Results 71 to 80 of about 2,952 (159)

Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses

Vaccines, 2019
The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo, Slobodan Paessler, Cheng Huang   +2 more
doaj   +1 more source

Detection of Latino virus (Arenaviridae: Mammarenavirus) naturally infecting Calomys callidus

Acta Tropica, 2018
Mammarenavirus species are associated with a specific rodent host species, although an increasing number of virus has been associated to more than one host, suggesting that co-evolution is less robust than initially thought. There are few eco-epidemiological studies of South America mammarenaviruses in non-endemic areas of Arenavirus Hemorrhagic Fever,
Jorlan, Fernandes, Renata Carvalho, de Oliveira, Alexandro, Guterres, Débora Ferreira, Barreto-Vieira, Ana Claudia Pereira, Terças, Bernardo Rodrigues, Teixeira, Marcos Alexandre Nunes, da Silva, Gabriela Cardoso, Caldas, Janice Mery Chicarino, de Oliveira Coelho, Ortrud Monika, Barth, Paulo Sergio, D'Andrea, Cibele Rodrigues, Bonvicino, Elba Regina Sampaio, de Lemos   +12 more
openaire   +2 more sources

Host Cell Factors as Antiviral Targets in Arenavirus Infection

Viruses, 2012
Among the members of the Arenaviridae family, Lassa virus and Junin virus generate periodic annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of West Africa and Argentina, respectively.
Elsa B. Damonte, Luis A. Scolaro, Cybele C. García, Viviana Castilla, Florencia N. Linero, Federico Giovannoni, Claudia S. Sepúlveda   +6 more
doaj   +1 more source

Transcriptional analysis of antiviral small molecule therapeutics as agonists of the RLR pathway

Genomics Data, 2016
The recognition of pathogen associated molecular patterns (PAMPs) by pattern recognition receptors (PRR) during viral infection initiates the induction of antiviral signaling pathways, including activation of the Interferon Regulator Factor 3 (IRF3).
R.R. Green, C. Wilkins, S. Pattabhi, R. Dong, Y. Loo, M. Gale, Jr   +5 more
doaj   +1 more source

Cellular endosomal potassium ion flux regulates arenavirus uncoating during virus entry

mBio
Lymphocytic choriomeningitis virus (LCMV) is an enveloped and segmented negative-sense RNA virus classified within the Arenaviridae family of the Bunyavirales order.
Amelia B. Shaw, Hiu Nam Tse, Owen Byford, Grace Plahe, Alex Moon-Walker, Samantha E. Hover, Erica Ollmann Saphire, Sean P. J. Whelan, Jamel Mankouri, Juan Fontana, John N. Barr   +10 more
doaj   +1 more source

Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans

Cell Reports
Summary: Viral pandemics and epidemics pose a significant global threat. While macaque models of viral disease are routinely used, it remains unclear how conserved antiviral responses are between macaques and humans.
Kalani Ratnasiri, Hong Zheng, Jiaying Toh, Zhiyuan Yao, Veronica Duran, Michele Donato, Mario Roederer, Megha Kamath, John-Paul M. Todd, Matthew Gagne, Kathryn E. Foulds, Joseph R. Francica, Kizzmekia S. Corbett, Daniel C. Douek, Robert A. Seder, Shirit Einav, Catherine A. Blish, Purvesh Khatri   +17 more
doaj   +1 more source

Tracing the Evolution and Recombination Events of Neurotropic Arenaviridae Viruses: a Bioinformatics Approach

Neurosignals
Lassa virus is a member of the Arenaviridae family, a major cause of viral hemorrhagic fever. This virus is associated with severe neurological complications in a select group of patients. The evolutionary mechanisms behind genetic diversity, its adaptation, and its potential neuropathogenicity are still poorly understood.
Meaad Hussein, Al-Abadi, Bashar Talib Hameed, Al-Nuaimi   +1 more
openaire   +2 more sources

The Adaptive Immune Response against Bunyavirales

Viruses
The Bunyavirales order includes at least fourteen families with diverse but related viruses, which are transmitted to vertebrate hosts by arthropod or rodent vectors.
Reem Alatrash, Bobby Brooke Herrera
doaj   +1 more source

Progress toward the development of Lassa vaccines

Expert Review of Vaccines
Hinh Ly
doaj   +1 more source

When zoonosis mimics autoimmunity: arenavirus spillover, gut dysbiosis, and the case for community-level early warning systems. [PDF]

Ann Med Surg (Lond)
Sanan A, Tanveer M, Batool ST, Sadat SH.
europepmc   +1 more source