PLoS Pathogens, 2021 Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including New World and Old ...
Nicolás Sarute +6 more
doaj +1 more source
Z Proteins of New World Arenaviruses Bind RIG-I and Interfere with Type I Interferon Induction [PDF]
Journal of Virology, 2009 ABSTRACT The retinoic acid-inducible gene I product (RIG-I) is a cellular sensor of RNA virus infection that regulates the cellular beta interferon (IFN-β) response. The nucleoproteins (NP) of arenaviruses are reported to antagonize the IFN response by inhibiting interferon regulatory factor 3 (IRF-3). Here, we demonstrate that the Z proteins
L. Fan, T. Briese, W. Lipkin
semanticscholar +3 more sources
The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers
Проблемы особо опасных инфекций, 2018 Presently, the Arenavirus genus (Arenaviridae family) includes 26 individual species of viruses. It is divided into two main groups – Old World arenaviruses and New World arenaviruses.
T. E. Sizikova +3 more
doaj +1 more source
Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia. [PDF]
PLoS Pathogens, 2008 A small focus of hemorrhagic fever (HF) cases occurred near Cochabamba, Bolivia, in December 2003 and January 2004. Specimens were available from only one fatal case, which had a clinical course that included fever, headache, arthralgia, myalgia, and ...
Simon Delgado +11 more
doaj +1 more source
An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses [PDF]
Journal of Virology, 2012 ABSTRACT Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells by binding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1.
G. Helguera +11 more
semanticscholar +4 more sources
DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection.
PLoS Pathogens, 2018 Several arenaviruses cause hemorrhagic fever (HF) diseases that are associated with high morbidity and mortality in humans. Accordingly, HF arenaviruses have been listed as top-priority emerging diseases for which countermeasures are urgently needed ...
María Eugenia Loureiro +15 more
doaj +1 more source
Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses
Vaccines, 2019 The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo +2 more
doaj +1 more source
The board is set, the pieces are moving: Modulation of New World arenavirus entry by host proteins
PLoS Pathogens, 2021 Arenaviruses are enveloped viruses with 2 ambisense genomic RNA molecules, whose entry into cells is mediated by the viral glycoprotein (GP), generated by proteolytic processing of the precursor GPC into the subunits GP1 (the receptor-binding domain ...
Nicolás Sarute, S. Ross
semanticscholar +1 more source
Single Nucleoprotein Residue Modulates Arenavirus Replication Complex Formation
mBio, 2015 The Arenaviridae are enveloped, negative-sense RNA viruses with several family members that cause hemorrhagic fevers. This work provides immunofluorescence evidence that, unlike those of New World arenaviruses, the replication and transcription complexes
Kristeene A. Knopp +3 more
doaj +1 more source
Sabiá Virus–Like Mammarenavirus in Patient with Fatal Hemorrhagic Fever, Brazil, 2020
Emerging Infectious Diseases, 2020 New World arenaviruses can cause chronic infection in rodents and hemorrhagic fever in humans. We identified a Sabiá virus–like mammarenavirus in a patient with fatal hemorrhagic fever from São Paulo, Brazil.
Fernanda de Mello Malta +13 more
doaj +1 more source