Results 1 to 10 of about 65,972 (187)

Methylglyoxal-Modified Albumin Effects on Endothelial Arginase Enzyme and Vascular Function

Cells, 2023
Advanced glycation end products (AGEs) contribute significantly to vascular dysfunction (VD) in diabetes. Decreased nitric oxide (NO) is a hallmark in VD. In endothelial cells, NO is produced by endothelial NO synthase (eNOS) from L-arginine.
Ebaa M. Alzayadneh, Alia Shatanawi, R. William Caldwell, Ruth B. Caldwell   +3 more
doaj   +1 more source

Impact of suitable control on a uniform interpretation of units for arginase assay

Biochemistry and Biophysics Reports, 2021
The arginase catalyzes the conversion of arginine into ornithine and urea. The activity of arginase serves as a critical diagnostic marker for several pathophysiological conditions.
Mishra Suman, Mishra Rajnikant
doaj   +1 more source

Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets. [PDF]

PLoS ONE, 2010
Increased catabolism of arginine by arginase is increasingly viewed as an important pathophysiological factor in cardiovascular disease, including atherosclerosis induced by high cholesterol diets.
Aaron Erdely, Diane Kepka-Lenhart, Rebecca Salmen-Muniz, Rebecca Chapman, Tracy Hulderman, Michael Kashon, Petia P Simeonova, Sidney M Morris   +7 more
doaj   +1 more source

Enhancing the Production of Therapeutic Enzyme Arginase from Lactobacillus acidophilus Using Response Surface Methodology

Brazilian Archives of Biology and Technology, 2022
Arginase plays an imperative role in the cell growth and proliferation of healthy cells under normal physiological conditions. Recently arginase has gained the sight of many researchers as it has emerged as a potential candidate for auxotrophic cancer ...
Himanshi Gautam, Neha Kumari, Saurabh Bansal   +2 more
doaj   +1 more source

Arginase: shedding light on the mechanisms and opportunities in cardiovascular diseases

Cell Death Discovery, 2022
Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform significant roles in the regulation of cellular functions in cardiovascular system,
Zhuozhuo Li, Liwei Wang, Yuanyuan Ren, Yaoyao Huang, Wenxuan Liu, Ziwei Lv, Lu Qian, Yi Yu, Yuyan Xiong   +8 more
doaj   +1 more source

Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production. [PDF]

PLoS ONE, 2012
Consumption of L-arginine contributes to reduced bioavailability of nitric oxide (NO) that is critical for the development of ischemia-reperfusion injury.
Adrian T Gonon, Christian Jung, Abram Katz, Håkan Westerblad, Alexey Shemyakin, Per-Ove Sjöquist, Jon O Lundberg, John Pernow   +7 more
doaj   +1 more source

Inhibition of Arginase 1 Liberates Potent T Cell Immunostimulatory Activity of Human Neutrophil Granulocytes

Frontiers in Immunology, 2021
Myeloid cell arginase-mediated arginine depletion with consecutive inhibition of T cell functions is a key component of tumor immune escape. Both, granulocytic myeloid-derived suppressor cells (G-MDSC) and conventional mature human polymorphonuclear ...
Verena Vonwirth, Yagmur Bülbül, Anke Werner, Hakim Echchannaoui, Hakim Echchannaoui, Johannes Windschmitt, Alice Habermeier, Sonia Ioannidis, Niu Shin, Roland Conradi, Matthias Bros, Stefan Tenzer, Matthias Theobald, Matthias Theobald, Matthias Theobald, Ellen Ildicho Closs, Markus Munder, Markus Munder   +17 more
doaj   +1 more source

Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice

BMC Immunology, 2009
Background Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not been fully elucidated in mice.
Rothenberg Marc E, Wills-Karp Marsha, O'Brien William E, Cederbaum Stephen D, Hajek Amanda R, Collier Ann R, Niese Kathryn A, Zimmermann Nives   +7 more
doaj   +1 more source

Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo

Molecular Therapy: Methods & Clinical Development, 2020
Arginase is a complex and unique enzyme that plays diverse roles in health and disease. By metabolizing arginine, it can shape the outcome of innate and adaptive immune responses. The immunomodulatory capabilities of arginase could potentially be applied
Makan Khoshnejad, Alfredo Perales-Puchalt, Yaya Dia, Peng Xiao, Ami Patel, Ziyang Xu, Xizhou Zhu, Kun Yun, Ishana Baboo, Rehman Qureshi, Laurent Humeau, Kar Muthumani, David B. Weiner   +12 more
doaj   +1 more source

The Effect of Arginase on Canine T-Lymphocyte Functions and its Modulation by All-Trans Retinoid Acid (ATRA) in Canine Monocyte-Derived Macrophages

Veterinary Sciences, 2022
Immunosuppressive myeloid cells in the tumor microenvironment play a major role in suppressing tumor immunity via the production of arginase, IL-10, and others.
Aimee M. Soileau, Cally N. Quick, Cambri E. Moeller, Jessica C. Schaumburg, Sita S. Withers   +4 more
doaj   +1 more source