Novel relatives of Mecsek Mountains mammarenavirus (family Arenaviridae) in hedgehogs living in different sampling areas in Hungary [PDF]
Scientific ReportsMammarenaviruses (genus Mammarenavirus, family Arenaviridae) are rodent-borne zoonotic viruses consisting of 52 viral species, including ten that are pathogenic to humans.
Àkos Boros +2 more
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Progress in Anti-Mammarenavirus Drug Development
Viruses, 2021 Mammarenaviruses are prevalent pathogens distributed worldwide, and several strains cause severe cases of human infections with high morbidity and significant mortality.
Juan De La Torre +2 more
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Genomic characterization of Wenzhou mammarenavirus detected in wild rodents in Guangzhou City, China
One Health, 2021 Wenzhou mammarenavirus (WENV) is a zoonotic pathogen newly discovered in east and southeast Asia. WENV has been found in wild rodent animals around the world while its standing is barely understood in Guangzhou city, where is known as a region of ...
Jian-Yong Wu, Cheng Guo, Yao Xia
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Viruses, 2022 Highly pathogenic Arenaviruses, like the Lassa Virus (LASV), pose a serious public health threat in affected countries. Research and development of vaccines and therapeutics are urgently needed but hampered by the necessity to handle these pathogens ...
Stephanie Wurr +2 more
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A New Transferrin Receptor Aptamer Inhibits New World Hemorrhagic Fever Mammarenavirus Entry
Molecular Therapy - Nucleic Acids, 2016 Pathogenic New World hemorrhagic fever mammarenaviruses (NWM) utilize Glycoprotein 1 (GP1) to target the apical domain of the human transferrin receptor (hTfR) for facilitating cell entry. However, the conservation between their GP1s is low.
Erik Snapp +2 more
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Mammarenaviruses depend on endogenous fatty acid synthesis in cell culture systems [PDF]
Journal of Lipid ResearchLassa virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are Old World mammarenaviruses that, like all viruses, rely on host-derived biological molecules to complete their replication cycle.
Joseph Thomas Noble +10 more
doaj +2 more sources
Burden of rodent-borne viruses in rodents and zoonotic risk in humans in Cambodia [PDF]
Microbiology SpectrumRodent-borne viruses, including orthohantaviruses, mammarenaviruses, and rat hepatitis virus (HEV-C), pose significant health threats to humans, causing severe diseases such as hemorrhagic fevers, respiratory illness, and hepatitis.
Julia Guillebaud +23 more
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Mammarenavirus Z Protein Myristoylation and Oligomerization Are Not Required for Its Dose-Dependent Inhibitory Effect on vRNP Activity [PDF]
BioChemBackground/Objectives: N-Myristoyltransferase inhibitors (NMTi) represent a novel antiviral strategy against mammarenaviruses such as Lassa and Junin viruses.
Haydar Witwit, Juan C. de la Torre
doaj +2 more sources
Population Structure of Lassa Mammarenavirus in West Africa
Viruses, 2020 Lassa mammarenavirus (LASV) is the etiologic agent of Lassa fever. In endemic regions in West Africa, LASV genetic diversity tends to cluster by geographic area.
Diego Forni +2 more
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Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein. [PDF]
PLoS PathogensSeveral Old World and New World Mammarenavirus are responsible for hemorrhagic fever in humans. These enveloped viruses have a bi-segmented ambisense RNA genome that encodes four proteins.
Xavier Carnec +7 more
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