Results 41 to 50 of about 65,972 (187)
Cascading reaction of arginase and urease on a graphene-based FET for ultrasensitive, real-time detection of arginine [PDF]
, 2018 Herein, a biosensor based on a reduced graphene oxide field effect transistor (rGO-FET) functionalized with the cascading enzymes arginase and urease was developed for the detection of L-arginine.
Azzaroni, Omar +4 more
core +1 more source
Antileishmanial Activity of 4,8-Dimethoxynaphthalenyl Chalcones on Leishmania amazonensis
Antibiotics, 2022 Leishmaniasis is a neglected tropical disease caused by Leishmania species. Available therapeutic options have several limitations. The drive to develop new, more potent, and selective antileishmanial agents is thus a major goal.
Kaio Maciel de Santiago-Silva +13 more
doaj +1 more source
Genetic microheterogeneity and phenotypic variation of arginase in clinical isolates [PDF]
, 2007 Background: Clinical isolates of the gastric pathogen Helicobacter pylori display a high level of genetic macro- and microheterogeneity, featuring a panmictic, rather than clonal structure. The ability of H.
Bathala, Sangeetha +8 more
core +2 more sources
Disturbance of Arginase Activity and Nitric Oxide Levels in Iraqi Type 2 Diabetes Mellitus
مجلة بغداد للعلوم, 2018 This study is an attempt to find whether arginine metabolism dysregulation by arginase activity is related to hyperglycemia, followed by changes in nitric oxide (NO) generation in type 2 diabetic patients. This study includes 42 control subjects (Group I)
Baghdad Science Journal
doaj +1 more source
Experimental Biology and Medicine, 1980 SummaryMouse peritoneal macrophages in culture released a macromolecular factor capable of inhibiting mouse L1210 lymphoma cells in vitro. The factor was proved to be arginase by several criteria. The inhibition was reversed by adding arginine or citrulline to culture, the arginine in the culture medium was consumed, and the guanido group of arginine ...
Chen, P C, Broome, J D
openaire +2 more sources
Mechanisms involved in the remyelinating effect of sildenafil [PDF]
, 2018 Remyelination occurs in demyelinated lesions in multiple sclerosis (MS) and pharmacological treatments that enhance this process will critically impact the long term functional outcome in the disease.
Díaz-Lucena, Daniela +5 more
core +1 more source
Journal of Translational Medicine, 2003 Background Arginine metabolism in tumor cell lines can be influenced by various cytokines, including recombinant human interferon-γ (rIFN-γ), a cytokine that shows promising clinical activity in epithelial ovarian cancer (EOC).
Gallardo Stacie T +5 more
doaj +1 more source
Experimental Biology and Medicine, 1957 SummarySerum arginase activity has been determined in 34 healthy blood donors. A mean value 0.06 ± 0.09 μmole urea formed/ml serum was found with a range of .00 to 0.36 μmole. In sera of 19 patients with proven or suspected liver disease the mean arginase activity was 1.36 with a range of .00 to 6.08 μmoles formed/ml serum under the condition of assay.
R T, MANNING, S, GRISOLIA
openaire +2 more sources
Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models [PDF]
, 2017 Purpose: Glioblastoma multiforme (GBM) is the most aggressive brain tumor. The activity of vosaroxin, a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, was investigated in GBM preclinical models as a ...
Colapietro, Alessandro +11 more
core +1 more source
Erythrocytes as Carriers of Therapeutic Enzymes. [PDF]
, 2020 Therapeutic enzymes are administered for the treatment of a wide variety of diseases. They exert their effects through binding with a high affinity and specificity to disease-causing substrates to catalyze their conversion to a non-noxious product, to ...
Bax, BE
core +1 more source