Results 111 to 120 of about 12,599,671 (317)
Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar +13 morewiley +1 more sourceEmerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger +3 morewiley +1 more sourceGut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte +7 morewiley +1 more sourceIn vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni +14 morewiley +1 more sourceAggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera +11 morewiley +1 more sourceScreening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto +12 morewiley +1 more sourceTRY plant trait database - enhanced coverage and open access [PDF]
, 2020 Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits ...Aakala, T, Abedi, M, Acosta, ATR, Adamidis, GC, Adamson, K, Aiba, M, Albert, CH, Alcantara, JM, Alcazar, CC, Aleixo, I, Ali, H, Amiaud, B, Ammer, C, Amoroso, MM, Anand, M, Anderson, C, Anh, TDL, Anten, N, Antos, J, Apgaua, DMG, Ashman, TL, Asmara, DH, Asner, GP, Aspinwall, M, Atkin, O, Aubin, I, Baastrup-Spohr, L, Bahalkeh, K, Bahn, M, Baker, T, Baker, WJ, Bakker, JP, Baldocchi, D, Baltzer, J, Banerjee, A, Baranger, A, Barlow, J, Barneche, DR, Baruch, Z, Bastianelli, D, Battles, J, Bauerle, W, Bauters, M, Bazzato, E, Beckmann, M, Beeckman, H, Beierkuhnlein, C, Bekker, R, Belfry, G, Belluau, M, Beloiu, M, Benavides, R, Benomar, L, Berdugo-Lattke, ML, Berenguer, E, Bergamin, R, Bergmann, J, Berner, L, Bernhardt-Romermann, M, Bigler, C, Bjorkman, AD, Blackman, C, Blanco, C, Blonder, B, Blumenthal, D, Bocanegra-Gonzalez, KT, Boeckx, P, Bohlman, S, Bohning-Gaese, K, Boisvert-Marsh, L, Bond, W, Bond-Lamberty, B, Bonisch, G, Boom, A, Boonman, CCF, Bordin, K, Boughton, EH, Boukili, V, Bowman, DMJS, Bravo, S, Brendel, MR, Broadley, MR, Brown, KA, Bruelheide, H, Brumnich, F, Bruun, HH, Bruy, D, Buchanan, SW, Bucher, SF, Buchmann, N, Buitenwerf, R, Bunker, DE, Burger, J, Burrascano, S, Burslem, DFRP, Butterfield, BJ, Byun, C, Caccianiga, M, Cadotte, M, Cailleret, M, Camac, J, Camarero, JJ, Campany, C, Campetella, G, Campos, JA, Cano-Arboleda, L, Canullo, R, Carbognani, M, Carlucci, MB, Carvalho, F, Casanoves, F, Castagneyrol, B, Catford, JA, Cavender-Bares, J, Cerabolini, BEL, Cervellini, M, Chacon-Madrigal, E, Chapin, FS, Chapin, K, Chelli, S, Chen, AP, Chen, SC, Cherubini, P, Chianucci, F, Choat, B, Chung, KS, Chytry, M, Ciccarelli, D, Coll, L, Collins, CG, Conti, L, Coomes, D, Cornelissen, JHC, Cornwell, WK, Corona, P, Coyea, M, Craine, J, Craven, D, Cromsigt, JPGM, Csecserits, A, Cufar, K, Cuntz, M, da Silva, AC, Dahlin, KM, Dainese, M, Dalke, I, Dalle Fratte, M, Danihelka, J, Dannoura, M, Dawson, S, de Beer, AJ, de Dios, VR, De Frutos, A, de Gasper, AL, De Long, JR, Dechant, B, Delagrange, S, Delpierre, N, Derroire, G, Dias, AS, Diaz, S, Diaz-Toribio, MH, Dimitrakopoulos, PG, Dobrowolski, M, Doktor, D, Domingues, TF, Dong, N, Dransfield, J, Dressler, S, Drevojan, P, Duarte, L, Ducouret, E, Dullinger, S, Durka, W, Duursma, R, Dymova, O, E-Vojtko, A, Eckstein, RL, Ejtehadi, H, Elser, J, Emilio, T, Engemann, K, Erfanian, MB, Erfmeier, A, Esquivel-Muelbert, A, Esser, G, Estiarte, M, Fagan, WF, Fagundez, J, Falster, DS, Fan, Y, Fang, JY, Farris, E, Fazlioglu, F, Feng, YH, Fernandez-Mendez, F, Ferrara, C, Ferreira, J, Fidelis, A, Finegan, B, Firn, J, Flowers, TJ, Flynn, DFB, Fontana, V, Forey