Results 41 to 50 of about 78,666 (255)

Frequent adaptive immune responses against arginase-1

OncoImmunology, 2018
The enzyme arginase-1 reduces the availability of arginine to tumor-infiltrating immune cells, thus reducing T-cell functionality in the tumor milieu. Arginase-1 is expressed by some cancer cells and by immune inhibitory cells, such as myeloid-derived ...
Evelina Martinenaite, Rasmus Erik Johansson Mortensen, Morten Hansen, Morten Orebo Holmström, Shamaila Munir Ahmad, Nicolai Grønne Dahlager Jørgensen, Özcan Met, Marco Donia, Inge Marie Svane, Mads Hald Andersen   +9 more
doaj   +1 more source

POLARIZED ACTIVATION OF HUMAN PERIPHERAL BLOOD PHAGOCYTES BY BACTERIOPHAGE–DERIVED DOUBLE-STRANDED RNA (LARIFAN) IN VITRO [PDF]

Biotechnologia Acta, 2023
Aim. This study aimed to examine the effect of Larifan on metabolic characteristics of human blood monocytes and granulocytes in vitro. Methods. Four healthy adult men aged 21-26 years were recruited to participate in the study as blood donors.
R. Dovhyi, M. Rudyk, Ye. Hurmach, T. Serhiichuk, Yu. Yumyna, A. Dvukhriadkina, K. Ostrovska, D. Pjanova, L. Skivka   +8 more
doaj   +1 more source

Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease [PDF]

, 2018
The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin on the substantia nigra (SN),
Boza-Serrano, Antonio,, de Pablos, Rocío M.,, Deierborg, Tomas,, Espinosa-Oliva, Ana M.,, García-Domínguez, Irene,, Herrera, Antonio J.,, Ismaiel, Afrah Abdul,, Lund University., Lund University., Machado, Alberto,, Tayara, Khadija,, Venero, José L.,   +11 more
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Evaluation of optimal conditions for arginase activity in streptozotocin induced diabetic rats

Veterinární Medicína, 2005
The assay conditions needed to achieve maximal activity of liver and kidney arginase in diabetic and non-diabetic rats were investigated and compared.
M. Erisir, E. Ercel, S. Yilmaz, S. Ozan
doaj   +1 more source

Arginine to ornithine ratio as a diagnostic marker in patients with positive newborn screening for hyperargininemia

Molecular Genetics and Metabolism Reports, 2021
Arginase deficiency is a rare inborn error of metabolism that interrupts the final step of the urea cycle. Untreated individuals often present with episodic hyperammonemia, developmental delay, cognitive impairment, and spasticity in early childhood. The
Yue Huang, Rajesh Sharma, Annette Feigenbaum, Chung Lee, Inderneel Sahai, Rossana Sanchez Russo, Juanita Neira, Susan Sklower Brooks, Kelly E. Jackson, Derek Wong, Stephen Cederbaum, Felicitas L. Lacbawan, Charles M. Rowland, Pranoot Tanpaiboon, Denise Salazar   +14 more
doaj   +1 more source

Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice [PDF]

, 2019
We investigated the contribution of human platelets to macrophage effector properties in the presence of lipopolysaccharide (LPS), as well as the beneficial effects and time frame for platelet transfusion in septic animals.
Carestia, Agostina, Carrera Silva, Eugenio Antonio, Errasti, Andrea Emilse, Gomez, Ricardo Martin, Jenne, Craig N., Mena, Hebe Agustina, Negrotto, Soledad, Olexen, Cinthia Mariel, Ortiz Wilczyñski, Juan Manuel, Schattner, Mirta Ana   +9 more
core   +1 more source

Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy. [PDF]

, 2014
Hyperammonemia is less severe in arginase 1 deficiency compared with other urea cycle defects. Affected patients manifest hyperargininemia and infrequent episodes of hyperammonemia. Patients typically suffer from neurological impairment with cortical and
Cantero, G, Cantero-Nieto, G, Cederbaum, SD, Chan, E, Hu, C, Lipshutz, GS, Park, H, Tai, DS, Yudkoff, M   +8 more
core   +2 more sources

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

Journal of Immunotherapy for Cancer, 2017
BackgroundMyeloid cells are an abundant leukocyte in many types of tumors and contribute to immune evasion. Expression of the enzyme arginase 1 (Arg1) is a defining feature of immunosuppressive myeloid cells and leads to depletion of L-arginine, a ...
S. Steggerda, M. Bennett, Jason J. Chen, E. Emberley, Tony T. Huang, J. Janes, Weiqun Li, A. Mackinnon, A. Makkouk, G. Marguier, P. Murray, S. Neou, Alison Pan, F. Parlati, Mirna L. M. Rodriguez, Lee-Ann Van de Velde, Tracy Wang, Melissa G. Works, Jing Zhang, Winter Zhang, M. Gross   +20 more
semanticscholar   +1 more source

Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity

Cellular and Molecular Life Sciences, 2020
This study shows that melanoma-associated fibroblasts (MAFs) suppress cytotoxic T lymphocyte (CTL) activity and reveals a pivotal role played by arginase in this phenomenon.
B. Érsek, P. Silló, Uğur Çakır, V. Molnar, A. Bencsik, Balázs Mayer, É. Mezey, S. Kárpáti, Z. Pós, K. Nemeth   +9 more
semanticscholar   +1 more source

Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88 [PDF]

, 2017
This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, grant numbers 11/15682-4, 12/02270-2, 15/18121-4), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Regenera INCT Process Grant 465656/2014-5 ...
Aguiar, Cristhiane Favero, Albuquerque, José Antonio T., Almeida, Rafael Ribeiro, Amano, Mariane Tami, Andrade-Oliveira, Vinicius, Belchior, Thiago, Braga, Tarcio Teodoro, Brown, Gordon D, Castoldi, Angela, Câmara, Niels Olsen Saraiva, da Silva, Marina Burgos, Festuccia, Willian T., Gaiarsa, Jonas W., Hiyane, Meire Ioshie, Hoffmann, Christian, Ignácio, Aline, Latância, Marcela Teatin, Lee, Jennifer, Lima, Joanna Darck Carola C., Loures, Flávio V, Macêdo, Marina Barguil, Martínez, Luis A. Luévano, Miyagi, Marcelli Terumi, Moraes-Vieira, Pedro Manoel, Mori, Marcelo A., Seelaender, Marília   +25 more
core   +5 more sources