Results 61 to 70 of about 12,650 (152)

The Study of Viral RNA Diversity in Bird Samples Using De Novo Designed Multiplex Genus‐Specific Primer Panels

Advances in Virology, Volume 2018, Issue 1, 2018., 2018
Advances in the next generation sequencing (NGS) technologies have significantly increased our ability to detect new viral pathogens and systematically determine the spectrum of viruses prevalent in various biological samples. In addition, this approach has also helped in establishing the associations of viromes with many diseases.
Andrey A. Ayginin, Ekaterina V. Pimkina, Alina D. Matsvay, Anna S. Speranskaya, Marina V. Safonova, Ekaterina A. Blinova, Ilya V. Artyushin, Vladimir G. Dedkov, German A. Shipulin, Kamil Khafizov, Gary S. Hayward   +10 more
wiley   +1 more source

Highly Diverse Arenaviruses in Neotropical Bats, Brazil

Emerging Infectious Diseases, 2022
We detected arenavirus RNA in 1.6% of 1,047 bats in Brazil that were sampled during 2007–2011. We identified Tacaribe virus in 2 Artibeus sp. bats and a new arenavirus species in Carollia perspicillata bats that we named Tietê mammarenavirus.
Luiz Gustavo Bentim Góes, Carlo Fischer, Angélica Cristine Almeida Campos, Cristiano de Carvalho, Andrés Moreira-Soto, Guilherme Ambar, Adriana Ruckert da Rosa, Debora Cardoso de Oliveira, Wendy Karen Jo, Ariovaldo P. Cruz-Neto, Wagner André Pedro, Luzia Helena Queiroz, Paola Minoprio, Edison L. Durigon, Jan Felix Drexler   +14 more
doaj   +1 more source

Virulent infection of outbred Hartley guinea pigs with recombinant Pichinde virus as a surrogate small animal model for human Lassa fever

Virulence, 2020
Arenaviruses, such as Lassa virus (LASV), can cause severe and fatal hemorrhagic fevers (e.g., Lassa fever, LF) in humans with no vaccines or therapeutics.
Shuiyun Lan, Wun-Ju Shieh, Qinfeng Huang, Sherif R. Zaki, Yuying Liang, Hinh Ly   +5 more
doaj   +1 more source

Partitioning Social and Spatial Drivers of Infection Risk

Ecology and Evolution, Volume 15, Issue 11, November 2025.
Contact rates drive disease spread, yet are often oversimplified as uniform across individuals. Using data on Mastomys natalensis, we show that exposure to Morogoro virus is linked to spatial overlap with infected conspecifics, but not overall overlap, and that direct contact occurs with only a few individuals despite broad home range overlap ...
L. Kirkpatrick, J. Mariën, C. Sabuni, B. Mwamundela, H. Leirs   +4 more
wiley   +1 more source

Multifunctional noncoding regions in the mammarenavirus genome

Virology
Mammarenaviruses often cause long-term asymptomatic chronic infections in their natural hosts, primarily rodents, and include several human pathogens responsible for diseases ranging from mild febrile illnesses to life-threatening hemorrhagic fever.
openaire   +3 more sources

Disease X Testing: The results of an international external quality assessment exercise

Journal of Biosafety and Biosecurity, 2022
The United Nations Secretary-General Mechanism (UNSGM) for investigation of the alleged use of chemical and biological weapons is the only established international mechanism of this type under the UN. The UNGSM may launch an international investigation,
Tian Qin, Han Zheng, Xuelian Luo, Wen Zhang, Jing Yang, Yamin Sun, Na Han, Yuanhai You, Liang Lu, Xin Lu, Di Xiao, Shenshen Jiang, Xuexin Hou, Jinxing Lu, Biao Kan, Jianzhong Zhang, Jianguo Xu   +16 more
doaj   +1 more source

Ecologic Traits Analysis for Identifying Rodent Hosts for Arenavirus and Hepacivirus in the Americas

Biotropica, Volume 57, Issue 6, November 2025.
Over half of emerging human pathogens originate from wildlife, with rodents serving as key zoonotic hosts. This study used ecological trait‐based models to identify rodent traits associated with arenavirus and hepacivirus infections and detect potential host species across the Americas, our models achieve high predictive accuracy (AUC = 0.92–0.96).
María del Carmen Villalobos‐Segura, Oscar Rico‐Chavéz, Gerardo Suzán, Andrea Chaves   +3 more
wiley   +1 more source

A Mutation‐Based Reverse Vaccinology Approach Considering Variability in Epitopes to Combat Multi‐Strains: A Study Using Glycoprotein of LASV

Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT Lassa virus (LASV) remains a persistent threat to public health, and to combat this, various therapeutics have been developed, but their effectiveness is limited due to the virus's strain variability. Therefore, mutation‐based reverse vaccinology approaches were implemented to formulate an epitope‐based vaccine against the LASV, considering ...
Saurav Kumar Mishra, Rajesh B. Patil, Amdola Tshering Sherpa, Mohammad Borhan Uddin, Md. Harun‐Or‐Rashid, Muniruddin Ahmed, Turki M. Dawoud, John J. Georrge   +7 more
wiley   +1 more source

Unraveling the Mechanistic Links Between Species Diversity and Infection Risk From Zoonotic Pathogens With Direct Transmission Among Reservoir Hosts: Rodent‐Orthohantavirus Systems as Models

Ecology and Evolution, Volume 15, Issue 6, June 2025.
In this review, we synthesize mechanistic evidence for diversity‐disease patterns in rodent‐orthohantavirus systems in the Americas, models of directly transmitted disease systems. We found that host regulation has been examined the most while other mechanisms have received less attention. Based on our findings, we propose that for a negative diversity‐
Andreas Eleftheriou, Angela D. Luis
wiley   +1 more source

Land Use Change and Infectious Disease Emergence

Reviews of Geophysics, Volume 63, Issue 2, June 2025.
Abstract Major infectious diseases threatening human health are transmitted to people from animals or by arthropod vectors such as insects. In recent decades, disease outbreaks have become more common, especially in tropical regions, including new and emerging infections that were previously undetected or unknown. Even though there is growing awareness
M. Cristina Rulli, Paolo D’Odorico, Nikolas Galli, Reju S. John, Renata L. Muylaert, Monia Santini, David T. S. Hayman   +6 more
wiley   +1 more source