Results 61 to 70 of about 27,759 (158)
Fumarate and Its Esters: Physiology, Pathology, Molecular Mechanisms, Diseases, and Therapy
MedComm, Volume 7, Issue 10, October 2026.Fumarate is an endogenous immunometabolite that regulates metabolism, redox homeostasis, and inflammation. Although fumaric acid esters (FAEs) share several molecular targets with fumarate, their distinct physicochemical properties confer unique biological activities and therapeutic applications.
Peng Zhu +6 more
wiley +1 more source
Respiratory Research, 2012 Background Hyperoxia is shown to impair airway relaxation via limiting L-arginine bioavailability to nitric oxide synthase (NOS) and reducing NO production as a consequence. L-arginine can also be synthesized by L-citrulline recycling.
Sopi Ramadan B +7 more
doaj +1 more source
New Phytologist, Volume 252, Issue 1, Page 145-162, October 2026.Long‐read whole‐genome sequencing revealed extensive chromosomal rearrangements and aneuploidy in a widely used Chlamydomonas reinhardtii stt7‐1 mutant. The STT7 gene (shown in red) was found to be split between two rearranged chromosomes, providing a molecular explanation for the long‐standing failure of this mutant in genetic crosses.
Sandrine Bujaldon +3 more
wiley +1 more source
, 2019 Argininosuccinate lyase catalyses the reversible breakdown of argininosuccinate into arginine and fumarate and is known to form tetramers in its quaternary association.
Paul, Anju +3 more
core +1 more source
Amino Acid Metabolism in Health and Disease
MedComm, Volume 7, Issue 9, September 2026.This graphical abstract delineates the multifaceted role of amino acid metabolism in health and disease. It illustrates how amino acids sustain physiological homeostasis across the liver, kidney, brain, heart, intestine, muscle, skeleton, and immune system.
Zhiwei Su +7 more
wiley +1 more source
The pathway for urea cycle derived from KEGG pathway analysis.
, 2016 UM_WWY possess a gene encoding for a putative enzyme arginase (EC 3.5.3.1) which hydrolyzes arginine into ornithine and urea. EC 6.3.4.5 = Argininosuccinate synthetase; EC 4.3.2.1 = Argininosuccinate lyase; EC 2.1.3.3 = Ornithine transcarbamoylase.
Tze King Tan (2587147) +3 more
core +1 more source
The central metabolism of M. alcaliphilum 20Z.
, 2023 1 –hexulose 6-phosphate synthase, 2 –phosphohexuloisomerase 3 –PPi-dependent 6-phosphofructokinase, 4 –glyceraldehyde-3-phosphate dehydrogenase, 5 –pyruvate dehydrogenase complex, 6 –citrate synthase, 7 –aconitase, 8 –isocitrate dehydrogenase, 9 – α ...
Valentina N. Khmelenina (7878662) +6 more
core +1 more source
Management of a urea cycle disorder in the setting of socioeconomic and language barriers
Molecular Genetics and Metabolism ReportsArgininosuccinic aciduria (ASA) is a disorder that results from a deficiency in the urea cycle enzyme argininosuccinate lyase. Variable manifestations of this hereditary disorder are associated with hyperammonemia and can include lethargy, somnolence ...
Erika Vucko +5 more
doaj +1 more source
Assessing the therapeutic potential of PDE‐5 inhibitors in adults: Insights from a multi‐omics study
Physiological Reports, Volume 14, Issue 18, September 2026.Abstract Phosphodiesterase‐5 inhibitors have beneficial pleiotropic effects and hold promise as adjuvant treatments for cancer, dementia, and other disorders. Sixteen men and women aged 50–60 were administered daily sildenafil/tadalafil for 1 month. We characterized molecular signatures of sildenafil/tadalafil treatment via analyses and multi‐omics ...
Kristen A. McGovern +14 more
wiley +1 more source
The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds
Advanced ScienceThe approach to dealing with chronic wounds is still challenging in clinic. Multitarget drugs have the advantages of superior therapeutic effect and minimal adverse reactions.
Manyu Gong +27 more
doaj +1 more source