Results 111 to 120 of about 115,664,573 (187)

Absolute abundances of transcripts related to N assimilation pathway and the urea cycle.

, 2014
The transcript abundance that was obtained from RNA-seq data is indicated as RPKM (see Methods). The abundance of NasB transcript is shown on the right Y axis, while that of other transcripts is shown on the left Y axis.
Jing-Yi Cen (648108), Kai-Xuan Huang (648105), Yue-Lei Dong (648109), Hua-Long Wang (648106), Song-Hui Lu (648107), Hong-Po Dong (648104)   +5 more
core   +1 more source

Circadian disruption promotes epileptic seizures via the Ruminococcus gnavus-arginine-NOX4-ferroptosis axis

Brain Research Bulletin
Circadian rhythm disruption (CRD) exacerbates epileptic seizures, yet the underlying molecular mechanisms remain unclear. Using a pentylenetetrazol (PTZ) kindling rat model combined with continuous light exposure, we found that CRD significantly ...
Fanqi Yu, Jia He, Yan Chen, Yulan Zhu
doaj   +1 more source

Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants

Molecules and Cells
Summary Many types of human cancers suppress the expression of argininosuccinate synthase 1 (ASS1), a rate-limiting enzyme for arginine production. Although dependency on exogenous arginine can be harnessed by arginine-deprivation therapies, the impact ...
Chao Yang, Abhijeet Pataskar, Xiao-Dong Feng, Jasmine Montenegro Navarro, Inés Paniagua, J. Jacobs, E. Zaal, C. Berkers, Onno B. Bleijerveld, R. Agami   +9 more
semanticscholar   +1 more source

Integration of metabolite and transcript data of ornithine-linked pathways.

, 2019
The squares indicate changes on both transcription and metabolic level in response to a CO2-shift from 400 ppm to 100 ppm (Student´s t-test ...
Miriam Laxa (6236678), Marco Mühlenbruch (6236672), Christoph Peterhänsel (6236675), Christian Blume (6236666), Julia Ost (6236669)   +4 more
core   +1 more source

Proteomic analysis reveals potential biomarker candidates in serous ovarian tumors – a preliminary study

Contemporary oncology
Introduction Ovarian serous cystadenocarcinoma (SCA), a deadly gynecologic cancer, often goes undetected until the late stages. Tissue proteomics unveils disease heterogeneity, enhancing tumor classification and enabling personalized treatments tailored ...
Shona Pedersen, Alaaeldin Ali Mohamed, H. Krzyslak, Latifa A AlKaabi, M. A. AbuHaweeleh, Ala-Eddin Al Moustafa, L. Ghabreau, S. Vranić, B. Honoré   +8 more
semanticscholar   +1 more source

Application of humanized mice to toxicology studies: properties of chimeric mice with humanized liver (PXB-mice) for hepatotoxicity

Journal of Toxicologic Pathology
Chimeric mice with humanized liver are considered a useful tool to predict drug pharmacokinetics and in vivo toxicity in humans. The PXB-mouse is one of such chimeric (humanized) mouse models with more than 70% of human hepatocytes in their liver, which ...
N. Sultana, Takeshi Izawa, Tomomi Kamei, Sho Fujiwara, Yuri Ito, Yuki Takami, Mitsuru Kuwamura   +6 more
semanticscholar   +1 more source

Arginine restriction exploits DNMT3B-ASS1-driven arginine auxotrophy and mTORC1-suppressed autophagy to overcome niraparib resistance in ovarian cancer.

Cancer Letters
Acquired resistance to poly(ADP-ribose) polymerase (PARP) inhibitors limits the durability of niraparib maintenance therapy in epithelial ovarian cancer.
Hao-Yu Wang, Xin-Qi Wang, Wen-Yi Zhang, Siyuan Hu, Hui-Yu Chen, Jing-Chun Liu, Hong-Yang Xue, Jiang Yang, Yuan Li, Dan Wang, Chen Li, Ming Du, Zhen Zheng, Jia-Yuan Zhao, Reyilanmu Maisaidi, Chengzhi Liu, Yang Xiang, Li-Zhi Hong   +17 more
semanticscholar   +1 more source

Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice

, 2012
Background and Aim: Argininosuccinate synthase (ASS) is the rate-limiting enzyme in both the urea and the l-citrulline/nitric oxide (NO·) cycles regulating protein catabolism, ammonia levels and NO· generation (1-2).
Ward, Stephen C., Ge, Xiaodong, Leung, Tung Ming, Yan, Wei, de la Rosa, Laura Conde, Lu, Yongke, Morón‐Concepción, José A., Nieto, Natalia   +7 more
core  

ASS1 Promotes Atherosclerotic Inflammation Through the NLRP3/IL-33/ST2 Axis in Ox-LDL-Induced Foam Cells.

Frontiers in Bioscience
BACKGROUND Atherosclerosis is a chronic inflammatory disease characterized by lipid-driven immune dysregulation. Argininosuccinate synthase 1 (ASS1) has been implicated in macrophage inflammation, yet its precise mechanistic role in foam cell-mediated ...
Shao-Yu Wu, Fei-Huang Han, Z. Qiao, Sheng Yuan, X. Bian, Bin Zhang, K. Dou, Dun-Liang Ma   +7 more
semanticscholar   +1 more source

Glucan synthase of Phytophthora sojae [PDF]

, 2002
Glucans, with the (1-3)-b-glucosidic linkage as major feature, are present in most of the higher plants, in many lower plants, as well as in microorganisms (Stone and Clarke, 1992). The synthesis of (1-3)-b-glucan in vivo is catalysed by the enzyme (1-3)-
Antelo, Luis
core   +1 more source