Results 21 to 30 of about 78,666 (255)

Arginase-1 targeting peptide vaccine in patients with metastatic solid tumors – A phase I trial

Frontiers in Immunology, 2022
Background Arginase-1-producing cells inhibit T cell-mediated anti-tumor responses by reducing L-arginine levels in the tumor microenvironment. T cell-facilitated elimination of arginase-1-expressing cells could potentially restore L-arginine levels and ...
C. Lorentzen, E. Martinenaite, J. Kjeldsen, R. Holmstroem, Sofie Kirial Mørk, A. Pedersen, E. Ehrnrooth, M. Andersen, I. Svane   +8 more
semanticscholar   +1 more source

Visceral leishmaniasis patients display altered composition and maturity of neutrophils as well as impaired neutrophil effector functions [PDF]

, 2016
Immunologically, active visceral leishmaniasis (VL) is characterised by profound immunosuppression, severe systemic inflammatory responses and an impaired capacity to control parasite replication.
Adem, E, Cruz Cervera, E, Diro, E, Getahun, M, Hailu, A, Kropf, P, Lemma, M, Melkamu, R, Mengesha, B, Mesfin, G, Modolell, M, Muller, I, Munder, M, Skhedy, Z, Tajebe, F, Takele, Y, Van der Auwera, G, Yardley, V, Yeshanew, A, Yizengaw, E   +19 more
core   +6 more sources

Arginase from kiwifruit: properties and seasonal variation [PDF]

, 1988
The in vitro activity of arginase (EC 3.5.3.1) was investigated in youngest-mature leaves and roots (1-3 mm diameter) of kiwifruit vines (Actinidia deliciosa var. deliciosa) during an annual growth cycle, and enzyme from root material partially purified.
Dwek, RA, Fellows, LE, Fleet, GW, Karpas, A, Namgoong, SK, Petursson, S, Ramsden, NG, Smith, PW, Son, JC, Tyms, AS   +9 more
core   +4 more sources

Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma

Oncoimmunology, 2021
Immunotherapy has demonstrated significant activity in a broad range of cancer types, but still the majority of patients receiving it do not maintain durable therapeutic responses.
A. Sosnowska, Justyna Chlebowska-Tuz, Paweł Matryba, Z. Pilch, A. Greig, Artur Wolny, T. Grzywa, Z. Rydzyńska, Olga Sokolowska, T. Rygiel, Marcin Grzybowski, P. Stanczak, R. Błaszczyk, D. Nowis, J. Gołąb   +14 more
semanticscholar   +1 more source

Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production. [PDF]

PLoS ONE, 2012
Consumption of L-arginine contributes to reduced bioavailability of nitric oxide (NO) that is critical for the development of ischemia-reperfusion injury.
Adrian T Gonon, Christian Jung, Abram Katz, Håkan Westerblad, Alexey Shemyakin, Per-Ove Sjöquist, Jon O Lundberg, John Pernow   +7 more
doaj   +1 more source

Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release

Scientific Reports, 2021
Human neutrophils constitutively express high amounts of arginase-1, which depletes arginine from the surrounding medium and downregulates T-cell activation.
R. García-Navas, C. Gajate, F. Mollinedo   +2 more
semanticscholar   +1 more source

Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice

BMC Immunology, 2009
Background Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not been fully elucidated in mice.
Rothenberg Marc E, Wills-Karp Marsha, O'Brien William E, Cederbaum Stephen D, Hajek Amanda R, Collier Ann R, Niese Kathryn A, Zimmermann Nives   +7 more
doaj   +1 more source

Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo

Molecular Therapy: Methods & Clinical Development, 2020
Arginase is a complex and unique enzyme that plays diverse roles in health and disease. By metabolizing arginine, it can shape the outcome of innate and adaptive immune responses. The immunomodulatory capabilities of arginase could potentially be applied
Makan Khoshnejad, Alfredo Perales-Puchalt, Yaya Dia, Peng Xiao, Ami Patel, Ziyang Xu, Xizhou Zhu, Kun Yun, Ishana Baboo, Rehman Qureshi, Laurent Humeau, Kar Muthumani, David B. Weiner   +12 more
doaj   +1 more source

The Effect of Arginase on Canine T-Lymphocyte Functions and its Modulation by All-Trans Retinoid Acid (ATRA) in Canine Monocyte-Derived Macrophages

Veterinary Sciences, 2022
Immunosuppressive myeloid cells in the tumor microenvironment play a major role in suppressing tumor immunity via the production of arginase, IL-10, and others.
Aimee M. Soileau, Cally N. Quick, Cambri E. Moeller, Jessica C. Schaumburg, Sita S. Withers   +4 more
doaj   +1 more source

Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective

International Journal of Molecular Sciences, 2020
Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of hepatic ureogenic function, being widespread through most tissues.
Gonçalo S Clemente, A. van Waarde, Inês F Antunes, A. Dömling, Philip H Elsinga   +4 more
semanticscholar   +1 more source