Results 21 to 30 of about 65,972 (187)
Role of Arginase 2 as a potential pharmacological target for the creation of new drugs to correct cardiovascular diseases [PDF]
Research Results in Pharmacology, 2020 Introduction: The review provides relevant information about arginase 2, the role of this enzyme in the formation of endothelial dysfunction and, as a consequence, the development of cardiovascular diseases.
Sergey A. Demchenko +2 more
doaj +3 more sources
Progress in Retinal and Eye Research, 2013 Ischemic retinopathies, such as diabetic retinopathy (DR), retinopathy of prematurity and retinal vein occlusion are a major cause of blindness in developed nations worldwide. Each of these conditions is associated with early neurovascular dysfunction.
S Priya, Narayanan +5 more
openaire +2 more sources
Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease [PDF]
, 2018 The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin on the substantia nigra (SN),
Boza-Serrano, Antonio, +11 more
core +1 more source
Scientifica, 2016 Arginase regulates arginine metabolism, ornithine-urea cycle, and immunological surveillance. Arginase-I is predominant in cytosol, and arginase-II is localised in the mitochondria.
Mishra Suman, Mishra Rajnikant
doaj +1 more source
POLARIZED ACTIVATION OF HUMAN PERIPHERAL BLOOD PHAGOCYTES BY BACTERIOPHAGE–DERIVED DOUBLE-STRANDED RNA (LARIFAN) IN VITRO [PDF]
Biotechnologia Acta, 2023 Aim. This study aimed to examine the effect of Larifan on metabolic characteristics of human blood monocytes and granulocytes in vitro. Methods. Four healthy adult men aged 21-26 years were recruited to participate in the study as blood donors.
R. Dovhyi +8 more
doaj +1 more source
Frequent adaptive immune responses against arginase-1
OncoImmunology, 2018 The enzyme arginase-1 reduces the availability of arginine to tumor-infiltrating immune cells, thus reducing T-cell functionality in the tumor milieu. Arginase-1 is expressed by some cancer cells and by immune inhibitory cells, such as myeloid-derived ...
Evelina Martinenaite +9 more
doaj +1 more source
Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart [PDF]
, 2014 This is the final version. It was first published by Wiley in The Journal of Physiology at http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2014.275263/abstract.Hypoxic exposure is associated with impaired cardiac energetics in humans and altered ...
Andrew J. Murray +11 more
core +2 more sources
Evaluation of optimal conditions for arginase activity in streptozotocin induced diabetic rats
Veterinární Medicína, 2005 The assay conditions needed to achieve maximal activity of liver and kidney arginase in diabetic and non-diabetic rats were investigated and compared.
M. Erisir, E. Ercel, S. Yilmaz, S. Ozan
doaj +1 more source
Molecular Genetics and Metabolism Reports, 2021 Arginase deficiency is a rare inborn error of metabolism that interrupts the final step of the urea cycle. Untreated individuals often present with episodic hyperammonemia, developmental delay, cognitive impairment, and spasticity in early childhood. The
Yue Huang +14 more
doaj +1 more source
Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice [PDF]
, 2019 We investigated the contribution of human platelets to macrophage effector properties in the presence of lipopolysaccharide (LPS), as well as the beneficial effects and time frame for platelet transfusion in septic animals.
Carestia, Agostina +9 more
core +1 more source