Results 61 to 70 of about 3,553 (177)

Pathogenesis of Lassa Fever

Viruses, 2012
Lassa virus, an Old World arenavirus (family Arenaviridae), is the etiological agent of Lassa fever, a severe human disease that is reported in more than 100,000 patients annually in the endemic regions of West Africa with mortality rates for ...
David H. Walker, Nadezhda E. Yun
doaj   +1 more source

Recent Discoveries of Novel Mammarenaviruses Infecting Humans and Other Mammals in Asia and Southeast Asia

Virulence, 2023
Mammarenaviruses, a genus of the family Arenaviridae, are capable of infecting mammals and are primarily found in rodent reservoirs worldwide. Mammarenaviruses can be transmitted to humans through contact with infected rodents, and though infection is ...
Brigitte Flannery, Michaela Cain, Hinh Ly   +2 more
doaj   +1 more source

Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High‐Throughput Sequencing Data Mining

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Analysis of 57 536 high‐throughput sequencing datasets uncovers a vast, hidden world of viruses in wildlife. The researchers reveal significant geographic and host‐specific patterns of viruses, and their surprising cross‐species transmissions, such as avian flu viruses infecting goats.
Hai Wang, Yafei Meng, Xiaoyuan Chen, Xinyuan Cui, Qian Zuo, Na Han, Xianghui Liang, Xuejuan Shen, Caiwu Li, Desheng Li, Fumin Wang, Liangping He, Rujian Chen, Xingbang Lu, Wenjie You, Aiping Wu, Rui‐Ai Chen, Wu Chen, Chan Ding, Yongyi Shen   +19 more
wiley   +1 more source

Bear Canyon Virus: An Arenavirus Naturally Associated with the California Mouse (Peromyscus californicus)

Emerging Infectious Diseases, 2002
Thirty-four rodents captured in southern California were studied to increase our knowledge of the arenaviruses indigenous to the western United States.
Charles F. Fulhorst, Stephen G. Bennett, Mary L. Milazzo, Hugh L. Murray, James P. Webb, Maria N.B. Cajimat, Robert D. Bradley   +6 more
doaj   +1 more source

LUJO HEMORRHAGIC FEVER

Вопросы вирусологии, 2017
Lujo hemorrhagic fever (LHF) is a viral disease accompanied with fever, headache, vomiting, diarrhea, arthralgia, myalgia and numerous signs of hemorrhagic syndrome. LHF causes a clinical syndrome remarkably similar to Lassa hemorrhagic fever.
T. E. Sizikova, V. N. Lebedev, S. I. Syromyatnikova, S. V. Borisevich   +3 more
doaj   +1 more source

A Mutation‐Based Reverse Vaccinology Approach Considering Variability in Epitopes to Combat Multi‐Strains: A Study Using Glycoprotein of LASV

Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT Lassa virus (LASV) remains a persistent threat to public health, and to combat this, various therapeutics have been developed, but their effectiveness is limited due to the virus's strain variability. Therefore, mutation‐based reverse vaccinology approaches were implemented to formulate an epitope‐based vaccine against the LASV, considering ...
Saurav Kumar Mishra, Rajesh B. Patil, Amdola Tshering Sherpa, Mohammad Borhan Uddin, Md. Harun‐Or‐Rashid, Muniruddin Ahmed, Turki M. Dawoud, John J. Georrge   +7 more
wiley   +1 more source

Viral hemorrhagic fevers - a recurrent public health threat

Health Problems of Civilization, 2021
Viral hemorrhagic fevers (VHFs) caused by viruses are severe infectious diseases that lead to serious disturbances of the body’s homeostasis, in most cases accompanied by symptoms of hemorrhagic diathesis.
Marcin Weiner, Karolina Tarasiuk
doaj   +1 more source

The Biological Characteristics and Mouse Model of Lassa Virus From the First Imported Case in China

MedComm, Volume 6, Issue 8, August 2025.
This is the first case of Lassa fever being introduced to China. A strain of the Lineage IV LASV was successfully isolated, and genomic and mutation analysis were conducted. Infection models were constructed using BALB/c, C57BL/6, and AG129 mice, which were successfully established.
Yanan Zhou, Junbin Wang, Ranran Cao, Yun Yang, Yuliang Feng, Cong Tang, Hao Yang, Qing Huang, Wenhai Yu, Haixuan Wang, Jiandong Shi, Kaiyun Ding, Longhai Yuan, Qing Dai, Xingping Zhao, Haiyan Li, Mengli Yang, Fangyu Luo, Fanli Zhu, Yong Zhang, Daoju Wu, Xiaorong Yang, Shuaiyao Lu, Qiangming Sun, Li Zhang, Youchun Wang   +25 more
wiley   +1 more source

Marburg Virus Disease: A Narrative Review

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Arash Letafati, Somayeh Sadat Hosseini Fakhr, Ali Qaraee Najafabadi, Negin Karami, Hassan Karami   +4 more
wiley   +1 more source

Single Nucleoprotein Residue Modulates Arenavirus Replication Complex Formation

mBio, 2015
The Arenaviridae are enveloped, negative-sense RNA viruses with several family members that cause hemorrhagic fevers. This work provides immunofluorescence evidence that, unlike those of New World arenaviruses, the replication and transcription complexes
Kristeene A. Knopp, Tuan Ngo, Paul D. Gershon, Michael J. Buchmeier   +3 more
doaj   +1 more source