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Protein Kinase Cα Phosphorylates a Novel Argininosuccinate Synthase Site at Serine 328 During Calcium-Dependent Stimulation of Endothelial Nitric-Oxide Synthase in Vascular Endothelial Cells *♦ [PDF]
Journal of Biological Chemistry, 2012 Endothelial nitric-oxide synthase (eNOS) utilizes l-arginine as its principal substrate, converting it to l-citrulline and nitric oxide (NO). l-Citrulline is recycled to l-arginine by two enzymes, argininosuccinate synthase (AS) and argininosuccinate ...
Ricci Haines +2 more
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FEBS Journal, 2007 There are many reports of an arginine-dependent nitric oxide synthase activity in plants; however, the gene(s) or protein(s) responsible for this activity have yet to be convincingly identified.
Mamoru Okamoto +2 more
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Argininosuccinate Synthase as a Novel Biomarker for Inflammatory Conditions
Biomarkers, 2013Argininosuccinate synthase (ASS) plays an important role in regulating metabolic functions in mammals. We previously reported that hepatic ASS is released into circulation at very high concentrations in response to endotoxin and acute liver injury. We propose that ASS may serve as a novel biomarker for various inflammatory conditions.
David R. Nelson, Thomas J George
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Phosphorylation of Argininosuccinate Synthase by Protein Kinase A
Biochemical and Biophysical Research Communications, 2008Argininosuccinate synthase (AS) is essential for endothelial nitric oxide (NO) production and its regulation in this capacity has been studied primarily at the transcriptional level. The dynamics of vascular function suggest that an acute regulation system may mediate AS function.
Karen D Corbin +2 more
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Molecular and Cellular Endocrinology, 2014 National Basic Research Program of China [2011CB944402, 2013CB910803]; National Natural Science Foundation of China [31272263]L-Arginine (L-Arg), a conditional essential amino acid in adults, has been shown to enhance pregnancy outcome. Argininosuccinate
Zeng-Ming Yang, Wen-Bo Deng, Ru-Juan Zuo
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Troglitazone Up-Regulates Vascular Endothelial Argininosuccinate Synthase
Biochemical and Biophysical Research Communications, 2008Vascular endothelial nitric oxide (NO) production via the citrulline-NO cycle not only involves the regulation of endothelial nitric oxide synthase (eNOS), but also regulation of caveolar-localized endothelial argininosuccinate synthase (AS), which catalyzes the rate-limiting step of the cycle.
Karen D Corbin +2 more
exaly +3 more sources