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Pegylated Arginine Deiminase Drives Arginine Turnover and Systemic Autophagy to Dictate Energy Metabolism [PDF]
Cell Reports Medicine, 2022 Obesity is a multi-systemic disorder of energy balance. Despite intense investigation, the determinants of energy homeostasis remain incompletely understood, and efficacious treatments against obesity and its complications are lacking.
Yiming Zhang +2 more
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Arginine Deiminase, a Potential Anti-Tumor Drug
Cancer Letters, 2008Arginine deiminase (ADI; EC 3.5.3.6), an arginine-degrading enzyme, has been studied as a potential anti-tumor drug for the treatment of arginine-auxotrophic tumors, such as hepatocellular carcinomas (HCCs) and melanomas. Studies with human lymphatic leukemia cell lines further suggest that ADI is a potential anti-angiogenic agent and is effective in ...
Ulrich Schwaneberg, Ye Ni, Zhi-Hao Sun
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Arginine Deiminase: Current Understanding and Applications
Recent Patents on Biotechnology, 2019Background:Arginine deiminase (ADI), an arginine catabolizing enzyme, is considered as an anti-tumor agent for the treatment of arginine auxotrophic cancers. However, some obstacles limit its clinical applications.Objective:This review will summarize the clinical applications of ADI, from a brief history to its limitations, and will discuss the ...
Mahboubeh, Zarei +6 more
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Peptidyl Arginine Deiminases and Neurodegenerative Diseases
Current Medicinal Chemistry, 2016Peptidyl arginine deiminases (PADs) are a small group of isozymes that convert Arg residues on the surface of proteins into citrulline residues, typically as a part of posttranslational processing. PADs are present in most of the tissues, and the isozyme distribution is tissue-specific. In the past 15 years, it is becoming apparent that PADs are either
R, Tu, H M, Grover, L P, Kotra
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Novel Arginine Deiminase-Based Method to Assay l-Arginine in Beverages
Food Chemistry, 2016A highly selective and sensitive enzymatic method for the quantitative determination of L-arginine (Arg) has been developed. The method is based on the use of recombinant bacterial arginine deiminase (ADI) isolated from the cells of a recombinant strain Escherichia coli and o-phthalaldehyde (OPA) as a chemical reagent.
Galina Z Gayda
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Evolution of arginine deiminase (ADI) pathway genes
Molecular Phylogenetics and Evolution, 2002We have analyzed the evolution of the three genes encoding structural enzymes of the arginine deiminase (ADI) pathway, arginine deiminase (ADI), ornithine transcarbamoylase (OTC), and carbamate kinase (CK) in a wide range of organisms, including Archaea, Bacteria, and Eukarya. This catabolic route was probably present in the last common ancestor to all
Manuel, Zúñiga +2 more
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Catalysis by arginine deiminase: Evidence for a covalent intermediate
Biochemical and Biophysical Research Communications, 1978Abstract Arginine deiminase (EC 3.5.3.6) catalyzes the hydrolysis of arginine to ammonia and citrulline. This reaction is postulated to occur in three steps: (1) formation of the Michaelis complex, (2) the formation of an amidino-enzyme intermediate and liberation of ammonia, and (3) the rate-determining step, hydrolysis of the amidino-enzyme.
D W, Smith, D E, Fahrney
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Directed arginine deiminase evolution for efficient inhibition of arginine-auxotrophic melanomas
Applied Microbiology and Biotechnology, 2014Arginine deiminase (ADI) is a therapeutic protein for cancer therapy of arginine-auxotrophic tumors. However, ADI's application as anticancer drug is hampered by its low activity for arginine under physiological conditions mainly due to its high "K M" (S₀.₅) values which are often 1 magnitude higher than the arginine concentration in blood (0.10-0.12 ...
Feng, Cheng +4 more
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[36] Arginine deiminase (Mycoplasma)
1970Publisher Summary This chapter presents the assay, purification, and properties of arginine deiminase. Certain strains of Mycoplasma are exceedingly rich sources of the enzymes of the arginine dihydrolase pathway that includes arginine deiminase, ornithine transcarbamylase, and carbamate kinase.
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