolyzed fruit of Jurinea mollis: a Rich source of (-)-(8R,8’R)-Arctigenin

, 2016
In Jurinea mollis fruit, the dibenzylbutyrolactone-type lignan glycoside arctiin and its aglycone arctigenin were determined for the first time using a combination of optimized enzymatic treatment and complementary spectrometric (HPLC-MS, GC-MS) and ...
Ress Á E, Sólyomváry, Anna, Noszál, Béla, Tóth, Gergő, Horváth, Péter, Molnár-Perl I, Komjáti B, Könye, Rita, Darcsi, András, Boldizsár I, Béni, Szabolcs   +10 more
core  

Image_1_Quantitative Proteomic Analysis Reveals That Arctigenin Alleviates Concanavalin A-Induced Hepatitis Through Suppressing Immune System and Regulating Autophagy.JPEG

, 2018
Concanavalin A-induced autoimmune hepatitis is a well-established experimental model for immune-mediated liver injury. It has been widely used in the therapeutic studies of immune hepatitis. The in-depth analysis of dysregulated proteins from comparative
Tao Zhao (341704), Ningwei Zhao (5636717), Xin Li (51274), Wenkai Xia (670350), Jingang Lyu (5636714), Ge Zhou (264605), Jingchun Yao (5636711), Guimin Zhang (825720), Qin Feng (147009), Jie Yang (121778)   +9 more
core   +1 more source

Anti-austeritic Constituents of the Congolese Medicinal Plant

Natural Product Communications, 2015
In the course of our search for anticancer agents based on a novel anti-austerity strategy, we found that the CHCl 3 extract of the roots of Aflamomum melegueta (Zingiberaceae), collected in the Democratic Republic of Congo, killed PANC-1 human ...
Dya Fita Dibwe, Suresh Awale, Hiroyuki Morita, Yasuhiro Tezuka   +3 more
doaj   +1 more source

Image_2_Quantitative Proteomic Analysis Reveals That Arctigenin Alleviates Concanavalin A-Induced Hepatitis Through Suppressing Immune System and Regulating Autophagy.JPEG

, 2018
Concanavalin A-induced autoimmune hepatitis is a well-established experimental model for immune-mediated liver injury. It has been widely used in the therapeutic studies of immune hepatitis. The in-depth analysis of dysregulated proteins from comparative
Tao Zhao (341704), Xin Li (51274), Jingchun Yao, Jingang Lyu, Wenkai Xia (670350), Ge Zhou (264605), Qin Feng, Xin Li, Guimin Zhang (825720), Tao Zhao, Qin Feng (147009), Jie Yang (121778), Wenkai Xia, Ningwei Zhao (5636717), Jie Yang, Jingang Lyu (5636714), Guimin Zhang, Ningwei Zhao, Ge Zhou, Jingchun Yao (5636711)   +19 more
core   +1 more source

Elucidating the therapeutic efficacy and mechanisms of arctigenin in ameliorating renal fibrosis: a combined transcriptomic and proteomic study

Frontiers in Pharmacology
BackgroundRenal fibrosis (RF) is a refractory disease characterized by excessive deposition of extracellular matrix, leading to tissue damage and scar formation.
Yufei Yang, Yiduo Luo, Longshan Zhao, Longshan Zhao, Yukun Bo, Dongdong Zhao, Dan Yang, Jingjing Guo, Xuemiao Yang, Yanan Lv, Yi Tian, Guodong Wu, Ming An   +12 more
doaj   +1 more source

Arctigenin from Fructus arctii Exhibits Antiaging Effects via Autophagy Induction, Antioxidative Stress, and Increase in Telomerase Activity in Yeast

Antioxidants
Aging is often accompanied by irreversible decline in body function, which causes a large number of age-related diseases and brings a huge economic burden to society and families. Many traditional Chinese medicines have been known to extend lifespan, but
Siqi Chen, Yajing Li, Enchan Wu, Qing Li, Lan Xiang, Jianhua Qi   +5 more
doaj   +1 more source

Neuroprotective effect of arctigenin against neuroinflammation and oxidative stress induced by rotenone

, 2018
The present study was to investigate the neuroprotective effect of arctigenin, the major active component of a traditional Chinese medicine “Arctii Fructus”, against PD in a rat model induced by rotenone.
Kang, Tingguo, Xiaoku Ran, Na Zhang, Zhang, Na, Ran, Xiaoku, Deqiang Dou, Tingguo Kang, Dou, Deqiang   +7 more
core   +1 more source

Targeted Delivery of Arctigenin Using Sialic Acid Conjugate-Modified Liposomes for the Treatment of Breast Cancer

Molecules
Arctigenin (ATG) is a broad-spectrum antitumor drug with an excellent inhibitory effect on malignant tumors such as breast cancer, glioblastoma, liver cancer, and colon cancer.
Shunfang Liu, Yaozhen He, Minding Feng, Yongtong Huang, Wenhao Wu, Jiu Wang   +5 more
doaj   +1 more source

Radical Carboxyarylation Approach to Lignans. Total Synthesis of (-)-Arctigenin, (-)-Matairesinol, and Related Natural Products

, 2015
Total syntheses of seven biologically important lignan natural products, including (-)-arctigenin, (-)-matairesinol, and (-)α-conidendrin, by way of a highly stereoselective domino radical sequence is presented.
Sherburn, Michael, Fischer, Joshua, Reynolds, Aaron, Sharp, Lisa   +3 more
core   +1 more source