Results 121 to 130 of about 115,664,573 (187)

Cerebral H-1 MR spectroscopy showing elevation of brain guanidino acetate in argininosuccinate lyase deficiency

, 2006
MR spectroscopy in a patient with argininosuccinate lyase deficiency revealed elevated cerebral guanidinoacetate signals, indicating that the phenomenon of increased levels of this compound in brain tissue is not limited to creatine deficiencies.
van Spronsen, FJ, Reijngoud, DJ; id_orcid, Soorani-Lunsing, RJ, Oudkerk, M, Oudkerk, M; id_orcid, Sijens, PE, Reijngoud, DJ   +6 more
core   +1 more source

Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism

Frontiers in Molecular Biosciences
We have previously shown that the holocarboxylase synthetase (HLCS) is overexpressed in breast cancer tissue of patients, and silencing of its expression in triple-negative cancer cell line inhibits growth and migration.
Witchuda Sukjoi, Clifford Young, Mitchell Acland, Siraprapa Siritutsoontorn, Sittiruk Roytrakul, Manuela Klingler-Hoffmann, Peter Hoffmann, Sarawut Jitrapakdee   +7 more
doaj   +1 more source

The Trypanosoma brucei sphingolipid synthase, an essential enzyme and a drug target [PDF]

, 2009
Sphingolipids are important structural components of eukaryotic membranes, in addition they and their precursors are involved in signal transduction processes.
Pan, Ssu-Ying
core  

The Role of Argininosuccinate Synthase Serine 328 Phosphorylation in Nitric Oxide Production

, 2012
Until recently, the main mechanism of argininosuccinate synthase (AS) regulation was described to exist mainly at the level of transcription. Transcriptional regulation of AS has been shown to be coordinate with eNOS in response to shear stress, hypoxia,
Haines, Ricci
core  

Argininosuccinate Synthase 1 links hepatic urea cycle to whole body lipid metabolism

bioRxiv
Laura C. Kim, Nicholas P. Lesner, Xuan-Yan Cai, Xu Han, Jae Woo, Jimmy P. Xu, Nathan J. Coffey, Denise Zheng, Morgan L. Brown, C. Mesaros, Z. Arany, M. Simon   +11 more
semanticscholar   +1 more source

Detection of homozygous genotypes for a putatively lethal recessive mutation in the porcine argininosuccinate synthase 1 (ASS1) gene

The sequencing of the pig genome revealed the existence of homozygous individuals for a nonsense mutation in the argininosuccinate synthase 1 (ASS1) gene (rs81212146, c.944T>A, L315X).
Quintanilla, Raquel, Amills i Eras, Marcel, Luigi Sierra, Maria Gracia, Mármol-Sánchez, Emilio   +3 more
core  

Metabolic Engineering of Pichia pastoris for S-Adenosylmethionine Overproduction via Transcriptomic-Guided Energy Reallocation. [PDF]

Biotechnol J
Shang YY, Li ZY, Wu JM, Yang H, Lian Z, Zhu HY, Qian JC, Xu F, Huang MZ.   +8 more
europepmc   +1 more source

Metabolic reprogramming-mediated therapeutic resistance in renal cell carcinoma: Mechanisms and targeted intervention strategies. [PDF]

iScience
Wu H, Gan X, Wang S, Wang R, Hu J, Wang L, Shi J.   +6 more
europepmc   +1 more source

Cholestatic Liver Failure and Hypoglycemia in a Newborn: A Mitochondrial Pathology due to Citrin Deficiency. [PDF]

Clin Case Rep
Neveu J, Butori M, Spraul A, Hinault-Boyer C, Naïmi M.   +4 more
europepmc   +1 more source

Citrin Deficiency: Biochemical Mechanisms Underlying a Complex Hepatic Metabolic Disorder. [PDF]

Biomolecules
García-Lobo I, Del Arco A, Satrústegui J, Contreras L.   +3 more
europepmc   +1 more source