Results 61 to 70 of about 12,732 (162)

Genome Sequence of Serodino virus, a novel Oliveros-like Clade C Mammarenavirus

, 2023
A novel Mammarenavirus genome was identified within a suspect hantavirus sample collected from a rodent in Maciel, Argentina. Metagenomic deep sequencing analysis revealed Mammarenavirus-like reads in addition to those belonging to a species of ...
Klena, John, Shedroff, Elizabeth, Montgomery, Joel, Whitmer, Shannon   +3 more
core   +1 more source

Screening and Identification of Lujo Virus Entry Inhibitors From an Food and Drug Administration-Approved Drugs Library

Frontiers in Microbiology, 2021
Lujo virus (LUJV) belongs to the Old World (OW) genus Mammarenavirus (family Arenaviridae). It is categorized as a biosafety level (BSL) 4 agent. Currently, there are no U.S.
Junyuan Cao, Junyuan Cao, Siqi Dong, Siqi Dong, Yang Liu, Minmin Zhou, Minmin Zhou, Jiao Guo, Jiao Guo, Xiaoying Jia, Xiaoying Jia, Yueli Zhang, Yueli Zhang, Yuxia Hou, Yuxia Hou, Ming Tian, Gengfu Xiao, Gengfu Xiao, Wei Wang, Wei Wang   +19 more
doaj   +1 more source

Understanding Immune Responses to Lassa Virus Infection and to Its Candidate Vaccines

Vaccines, 2022
Lassa fever (LF) is a deadly viral hemorrhagic fever disease that is endemic in several countries in West Africa. It is caused by Lassa virus (LASV), which has been estimated to be responsible for approximately 300,000 infections and 5000 deaths annually.
Hannah Murphy, Hinh Ly
doaj   +1 more source

Type I interferon underlies severe disease associated with Junín virus infection in mice

eLife, 2020
Junín virus (JUNV) is one of five New World mammarenaviruses (NWMs) that causes fatal hemorrhagic disease in humans and is the etiological agent of Argentine hemorrhagic fever (AHF).
Brady T Hickerson, Eric J Sefing, Kevin W Bailey, Arnaud J Van Wettere, Manuel L Penichet, Brian B Gowen   +5 more
doaj   +1 more source

RIG-I and MDA5 Protect Mice From Pichinde Virus Infection by Controlling Viral Replication and Regulating Immune Responses to the Infection

Frontiers in Immunology, 2021
RIG-I and MDA5 are major cytoplasmic innate-immune sensor proteins that recognize aberrant double-stranded RNAs generated during virus infection to activate type 1 interferon (IFN-I) and IFN-stimulated gene (ISG) expressions to control virus infection ...
Morgan Brisse, Morgan Brisse, Qinfeng Huang, Mizanur Rahman, Da Di, Yuying Liang, Hinh Ly, Hinh Ly   +7 more
doaj   +1 more source

The most recent common ancestor (MRCA) stratified by host and country of collection of Lassa mammarenavirus (LASV) S and L segments.

, 2023
The most recent common ancestor (MRCA) stratified by host and country of collection of Lassa mammarenavirus (LASV) S and L segments.
Hayley Beth Free (17357108), Rashid Ansumana (586899), Danny Asogun (11462500), David Simons (173163), Richard Kock (377453), Linzy Elton (9750221), Najmul Haider (2580235), Liã Bárbara Arruda (12573077), Francine Ntoumi (573318), Alimuddin Zumla (65389), Timothy D. McHugh (372721), Isobella Honeyborne (1624234)   +11 more
core   +1 more source

Recombinant Lassa Virus Expressing Green Fluorescent Protein as a Tool for High-Throughput Drug Screens and Neutralizing Antibody Assays

Viruses, 2018
Lassa virus (LASV), a mammarenavirus, infects an estimated 100,000⁻300,000 individuals yearly in western Africa and frequently causes lethal disease.
Yíngyún Caì, Masaharu Iwasaki, Brett F. Beitzel, Shuīqìng Yú, Elena N. Postnikova, Beatrice Cubitt, Lisa Evans DeWald, Sheli R. Radoshitzky, Laura Bollinger, Peter B. Jahrling, Gustavo F. Palacios, Juan C. de la Torre, Jens H. Kuhn   +12 more
doaj   +1 more source

Reverse genetics approaches for the development of mammarenavirus live-attenuated vaccines

Current Opinion in Virology, 2020
Several mammarenaviruses can cause severe hemorrhagic fever disease with a very high case fatality rate, representing important threats to human health within the viruses' endemic regions. To date, there are no United States (US) Food and Drug Administration (FDA)-licensed vaccines available to combat mammarenavirus infections in humans, and current ...
Chengjin, Ye, Juan C, de la Torre, Luis, Martinez-Sobrido   +2 more
openaire   +3 more sources

Hearing loss in outbred Hartley guinea pigs experimentally infected with Pichinde virus as a surrogate model of human mammarenaviral hemorrhagic fevers

Virulence, 2022
Lassa fever (LF) is a neglected tropical disease that is caused by Lassa virus (LASV), a human hemorrhagic fever-causing mammarenavirus. A notable sequela of LF is sensorineural hearing loss (SNHL) that can develop in about 33% of the patients.
Morgan Brisse, Claudia Fernández-Alarcón, Qinfeng Huang, Natalie Kirk, Mark R. Schleiss, Yuying Liang, Hinh Ly   +6 more
doaj   +1 more source

Dhati Welel virus, the missing mammarenavirus of the widespread Mastomys natalensis [PDF]

Journal of Vertebrate Biology, 2020
The Natal multimammate mouse, Mastomys natalensis, occurs throughout sub-Saharan Africa. Mitochondrial phylogenetics indicate this species was fragmented during the Pleistocene, forming six matrilineage phylogroups: A-I, A-II, A-III, B-IV, B-V, B-VI with distinct ranges.
Goüy de Bellocq, J. (Joëlle), Bryjová, A. (Anna), Martynov, A. A., Lavrenchenko, L. A.   +3 more
openaire   +2 more sources