Results 21 to 30 of about 36,753 (202)

Prequential AUC: properties of the area under the ROC curve for data streams with concept drift

Knowledge and Information Systems, 2017
Modern data-driven systems often require classifiers capable of dealing with streaming imbalanced data and concept changes. The assessment of learning algorithms in such scenarios is still a challenge, as existing online evaluation measures focus on efficiency, but are susceptible to class ratio changes over time. In case of static data, the area under
Dariusz Brzezinski, Jerzy Stefanowski
openaire   +1 more source

Nonparametric bootstrap methods for interval estimation of the area under the ROC curve with correlated diagnostic test data: application to whole-virus ELISA testing in swine

Frontiers in Veterinary Science, 2023
Developing and evaluating novel diagnostic assays are crucial components of contemporary diagnostic research. The receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC) are frequently used to evaluate diagnostic assays ...
Jinji Pang, Jinji Pang, Wangqian Ju, Michael Welch, Phillip Gauger, Peng Liu, Qijing Zhang, Chong Wang, Chong Wang   +8 more
doaj   +1 more source

A molecular computational model improves the preoperative diagnosis of thyroid nodules

BMC Cancer, 2012
Background Thyroid nodules with indeterminate cytological features on fine needle aspiration (FNA) cytology have a 20% risk of thyroid cancer. The aim of the current study was to determine the diagnostic utility of an 8-gene assay to distinguish benign ...
Tomei Sara, Marchetti Ivo, Zavaglia Katia, Lessi Francesca, Apollo Alessandro, Aretini Paolo, Di Coscio Giancarlo, Bevilacqua Generoso, Mazzanti Chiara   +8 more
doaj   +1 more source

A Pipeline-based Framework for Early Prediction of Diabetes [PDF]

مجله انفورماتیک سلامت و زیست پزشکی, 2023
Introduction: Diabetes is a chronic disease worldwide, with an increasing annual death rate. Many health professionals seek innovative ways to detect and treat it early. Rapid advances in machine learning have improved disease diagnosis. However, because
Karlo Abnoosian, Rahman Farnoosh, Mohammad Hassan Behzadi   +2 more
doaj  

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Comparing the Relative Efficacy of Generalized Estimating Equations, Latent Growth Curve Modeling, and Area Under the Curve with a Repeated Measures Discrete Ordinal Outcome Variable

Stats
Researchers are often interested in how changes in one variable influence changes in a second variable, requiring the repeated measures of two variables.
Daniel Rodriguez, Ryan Verma, Juliana Upchurch   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Towards non-invasive diagnosis of glioblastoma: identifying metabolic biomarkers in liquid biopsies using a ROC-based approach

Discover Oncology
For over seven decades, the World Health Organization (WHO) has classified central nervous system tumors primarily based on histological criteria. While recent updates have incorporated molecular genetics and histochemistry, this approach still overlooks
Margareth Borges Coutinho Gallo
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source