Results 71 to 80 of about 65,972 (187)

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α. [PDF]

, 2018
Spatiotemporal regulation of tumor immunity remains largely unexplored. Here we identify a vascular niche that controls alternative macrophage activation in glioblastoma (GBM).
Brem, Steven, Dahmane, Nadia, Duan, Hao, Fan, Yi, Gong, Yanqing, He, Zhenqiang, Hidalgo, Juan, Huang, Menggui, Liu, Tianrun, Ma, Peihong, Mou, Yonggao, O'Rourke, Donald M, Wang, Qirui, Wang, Yanling, Xu, Haineng, Zamvil, Scott S, Zhang, Lin, Zhang, Zhenfeng   +17 more
core   +3 more sources

RETRACTED: Arginase II - a new target in the development of endothelium protectors

Регуляторные исследования и экспертиза лекарственных средств, 2018
RETRACTED ARTICLEThe article describes arginase’s role in pathogenesis of endothelial dysfunction and a number of cardio-vascular diseases. Arginase catalyzes the hydrolysis of L-arginine, the substrate for nitric oxide synthesis, to L-ornithine and urea.
V. I. Yakushev, M. V. Pokrovsky, E. A. Beskhmelnitsyna, O. V. Myasishcheva, A. S. Litvinova, I. I. Krivoshapova, S. A. Demchenko   +6 more
doaj  

Orotic Aciduria [PDF]

, 2018
Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid.
Fonteh, Aliah L
core   +1 more source

Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells. [PDF]

, 2016
Pluripotent stem cells offer great therapeutic promise for personalized treatment platforms for numerous injuries, disorders, and diseases. Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene maintaining pluripotency and self-renewal ...
Awe, Jason P, Byrne, James A, Chang, Katherine M, Hermann, Kip J, Lee, Patrick C, Lipshutz, Gerald S, Schoenberg, Benjamen E, Truong, Brian, Vega-Crespo, Agustin, Wu, Lily   +9 more
core   +3 more sources

Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite

Frontiers in Immunology, 2019
Immunity to intestinal helminths is known to require both innate and adaptive components of the immune system activated along the Type 2 IL-4R/STAT6-dependent pathway.
Kara J. Filbey, Fumi Varyani, Fumi Varyani, Yvonne Harcus, James P. Hewitson, Danielle J. Smyth, Henry J. McSorley, Alasdair Ivens, Susanne Nylén, Martin Rottenberg, Stephan Löser, Rick M. Maizels   +11 more
doaj   +1 more source

Perinatal Gene Transfer to the Liver [PDF]

, 2011
The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within
Buckley, SM, Chan, JK, Howe, SJ, McKay, TR, Rahim, AA, Waddington, SN, Ward, NJ   +6 more
core   +1 more source

Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries [PDF]

, 2009
Objective—Arginase stimulates the proliferation of cultured vascular smooth muscle cells (VSMCs); however, the influence of arginase on VSMC growth in vivo is not known.
Azam, Mohammed A., Durante, William, Ensenat, Diana, Kannan, Sankaranarayanan, Keswani, Amit N., Liu, Xiao-Ming, Peyton, Kelly J., Tulis, David A., Wang, Hong   +8 more
core   +1 more source

RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes

Protein & Cell, 2016
Development of alternatively activated (M2) macrophage phenotypes is a complex process that is coordinately regulated by a plethora of pathways and factors.
Julia Foldi, Yingli Shang, Baohong Zhao, Lionel B. Ivashkiv, Xiaoyu Hu   +4 more
doaj   +1 more source

Characterization, modeling, and anticancer activity of L.arginase production from marine Bacillus licheniformis OF2

BMC Biotechnology
Background L-arginase, is a powerful anticancer that hydrolyzes L-arginine to L-ornithine and urea. This enzyme is widely distributed and expressed in organisms like plants, fungi, however very scarce from bacteria.
Manal S. Selim, Marwa M. Mounier, Sayeda A. Abdelhamid, Ahmed Abdelghani Hamed, Mostafa M. Abo Elsoud, Sahar S. Mohamed   +5 more
doaj   +1 more source

Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline [PDF]

, 2009
Background: Pharmacological inhibition of endothelial arginase-II has been shown to improve endothelial nitric oxide synthase (eNOS) function and reduce atherogenesis in animal models.
Xiu-Fen Ming, Angana Gupta Rajapakse, João Miguel Carvas, Jean Ruffieux, Zhihong Yang, R Ross, P Libby, S Blankenberg, KD O'Brien, MJ Davies, MI Cybulsky, HM Dansky, MC Bourdillon, K Kitagawa, ZM Dong, RM Palmer, Z Yang, DN Granger, T Michel, DT Engelman, K Kobayashi, Z Yang, XF Ming, S Ryoo, XF Ming, XF Ming, H Shima, MA Read, NS Holden, KN Anwar, RJ Shi   +30 more
core   +2 more sources