, E, Forgiarini, C, Francois, L, Frangipani, M, Frank, D, Frenette-Dussault, C, Freschet, GT, Fry, EL, Fyllas, NM, Gachet, S, Gallagher, R, Ganade, G, Ganga, F, Garcia-Palacios, P, Gargaglione, V, Garnier, E, Garrido, JL, Garvizu, GS, Gea-Izquierdo, G, Gibson, D, Gillison, AN, Giroldo, A, Glasenhardt, MC, Gleason, S, Gliesch, M, Goldberg, E, Goldel, B, Gonzalez-Akre, E, Gonzalez-Andujar, JL, Gonzalez-Melo, A, Gonzalez-Robles, A, Graae, BJ, Granda, E, Graves, S, Green, WA, Gregor, T, Gross, N, Guerin, GR, Gunther, A, Gutierrez, AG, Haddock, L, Haines, A, Hall, J, Hambuckers, A, Han, WX, Harrison, SP, Hattingh, W, Hawes, JE, He, PC, He, TH, Heberling, JM, Helm, A, Hempel, S, Hentschel, J, Herault, B, Heres, AM, Herz, K, Heuertz, M, Hickler, T, Hietz, P, Higuchi, P, Hipp, AL, Hirons, A, Hock, M, Hogan, JA, Holl, K, Honnay, O, Hornstein, D, Hou, EQ, Hough-Snee, N, Hovstad, KA, Ichie, T, Igic, B, Illa, E, Isaac, M, Ishihara, M, Ivanov, L, Ivanova, L, Iversen, CM, Izquierdo, J, Jackson, B, Jackson, RB, Jactel, H, Jagodzinski, AM, Jandt, U, Jansen, S, Jenkins, T, Jentsch, A, Jespersen, JRP, Jiang, GF, Johansen, JL, Johnson, D, Jokela, EJ, Joly, CA, Jordan, GJ, Joseph, GS, Junaedi, D, Junker, RR, Justes, E, Kabzems, R, Kane, J, Kaplan, Z, Kattenborn, T, Kattge, J, Kavelenova, L, Kearsley, E, Kempel, A, Kenzo, T, Kerkhoff, A, Khalil, MI, Kinlock, NL, Kissling, WD, Kitajima, K, Kitzberger, T, Kjoller, R, Klein, T, Kleyer, M, Klimesova, J, Klipel, J, Kloeppel, B, Klotz, S, Knops, JMH, Kohyama, T, Koike, F, Kollmann, J, Komac, B, Komatsu, K, Konig, C, Kraft, NJB, Kramer, K, Kreft, H, Kuhn, I, Kumarathunge, D, Kuppler, J, Kurokawa, H, Kurosawa, Y, Kuyah, S, Laclau, JP, Lafleur, B, Lallai, E, Lamb, E, Lamprecht, A, Larkin, DJ, Laughlin, D, Lavorel, S, Le Bagousse-Pinguet, Y, le Maire, G, le Roux, E, le Roux, PC, Leadley, P, Lee, T, Lens, F, Lewis, SL, Lhotsky, B, Li, XE, Li, YZ, Lichstein, JW, Liebergesell, M, Lim, JY, Lin, YS, Linares, JC, Liu, CJ, Liu, DJ, Liu, U, Livingstone, S, Llusia, J, Lohbeck, M, Lopez-Garcia, A, Lopez-Gonzalez, G, Lososova, Z, Louault, F, Lukacs, BA, Lukes, P, Luo, YJ, Lussu, M, Ma, SY, Mack, M, Maire, V, Makela, A, Makinen, H, Malhado, ACM, Mallik, A, Manning, P, Manzoni, S, Marchetti, Z, Marchino, L, Marcilio-Silva, V, Marcon, E, Marignani, M, Markesteijn, L, Marques, M, Martin, A, Martinez-Garza, C, Martinez-Vilalta, J, Maskova, T, Mason, K, Mason, N, Massad, TJ, Masse, J, Mayrose, I, Mazzochini, GG, McCarthy, J, McCormack, ML, McCulloh, K, McFadden, IR, McGill, BJ, McPartland, MY, Medeiros, JS, Medlyn, B, Meerts, P, Mehrabi, Z, Meir, P, Melo, FPL, Mencuccini, M, Meredieu, C, Messier, J, Meszaros, I, Metsaranta, J, Michaletz, ST, Michelaki, C, Migalina, S, Milla, R, Miller, JED, Minden, V, Ming, R, Mokany, K, Moles, AT, Molnar, VA, Molofsky, J, Molz, M, Montgomery, RA, Monty, A, Moravcova, L, Moreno-Martinez, A, Moretti, M, Mori, AS, Mori, S, Morris, D, Morrison, J, Mucina, L, Mueller, S, Muir, CD, Muller, SC, Munoz, F, Myers-Smith, IH, Myster, RW, Nagano, M, Naidu, S, Narayanan, A, Natesan, B, Negoita, L, Nelson, AS, Neuschulz, EL, Ni, J, Niedrist, G, Nieto, J, Niinemets, U, Nolan, R, Nottebrock, H, Nouvellon, Y, Novakovskiy, A, Nystuen, KO, O'Grady, A, O'Hara, K, O'Reilly-Nugent, A, Oakley, S, Oberhuber, W, Ohtsuka, T, Oliveira, R, Ollerer, K, Olson, ME, Onipchenko, V, Onoda, Y, Onstein, RE, Ordonez, JC, Osada, N, Ostonen, I, Ottaviani, G, Otto, S, Overbeck, GE, Ozinga, WA, Pahl, AT, Paine, CET, Pakeman, RJ, Papageorgiou, AC, Parfionova, E, Partel, M, Patacca, M, Paula, S, Paule, J, Pauli, H, Pausas, JG, Peco, B, Penuelas, J, Perea, A, Pereira, CMR, Peri, PL, Petisco-Souza, AC, Petraglia, A, Petritan, AM, Phillips, OL, Pierce, S, Pillar, VD, Pinho, BX, Pisek, J, Pomogaybin, A, Poorter, H, Portsmuth, A, Poschlod, P, Potvin, C, Pounds, D, Powell, AS, Power, SA, Prentice, IC, Prinzing, A, Puglielli, G, Pysek, P, Raevel, V, Rammig, A, Ransijn, J, Ray, CA, Reich, PB, Reichstein, M, Reid, DEB, Rejou-Mechain, M, Ribeiro, S, Richardson, S, Riibak, K, Rillig, MC, Riviera, F, Robert, EMR, Roberts, S, Robroek, B, Roddy, A, Rodrigues, AV, Rogers, A, Rollinson, E, Rolo, V, Romermann, C, Ronzhina, D, Roscher, C, Rosell, JA, Rosenfield, MF, Rossi, C, Roy, DB, Royer-Tardif, S, Ruger, N, Ruiz-Peinado, R, Rumpf, SB, Rusch, GM, Ryo, M, Sack, L, Saldana, A, Salgado-Negret, B, Salguero-Gomez, R, Santa-Regina, I, Santacruz-Garcia, AC, Santos, J, Sardans, J, Scalon, MC, Schamp, B, Scherer-Lorenzen, M, Schleuning, M, Schmid, B, Schmidt, M, Schmitt, S, Schneider, JV, Schowanek, SD, Schrader, J, Schrodt, F, Schuldt, B, Schurr, F, Semchenko, M, Seymour, C, Sfair, JC, Sharpe, JM, Sheppard, CS, Sheremetiev, S, Shiodera, S, Shipley, B, Shovon, TA, Siebenkas, A, Sierra, C, Silva, M, Silva, V, Sitzia, T, Sjoman, H, Slot, M, Smith, NG, Sodhi, D, Soltis, D, Soltis, P, Somers, B, Sonnier, G, Sorensen, MV, Sosinski, EE, Soudzilovskaia, NA, Souza, AF, Spasojevic, M, Sperandii, MG, Stan, AB, Stegen, J, Steinbauer, K, Stephan, JG, Sterck, F, Stojanovic, DB, Strydom, T, Suarez, ML, Svenning, JC, Svitkova, I, Svitok, M, Svoboda, M, Swaine, E, Swenson, N, Tabarelli, M, Takagi, K, Tappeiner, U, Tarifa, R, Tarin, T, Tautenhahn, S, Tauugourdeau, S, Tavsanoglu, C, te Beest, M, Tedersoo, L, Thiffault, N, Thom, D, Thomas, E, Thompson, K, Thornton, PE, Thuiller, W, Tichy, L, Tissue, D, Tjoelker, MG, Tng, DYP, Tobias, J, Torok, P, Torres-Ruiz, JM, Tothmeresz, B, Treurnicht, M, Trivellone, V, Trolliet, F, Trotsiuk, V, Tsakalos, JL, Tsiripidis, I, Tysklind, N, Umehara, T, Usoltsev, V. A., Vadeboncoeur, M, Vaezi, J, Valderrama, MY, Valladares, F, Vamosi, J, van Bodegom, PM, van Breugel, M, Van Cleemput, E, van de Weg, M, van der Merwe, S, van der Plas, F, van der Sande, MT, van Kleunen, M, Van Meerbeek, K, Vanderwel, M, Vanselow, KA, Varhammar, A, Varone, L, Vassilev, K, Vellend, M, Veneklaas, EJ, Verbeeck, H, Verheyen, K, Vibrans, A, Vieira, I, Villacis, J, Violle, C, Vivek, P, Wagner, K, Waldram, M, Waldron, A, Walker, AP, Waller, M, Walther, G, Wang, F, Wang, H, Wang, WQ, Watkins, H, Watkins, J, Weber, U, Weedon, JT, Wei, LP, Weigelt, P, Weiher, E, Wells, AW, Wellstein, C, Wenk, E, Werner, GDA, Westoby, M, Westwood, A, White, PJ, Whitten, M, Williams, M, Winkler, DE, Winter, K, Wirth, C, Womack, C, Wright, IJ, Wright, J, Wright, SJ, Ximenes, F, Yamada, T, Yamaji, K, Yanai, R, Yankov, N, Yguel, B, Zanini, KJ, Zanne, AE, Zeleny, D, Zhao, YP, Zheng, J, Zheng, JM, Zieminska, K, Zirbel, CR, Zizka, G, Zo-Bi, IC, Zotz, G +727 morecore Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourceLiquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen +2 morewiley +1 more source