Results 31 to 40 of about 36,753 (202)

A Multi-Criteria Decision Analysis (MCDA) Approach for Landslide Susceptibility Mapping of a Part of Darjeeling District in North-East Himalaya, India

Applied Sciences, 2023
Landslides are the nation’s hidden disaster, significantly increasing economic loss and social disruption. Unfortunately, limited information is available about the depth and extent of landslides.
Abhik Saha, Vasanta Govind Kumar Villuri, Ashutosh Bhardwaj, Satish Kumar   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Receiver operating characteristic curve

Current Medicine Research and Practice, 2012
A receiver operating characteristic (ROC) curve is a plot of tradeoff between sensitivity and specificity. It is a plot that evaluates a diagnostic test for a continuous variable between diseased and non-diseased subjects.
Anita Singh, Vivek Choudhury, Satish Saluja   +2 more
doaj  

Evaluation of everolimus pharmacokinetic monitoring based on trough concentration and area under the blood concentration time curve in kidney transplantation

BMC Nephrology
Background Everolimus (EVR) is widely used in kidney transplantation; however, the optimal sampling time point for therapeutic drug monitoring and the relationship between EVR exposure and adverse events under tacrolimus-based regimens remain unclear ...
Shota Fukae, Yoichi Kakuta, Soichi Matsumura, Ryo Tanaka, Masataka Kawamura, Shigeaki Nakazawa, Norio Nonomura   +6 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Feasibility of vancomycin AUC24 monitoring using peak and trough concentrations in pediatric patients: a prospective multicenter study

Frontiers in Pharmacology
BackgroundVancomycin remains a key medication in treating infections in pediatric patients, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA).
Majed H. Nahari, Majed H. Nahari, Abdullah Alsultan, Renad A. Alshuraim, Abdullah Altuwayjiri, Sultan Alotaibi, Majed Aljeraisy, Majed Aljeraisy   +7 more
doaj   +1 more source

Evaluating student levelling based on machine learning model’s performance

Discover Internet of Things, 2022
In this paper, a novel application of machine learning algorithms is presented for student levelling. In multicultural countries such as UAE, there are various education curriculums where the sector of private schools and quality assurance is supervising
Shatha Ghareeb, Abir Jaafar Hussain, Dhiya Al-Jumeily, Wasiq Khan, Rawaa Al-Jumeily, Thar Baker, Ahmed Al Shammaa, Mohammed Khalaf   +7 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

The categorisation of the Short Warwick Edinburgh Mental Wellbeing Scale scores: an exploration from an epidemiological perspective

Frontiers in Psychiatry
BackgroundThere has been a notable increase in the utilisation of SWEMWBS as a measure of mental well-being globally. To enhance its interpretability for both healthcare professionals and laypeople, categorising SWEMWBS scores is considered beneficial ...
Lawrence T. Lam, Lawrence T. Lam, Lawrence T. Lam, Mary K. Lam   +3 more
doaj   +1 more source