Results 31 to 40 of about 12,650 (152)

Molecular detection and genetic characterization of Wenzhou virus in rodents in Guangzhou, China

BMC Veterinary Research, 2021
Background Wenzhou virus (WENV), a newly discovered mammarenavirus in rodents, is associated with fever and respiratory symptoms in humans. This study was aimed to detect and characterize the emerging virus in rodents in Guangzhou, China. Results A total
Nina Wang, Lichao Yang, Guohui Li, Xu Zhang, Jianwei Shao, Jun Ma, Shouyi Chen, Quan Liu   +7 more
doaj   +1 more source

Presentation of antigen on extracellular vesicles using transmembrane domains from viral glycoproteins for enhanced immunogenicity

Journal of Extracellular Vesicles, Volume 11, Issue 3, March 2022., 2022
Abstract A vaccine antigen, when launched as DNA or RNA, can be presented in various forms, including intracellular, secreted, membrane‐bound, or on extracellular vesicles (EVs). Whether an antigen in one or more of these forms is superior in immune induction remains unclear.
Kai Hu, Paul F. McKay, Karnyart Samnuan, Adrian Najer, Anna K. Blakney, Junyi Che, Gwen O'Driscoll, Martina Cihova, Molly M. Stevens, Robin J. Shattock   +9 more
wiley   +1 more source

Lassa Fever: Viral Replication, Disease Pathogenesis, and Host Immune Modulations

Pathogens, 2020
Despite major discoveries made in the last few decades about Lassa fever, there are still many unresolved key issues that hamper the development of effective vaccines and therapies against this deadly disease that is endemic in several West African ...
Hinh Ly
doaj   +1 more source

Characteristics of CD8+ and CD4+ Tissue‐Resident Memory Lymphocytes in the Gastrointestinal Tract

Advanced Gut &Microbiome Research, Volume 2022, Issue 1, 2022., 2022
Tissue‐resident memory T cells (TRMs) are plentiful in the memory T cell pool and persist in barrier sites without recirculating. Increasing evidence has shown that some kinds of CD8+ TRMs and CD4+ TRMs are resident in the gastrointestinal tract (GI), playing an important role in the context of microbiota‐immune interactions, infections, maintenance of
Pan Li, Yixi Zhang, Yanping Xu, Hongcui Cao, Lanjuan Li, Hang Xiao   +5 more
wiley   +1 more source

Use of Zoo Mice in Study of Lymphocytic Choriomeningitis Mammarenavirus, Germany

Emerging Infectious Diseases, 2023
Emerging Infectious Diseases. Roč. 30, č. 1 (2024), s. 205. ISSN 1080-6040. E-ISSN 1080-6059\n\nComment on Mehl, C., Wylezich, C., Geiger C., Schauerte, N., Mätz-Rensing, K., Nesseler, A., et al. Reemergence of lymphocytic choriomeningitis mammarenavirus, Germany. Emerg Infect Dis. 2023, 29:631–4.
Goüy de Bellocq, J. (Joëlle), Baird, Stuart J. E., Fornůsková, A. (Alena)   +2 more
openaire   +4 more sources

Lymphocytic Choriomeningitis Virus Infections and Seroprevalence, Southern Iraq

Emerging Infectious Diseases, 2020
Acute febrile neurological infection cases in southern Iraq (N = 212) were screened for lymphocytic choriomeningitis virus (LCMV). Two LCMV IgM–positive serum samples and 2 cerebrospinal fluid samples with phylogenetically distinct LCMV strains were ...
Hussein Alburkat, Anne J. Jääskeläinen, Ali M. Barakat, Hassan J. Hasony, Tarja Sironen, Haider Al-hello, Teemu Smura, Olli Vapalahti   +7 more
doaj   +1 more source

Observation of arenavirus nucleoprotein heptamer assembly

FEBS Open Bio, Volume 11, Issue 4, Page 1076-1083, April 2021., 2021
The nucleoprotein associates with RNA to form a ribonucleoprotein complex. The nucleoprotein trends to self‐assemble into heptameric rings. Theses rings represent stable intermediate states representative of the average full turn of the Arenaviridae ribonucleoprotein filament.
Nicolas Papageorgiou, Afroditi Vaitsopoulou, Awa Diop, Thi Hong Van Nguyen, Bruno Canard, Karine Alvarez, François Ferron   +6 more
wiley   +1 more source

Xapuri virus, a novel mammarenavirus: natural reassortment and increased diversity between New World viruses

Emerging Microbes and Infections, 2018
Mammarenavirus RNA was detected in Musser’s bristly mouse (Neacomys musseri) from the Amazon region, and this detection indicated that rodents were infected with a novel mammarenavirus, with the proposed name Xapuri virus (XAPV), which is ...
Jorlan Fernandes, Alexandro Guterres, Renata Carvalho de Oliveira, John Chamberlain, Kuiama Lewandowski, Bernardo Rodrigues Teixeira, Thayssa Alves Coelho, Charle Ferreira Crisóstomo, Cibele Rodrigues Bonvicino, Paulo Sérgio D’Andrea, Roger Hewson, Elba Regina Sampaio de Lemos   +11 more
doaj   +1 more source

Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro

Viruses, 2020
Mammarenaviruses cause chronic infections in rodents, which are their predominant natural hosts. Human infection with some of these viruses causes high-consequence disease, posing significant issues in public health.
Yu-Jin Kim, Beatrice Cubitt, Yingyun Cai, Jens H. Kuhn, Daniel Vitt, Hella Kohlhof, Juan C. de la Torre   +6 more
doaj   +1 more source

Host-Associated Distribution of Two Novel Mammarenaviruses in Rodents from Southern Africa

Viruses, 2022
Mammarenaviruses are hosted by several rodent species, a small number of which have been known to be zoonotic. Host surveillance among small mammals has identified a large diversity of previously undescribed mammarenaviruses.
Marike Geldenhuys, Jacqueline Weyer, Teresa Kearney, Wanda Markotter   +3 more
doaj   +1 more source