Results 51 to 60 of about 12,650 (152)

Hearing loss in outbred Hartley guinea pigs experimentally infected with Pichinde virus as a surrogate model of human mammarenaviral hemorrhagic fevers

Virulence, 2022
Lassa fever (LF) is a neglected tropical disease that is caused by Lassa virus (LASV), a human hemorrhagic fever-causing mammarenavirus. A notable sequela of LF is sensorineural hearing loss (SNHL) that can develop in about 33% of the patients.
Morgan Brisse, Claudia Fernández-Alarcón, Qinfeng Huang, Natalie Kirk, Mark R. Schleiss, Yuying Liang, Hinh Ly   +6 more
doaj   +1 more source

A novel circulating tamiami mammarenavirus shows potential for zoonotic spillover

PLOS Neglected Tropical Diseases, 2020
A detailed understanding of the mechanisms underlying the capacity of a virus to break the species barrier is crucial for pathogen surveillance and control. New World (NW) mammarenaviruses constitute a diverse group of rodent-borne pathogens that includes several causative agents of severe viral hemorrhagic fever in humans.
Moreno, Hector, Rastrojo, Alberto, Pryce, Rhys, Fedeli, Chiara, Zimmer, Gert, Bowden, Thomas A, Gerold, Gisa, Kunz, Stefan   +7 more
openaire   +9 more sources

Combination of highly antigenic nucleoproteins to inaugurate a cross-reactive next generation vaccine candidate against Arenaviridae family

Heliyon, 2021
Arenaviral infections often result lethal hemorrhagic fevers, affecting primarily in African and South American regions. To date, there is no FDA-approved licensed vaccine against arenaviruses and treatments have been limited to supportive therapy. Hence,
Kazi Faizul Azim, Tahera Lasker, Rahima Akter, Mantasha Mahmud Hia, Omar Faruk Bhuiyan, Mahmudul Hasan, Md Nazmul Hossain   +6 more
doaj   +1 more source

Land use gradients drive spatial variation in Lassa fever host communities in the Eastern Province of Sierra Leone

Journal of Animal Ecology, Volume 95, Issue 2, Page 296-312, February 2026.
As West Africa urbanises, the risk of Lassa fever may paradoxically decrease. We found the invasive house mouse, a dominant urban species, outcompetes and displaces the primary Lassa virus host. Considering these species interactions is critical for accurately predicting future zoonotic disease patterns.
David Simons, Rory Gibb, Umaru Bangura, Dianah Sondufu, Joyce Lamin, James Koninga, Momoh Foday, Mike Dawson, Joseph Lahai, Rashid Ansumana, Elisabeth Fichet‐Calvet, Deborah Watson‐Jones, Richard Kock, Kate E. Jones   +13 more
wiley   +1 more source

Chapare mammarenavirus - a new deadly virus outbreak: a review

International Journal of Research in Medical Sciences, 2020
In 2003 an emerging mammarenavirus (formerly arenaviruses) was discovered in Bolivia and named Chapare (CHAPV). It was related to severe and fatal haemorrhagic fever, being similar in clinical features to Machupo (MACV). In mid-2019, CHAPV was the explanation for a cluster of 5 cases, two of them laboratory confirmed, three of them fatal.
Dnyaneshwari Gujar, N. Sriram Choudary, Chaitrali Joshi, Nikhitha Raigir, Shreshth Sharma, Kommuri Baji Babu, Rahul V. C. Tiwari   +6 more
openaire   +2 more sources

Dhati Welel virus, the missing mammarenavirus of the widespread Mastomys natalensis [PDF]

Journal of Vertebrate Biology, 2020
The Natal multimammate mouse, Mastomys natalensis, occurs throughout sub-Saharan Africa. Mitochondrial phylogenetics indicate this species was fragmented during the Pleistocene, forming six matrilineage phylogroups: A-I, A-II, A-III, B-IV, B-V, B-VI with distinct ranges.
Goüy de Bellocq, J. (Joëlle), Bryjová, A. (Anna), Martynov, A. A., Lavrenchenko, L. A.   +3 more
openaire   +2 more sources

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Complete Genome Sequence of a Mammarenavirus Harbored by Rodents on Hainan Island, China [PDF]

Genome Announcements, 2018
ABSTRACT Wenzhou virus (WENV) is a rodent-borne mammarenavirus that was recently found to infect humans. In this study, we sequenced and analyzed the complete genome of a genetic variant of WENV, HMU (Hainan Medical University) virus.
Zhang, You, Rao, Langyu, Lv, Gang, Zhang, Lei, Fu, Ruijia, Wang, Shanshan, Wu, Yue, Cui, Xiuji, Yin, Feifei   +8 more
openaire   +2 more sources

Pichinde Virus Infection of Outbred Hartley Guinea Pigs as a Surrogate Animal Model for Human Lassa Fever: Histopathological and Immunohistochemical Analyses

Pathogens, 2020
Lassa virus (LASV) is a mammarenavirus (arenavirus) that causes zoonotic infection in humans that can lead to fatal hemorrhagic Lassa fever (LF) disease. Currently, there are no FDA-approved vaccines or therapeutics against LASV.
Wun-Ju Shieh, Shuiyun Lan, Sherif R. Zaki, Hinh Ly, Yuying Liang   +4 more
doaj   +1 more source

Research Output and Global Trends in Lassa Fever: A 50‐Year Bibliometric Analysis (1975–2025)

BioMed Research International, Volume 2026, Issue 1, 2026.
Background Lassa fever poses a significant public health threat, primarily concentrated in West Africa. This bibliometric study aimed to document research outputs concerning Lassa fever. It analyzes trends in research publication output, the participation of various countries, productive institutions and their collaboration networks, influential ...
Ifeanyi Ferdinand Chukwuma, Chioma Miracle Ojiako, Simon Pierre Yinyang Danga, Kenechukwu David Oli, Ruth Asikiya Afunwa, Angus Nnamdi Oli, Poorani Gurumallesh Prabu   +6 more
wiley   +1 more source