Results 41 to 50 of about 12,650 (152)

A novel mammarenavirus (family Arenaviridae) in hedgehogs (Erinaceus roumanicus) in Europe

Archives of Virology, 2023
AbstractIn this study, a novel mammarenavirus (family Arenaviridae) was identified in a hedgehog (family Erinaceidae) in Hungary and genetically characterized. Mecsek Mountains virus (MEMV, OP191655, OP191656) was detected in nine (45%) out of 20 faecal specimens collected from a Northern white-breasted hedgehog (Erinaceus roumanicus).
Gábor Reuter, Ákos Boros, Károly Takáts, Róbert Mátics, Péter Pankovics   +4 more
openaire   +2 more sources

Surveillance of Zoonotic Pathogens in Small Mammals Across Forests With Different Levels of Anthropization in Eastern France. [PDF]

Transbound Emerg Dis
The emergence of infectious diseases associated with land‐use changes is well‐documented. However, the presence and dynamics of zoonotic pathogens in small mammals within European forests, whether from rural development or urban greening, remain underexplored.
Bouilloud M, Galan M, Bordes A, Tatard C, Gauthier P, Pradel J, Castel G, Alburkat H, Dutra L, Sironen T, Galon C, Moutailler S, Djelouadji Z, Roche B, Charbonnel N.   +14 more
europepmc   +2 more sources

Complete Genome Sequence of a Novel Variant of Wenzhou Mammarenavirus [PDF]

Genome Announcements, 2017
ABSTRACT Wenzhou mammarenavirus (WENV) is a novel species of Arenavirus that was first detected in China. We report here a novel WENV variant (WENV G107) from liver samples of Rattus norvegicus that shares 84.7% to 86.8% (large [L] segment) and 84.2% to 87.8% (small [S] segment ...
Liu, Meng-meng, Li, Li-li, Wang, Xiao-feng, Duan, Zhao-jun   +3 more
openaire   +2 more sources

Proteomics Computational Analyses Suggest that the Antennavirus Glycoprotein Complex Includes a Class I Viral Fusion Protein (α-Penetrene) with an Internal Zinc-Binding Domain and a Stable Signal Peptide

Viruses, 2019
A metatranscriptomic study of RNA viruses in cold-blooded vertebrates identified two related viruses from frogfish (Antennarius striatus) that represent a new genus Antennavirus in the family Arenaviridae (Order: Bunyavirales).
Courtney E. Garry, Robert F. Garry
doaj   +1 more source

Screening and Identification of Lujo Virus Entry Inhibitors From an Food and Drug Administration-Approved Drugs Library

Frontiers in Microbiology, 2021
Lujo virus (LUJV) belongs to the Old World (OW) genus Mammarenavirus (family Arenaviridae). It is categorized as a biosafety level (BSL) 4 agent. Currently, there are no U.S.
Junyuan Cao, Junyuan Cao, Siqi Dong, Siqi Dong, Yang Liu, Minmin Zhou, Minmin Zhou, Jiao Guo, Jiao Guo, Xiaoying Jia, Xiaoying Jia, Yueli Zhang, Yueli Zhang, Yuxia Hou, Yuxia Hou, Ming Tian, Gengfu Xiao, Gengfu Xiao, Wei Wang, Wei Wang   +19 more
doaj   +1 more source

Understanding Immune Responses to Lassa Virus Infection and to Its Candidate Vaccines

Vaccines, 2022
Lassa fever (LF) is a deadly viral hemorrhagic fever disease that is endemic in several countries in West Africa. It is caused by Lassa virus (LASV), which has been estimated to be responsible for approximately 300,000 infections and 5000 deaths annually.
Hannah Murphy, Hinh Ly
doaj   +1 more source

Type I interferon underlies severe disease associated with Junín virus infection in mice

eLife, 2020
Junín virus (JUNV) is one of five New World mammarenaviruses (NWMs) that causes fatal hemorrhagic disease in humans and is the etiological agent of Argentine hemorrhagic fever (AHF).
Brady T Hickerson, Eric J Sefing, Kevin W Bailey, Arnaud J Van Wettere, Manuel L Penichet, Brian B Gowen   +5 more
doaj   +1 more source

Recombinant Lassa Virus Expressing Green Fluorescent Protein as a Tool for High-Throughput Drug Screens and Neutralizing Antibody Assays

Viruses, 2018
Lassa virus (LASV), a mammarenavirus, infects an estimated 100,000⁻300,000 individuals yearly in western Africa and frequently causes lethal disease.
Yíngyún Caì, Masaharu Iwasaki, Brett F. Beitzel, Shuīqìng Yú, Elena N. Postnikova, Beatrice Cubitt, Lisa Evans DeWald, Sheli R. Radoshitzky, Laura Bollinger, Peter B. Jahrling, Gustavo F. Palacios, Juan C. de la Torre, Jens H. Kuhn   +12 more
doaj   +1 more source

RIG-I and MDA5 Protect Mice From Pichinde Virus Infection by Controlling Viral Replication and Regulating Immune Responses to the Infection

Frontiers in Immunology, 2021
RIG-I and MDA5 are major cytoplasmic innate-immune sensor proteins that recognize aberrant double-stranded RNAs generated during virus infection to activate type 1 interferon (IFN-I) and IFN-stimulated gene (ISG) expressions to control virus infection ...
Morgan Brisse, Morgan Brisse, Qinfeng Huang, Mizanur Rahman, Da Di, Yuying Liang, Hinh Ly, Hinh Ly   +7 more
doaj   +1 more source

Reverse genetics approaches for the development of mammarenavirus live-attenuated vaccines

Current Opinion in Virology, 2020
Several mammarenaviruses can cause severe hemorrhagic fever disease with a very high case fatality rate, representing important threats to human health within the viruses' endemic regions. To date, there are no United States (US) Food and Drug Administration (FDA)-licensed vaccines available to combat mammarenavirus infections in humans, and current ...
Chengjin, Ye, Juan C, de la Torre, Luis, Martinez-Sobrido   +2 more
openaire   +3 more sources