Results 81 to 90 of about 1,749 (159)

A New Paradigm for Precision Drug Delivery in Inflammatory Bowel Disease: Effective Transfer, Enhanced Retention, and Pathology‐Targeting Treatment via Biomaterials and Engineered Platforms

MedComm – Biomaterials and Applications, Volume 4, Issue 3, September 2025.
This review presents a precision delivery paradigm for inflammatory bowel disease, centered on Effective Transfer, Enhanced Retention, and Pathology‐targeting Treatment. Biomaterials and engineered platforms facilitate effective intestinal transit, prolonged mucosal retention, and respond to pathological cues, such as oxidative stress or immune ...
Ruoyi Gan, Enqi Ni, Guanyue Li, Wei Chen
wiley   +1 more source

Anti‐IgE effect of small‐molecule‐compound arctigenin on food allergy in association with a distinct transcriptome profile

, 2022
BACKGROUND: Excessive production of IgE plays a major role in the pathology of food allergy. In an attempt to identify anti-IgE natural products, Arctium Lappa was one of the most effective herbs among approximately 300 screened medicinal herbs. However,
Nowak-Wegrzyn, Anna, Liu, Changda, Srivastava, Kamal D, Changda Liu, Ying Song, Mingsan Miao, Cox, Amanda, Dunkin, David, Yang, Nan, Xiaoke Chen, Amanda Cox, Cao, Mingzhuo, Zhigang Liu, Lazarski, Christopher, Adora Lin, Zambrano, Linda, Lu Wang, Maskey, Anish, Chen, Xiaoke, Christopher Lazarski, Nan Yang, Linda Zambrano, Kamal. D. Srivastava, Anish Maskey, Huang, Weihua, Lin, Adora, Liu, Zhigang, Renna Bushko, Bushko, Renna, Anna Nowak‐Wegrzyn, David Dunkin, Weihua Huang, Xiu‐Min Li, Mingzhuo Cao, Song, Ying, Miao, Mingsan, Wang, Lu, Li, Xiu-Min   +37 more
core   +1 more source

Design and Synthesis of Novel Arctigenin Analogues for the Amelioration of Metabolic Disorders

, 2015
Analogues of the natural product (−)-arctigenin, an activator of adenosine monophosphate activated protein kinase, were prepared in order to evaluate their effects on 2-deoxyglucose uptake in L6 myotubes and possible use in ameliorating metabolic ...
Yu Shen (10486), Wenming Ren (1622371), Jian Gong (6083), Ying Leng (1613104), Limin Zeng (1622368), Shudong Duan (1622365), Suling Huang (1622374), Youhong Hu (530973), Ying Feng (151159)   +8 more
core   +1 more source

Arctigenin Attenuates Tumor Metastasis Through Inhibiting Epithelial–Mesenchymal Transition in Hepatocellular Carcinoma via Suppressing GSK3β-Dependent Wnt/β-Catenin Signaling Pathway In Vivo and In Vitro

Frontiers in Pharmacology, 2019
Arctigenin (ARG) has been reported to be a bioactive lignan from Arctium lappa exerting various activities including anti-cancer and immune-regulation.
Zheng Lu, Lingling Chang, Hongbo Zhou, Xiaoqiang Liu, Yinqian Li, Tiejun Mi, Dewen Tong   +6 more
doaj   +1 more source

Arctigenin increases hemeoxygenase-1 gene expression by modulating PI3K/AKT signaling pathway in rat primary astrocytes

, 2019
Arctigenin; Astrocyte; Hemeoxygenase-1; Nrf2/ARE axis; PI3K ...
박진선, 김희선
core   +1 more source

Arctigenin Induces an Activation Response in Porcine Alveolar Macrophage Through TLR6-NOX2-MAPKs Signaling Pathway

Frontiers in Pharmacology, 2018
Arctigenin (ARG), one of the most active ingredients abstracted from seeds of Arctium lappa L., has been proved to exert promising biological activities such as immunomodulatory, anti-viral, and anti-cancer etc.
Zheng Lu, Lingling Chang, Qian Du, Yong Huang, Xiujuan Zhang, Xingchen Wu, Jie Zhang, Ruizhen Li, Zelin Zhang, Wenlong Zhang, Xiaomin Zhao, Dewen Tong   +11 more
doaj   +1 more source

Elucidation of Arctigenin Pharmacokinetics and Tissue Distribution after Intravenous, Oral, Hypodermic and Sublingual Administration in Rats and Beagle Dogs: Integration of In Vitro and In Vivo Findings

Frontiers in Pharmacology, 2017
Although arctigenin (AG) has diverse bioactivities, such as anti-oxidant, anti-inflammatory, anti-cancer, immunoregulatory and neuroprotective activities, its pharmacokinetics have not been systematically evaluated.
Jie Li, Jie Li, Jie Li, Xin Li, Xin Li, Xin Li, Yu-Shan Ren, Yu-Shan Ren, Yuan-Yuan Lv, Yuan-Yuan Lv, Yuan-Yuan Lv, Jun-Sheng Zhang, Jun-Sheng Zhang, Jun-Sheng Zhang, Xiao-Li Xu, Xiao-Li Xu, Xiao-Li Xu, Xian-Zhen Wang, Xian-Zhen Wang, Xian-Zhen Wang, Jing-Chun Yao, Jing-Chun Yao, Jing-Chun Yao, Gui-Min Zhang, Gui-Min Zhang, Zhong Liu, Zhong Liu   +26 more
doaj   +1 more source

Isolation and Identification of Allelopathic Substances from Forsythia suspensa Leaves, and Their Metabolism and Activity

Plants
The fruit of Forsythia suspensa (Thunb.) Vahl has been used in traditional Chinese medicine as “Forsythiae fructus”. The species is also grown in parks and gardens, and on streets and building lots, as an ornamental plant, but it requires pruning.
Hisashi Kato-Noguchi, Yuga Takahashi, Shunya Tojo, Toshiaki Teruya   +3 more
doaj   +1 more source

Effects of arctigenin on osteoclast-like cell formation and cell proliferation in BMM cultures.

, 2014
(A) Chemical structures of arctigenin, arctiin, and secoisolariciresinol. (B) Effects of lignan-derived compounds on osteoclast-like cell formation in BMM cultures.
Shigetoshi Kadota (510441), Hiroyasu Esumi (392822), Naoyuki Takahashi (937), Feng Li (30515), Yasuhiro Kobayashi (510442), Nobuyuki Udagawa (934), Shunsuke Uehara (510440), Teruhito Yamashita (510439)   +7 more
core   +1 more source

pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system

International Journal of Nanomedicine, 2012
Daquan Chen,1,2 Kaoxiang Sun,1,2 Hongjie Mu,1 Mingtan Tang,3 Rongcai Liang,1,2 Aiping Wang,1,2 Shasha Zhou,1 Haijun Sun,1 Feng Zhao,1 Jianwen Yao,1 Wanhui Liu1,21School of Pharmacy, Yantai University, 2State Key Laboratory of Longacting and Targeting ...
Chen D, Sun K, Mu H, Tang M, Liang R, Wang A, Zhou S, Sun H, Zhao F, Yao J, Liu W   +10 more
doaj