Results 51 to 60 of about 27,759 (158)

Unstable argininosuccinate lyase in variant forms of the urea cycle disorder argininosuccinic aciduria. [PDF]

, 2015
Loss of function of the urea cycle enzyme argininosuccinate lyase (ASL) is caused by mutations in the ASL gene leading to ASL deficiency (ASLD). ASLD has a broad clinical spectrum ranging from life-threatening severe neonatal to asymptomatic forms ...
Häberle, Johannes, Eggimann, Sandra, Balmer, Cécile, Sandra Eggimann, Pandey, Amit Vikram, Liyan Hu, Rüfenacht, Véronique, Johannes Häberle, Véronique Rüfenacht, Amit V. Pandey, Pandey, Amit V, Jean‐Marc Nuoffer, Nuoffer, Jean-Marc, Cécile Balmer, Hu, Liyan, Eggimann S, Balmer C, Rüfenacht V, Häberle J, Pandey AV, Nuoffer JM, Hu L   +21 more
core   +2 more sources

Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers

Biomolecules, 2021
There is a pressing need for molecular targets and biomarkers in gastric cancer (GC). We aimed at identifying aberrations in L-arginine metabolism with therapeutic and diagnostic potential.
Iwona Bednarz-Misa, Mariusz G. Fleszar, Paulina Fortuna, Łukasz Lewandowski, Magdalena Mierzchała-Pasierb, Dorota Diakowska, Małgorzata Krzystek-Korpacka   +6 more
doaj   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Genetic Engineering Efforts to Generate Chlamydomonas Strains for Large‐Scale Biomolecule Production

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
This represents the main aspects relevant to potential industrialization of Chlamydomonas. ABSTRACT Chlamydomonas reinhardtii is an established model microalga. Its easy manipulation, metabolic flexibility and tractable genomes allowed researchers to investigate fundamental processes such as photosynthesis using genetic studies for decades ...
Sofia Inturri, Nicolas Rouhier, Claire Remacle   +2 more
wiley   +1 more source

Gene expression analysis of the L-arginine pathway in renal cell carcinoma [PDF]

BIO Web of Conferences
Objective: To explore the key genes and their expression profiles in L-arginine biosynthesis and metabolic pathways in renal cell carcinoma (RCC) using bioinformatics methods.
Yang Yu, Liu Hongde
doaj   +1 more source

Finding My Path: Listening, Learning, and Leading in Rare Disease: The 2025 Hower Award

Annals of the Child Neurology Society, EarlyView.
Andrea Gropman
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Mutational analysis of amino acid residues involved in argininosuccinate lyase activity in duck [delta] II crystallin

, 1998
grantor: University of Toronto[delta] crystallins are the major structural eye lens protein of most birds and reptiles and are direct homologues of the urea cycle enzyme argininosuccinate lyase.
Chakraborty, Anita Rupali
core   +1 more source

Interference with the citrulline-based nitric oxide synthase assay by argininosuccinate lyase activity in Arabidopsis extracts

, 2007
There are many reports of an arginine-dependent nitric oxide synthase activity in plants; however, the gene(s) or protein(s) responsible for this activity have yet to be convincingly identified.
Tischner, R., Mack, A., Tischner, Rudolf, Heimer, Y., Galli, M., Crawford, Nigel M., Galli, Mary, Bielefeld, S., Heimer, Yair M., Okamoto, Mamoru, Crawford, N., Bielefeld, Sarah, Mack, Alyson, Okamoto, M.   +13 more
core   +1 more source

Expression pattern and biochemical properties of zebrafish N-acetylglutamate synthase. [PDF]

PLoS ONE, 2014
The urea cycle converts ammonia, a waste product of protein catabolism, into urea. Because fish dispose ammonia directly into water, the role of the urea cycle in fish remains unknown.
Ljubica Caldovic, Nantaporn Haskins, Amy Mumo, Himani Majumdar, Mary Pinter, Mendel Tuchman, Alison Krufka   +6 more
doaj   +1 more source