Results 61 to 70 of about 1,749 (159)

Arctigenin Suppressed Epithelial-Mesenchymal Transition Through Wnt3a/β-Catenin Pathway in PQ-Induced Pulmonary Fibrosis

Frontiers in Pharmacology, 2020
Arctigenin (ATG), a major bioactive substance of Fructus Arctii, counters renal fibrosis; however, whether it protects against paraquat (PQ)-induced lung fibrosis remains unknown.
Fei Gao, Fei Gao, Fei Gao, Yun Zhang, Zhizhou Yang, Mengmeng Wang, Zhiyi Zhou, Wei Zhang, Yi Ren, Xiaoqin Han, Mei Wei, Zhaorui Sun, Shinan Nie, Shinan Nie   +13 more
doaj   +1 more source

Annexin A2 Causes Motor Incoordination via Muscle–Cerebellum Axis in Sarcopenia

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Sarcopenia is a prevalent age‐related disorder characterized by progressive muscle atrophy. Impaired balance is one of its most critical clinical consequences, often leading to falling and even bone fractures. As the cerebellum plays a central role in regulating motor coordination, elucidating the molecular mechanisms underlying ...
Xin Jiao, Zengguang Wang, Hanwen Chang, Yongjin Li, Binbin Wang, Xinfa Shao, Yuxin Zhang, Yixuan Lin, Xinlin Jia, Xianhao Zhou, Wentao Li, Dinghao Luo, Tanjun Deng, Xingzuan Lin, Chen Xu, Yaokai Gan, Dongyun Gu   +16 more
wiley   +1 more source

Antiausterity Activity of Arctigenin Enantiomers: Importance of (2,3)-Absolute Configuration

Natural Product Communications, 2014
From a MeOH extract of powdered roots of Wikstroema indica , six dibenzyl-γ-butyrolactone-type lignans with (2 S ,3 S )-absolute configuration [(+)-arctigenin (1) , (+)-matairesinol (2) , (+)-trachelogenin (3) , (+)-nortrachelogenin (4) , (+)-hinokinin ...
Suresh Awale, Mamoru Kato, Dya Fita Dibwe, Feng Li, Chika Miyoshi, Hiroyasu Esumi, Shigetoshi Kadota, Yasuhiro Tezuka   +7 more
doaj   +1 more source

Bioactive phenols in leaves of Forsythia species

International Journal of Horticultural Science, 2008
Nowadays a number of lignans (arctigenin, matairesinol, pinoresinol and phillygenin) have come to the fore in research due to their various biological activities.
É. Sedlák, L. Borsodi, E. Boldizsár, É. Preininger, M. László, É. Szőke, I. Gyurján   +6 more
doaj   +1 more source

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

Arctigenin Attenuates Breast Cancer Progression through Decreasing GM-CSF/TSLP/STAT3/β-Catenin Signaling

, 2020
Invasive breast cancer is highly regulated by tumor-derived cytokines in tumor microenvironment. The development of drugs that specifically target cytokines are promising in breast cancer treatment. In this study, we reported that arctigenin, a bioactive
Xinlin Guo, Guanjun Dong, Zhihua Li, Runping Fang, Chuanping Si, Hui Shi, Qun Ma, Zhaochen Ning, Jia Fu, Junfeng Zhang, Chunxia Li, Luping Zhao, Fenglian Yan, Jun Dai, Hui Zhang, Huabao Xiong   +15 more
core   +1 more source

Synthesis and pharmacological characterisation of arctigenin analogues as antagonists of AMPA and kainate receptors

, 2021
Arctigenin and a series of new analogues have been synthesised and then tested for their potential as AMPA and kainate receptor antagonists of human homomeric GluA1 and GluK2 receptors expressed in HEK293 cells using a Ca2+ influx assay.
Collingridge, Graham L, Jane, David E, Butts, Craig P, J Thatcher, Robert, Willis, Chris L, Mallah, Shahida, Recnik, Lisa-Maria, Molnar, Elek   +7 more
core   +1 more source

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Identification of Key Targets of Herbal Compounds for Liver Fibrosis Using Network Pharmacology Combined With Transcriptomics

Gastroenterology Research and Practice, Volume 2026, Issue 1, 2026.
Chinese herbal compound prescriptions have demonstrated efficacy in preventing and treating liver fibrosis (LF), though their mechanisms remained unclear. This study is aimed at identifying diagnostic biomarkers and elucidating the molecular mechanism underlying the effects of the TCM prescription on LF.
Chen Chen, Bo Huang, Mengting Hu, Shengpeng Yang, Bo Lan, Dejun Cui, Palash Mandal   +6 more
wiley   +1 more source

Antioxidant Capacity and Characterization of Polyphenolic Compounds in Processed Falsa (Grewia asiatica L.) Products Using LC‐ESI‐QTOF‐MS/MS Analysis

Journal of Food Processing and Preservation, Volume 2026, Issue 1, 2026.
Fruits provide abundant vitamins, minerals, dietary fiber, and natural antioxidants. Falsa (Grewia asiatica), a lesser‐known berry fruit, is gaining attention owing to its diverse bioactive compounds and potential health‐promoting properties. This study aimed to evaluate the polyphenol content and antioxidant activity of processed products made from ...
X. Qin, A. Din, M. R. Khan, M. A. Shabbir, A. Rafi, A. Siddiqa, O. T. Agar, A. Beyatli, A. Imran, F. Ahmadi, H. A. R. Suleria, Essam Hebishy   +11 more
wiley   +1 more source