Results 91 to 100 of about 115,664,573 (187)

Insights into the dynamic cell associated and secreted proteome of Staphylococcus aureus cultured in TSB and milk media: a proteomic analysis

BMC Microbiology
The availability of nutrients is closely linked to the protein expression profile of microorganisms. In this study, a comparative investigation has been performed to examine the expression patterns of cell associated proteins and secreted proteins in ...
Wanting Zhu, Yujing Wang, Yanxin Li, Changjiang Zang, Hongning Jiang, Qijing Du, Jun Wang, Rongbo Fan, Rongwei Han, Yongxin Yang   +9 more
doaj   +1 more source

ASS1 inhibits liver cancer by promoting CAD ubiquitination and reversing the urea cycle and pyrimidine synthesis imbalance. [PDF]

Hepatol Commun
Background: The urea cycle and pyrimidine synthesis occur mainly in the liver and undergo opposite changes during hepatocarcinogenesis. Argininosuccinate synthase 1 (ASS1) and carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and ...
Ming Z, Luo T, Zou Z, Luo W, Hu X, Chen L, Zhou J, Liu X, Liu M, Li J, Luo J, Ma D, Liu S, Luo Z.   +13 more
europepmc   +2 more sources

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Gene expression of selected genes in liver of rats after 50 weeks of diet administration¹.

, 2013
Abbreviations: TTA, tetradecylthioacetic acid; FO, fish oil; Aldh9a1, aldehyde dehydrogenase 9, subfamily A1; Bbox1, gamma-butyrobetaine hydroxylase 1; Tmlhe, trimethyllysine hydroxylase, epsilon; Aox3, aldehyde oxidase 3; Clpx, ClpX caseinolytic ...
Trond Brattelid (290970), Gard Frodahl Tveitevåg Svingen (425677), Ottar Nygård (425679), Asbjørn Svardal (425678), Elin Strand (425675), Natalya Filipchuk Vigerust (425676), Bodil Bjørndal (116118), Rolf Kristian Berge (116124)   +7 more
core   +1 more source

Fumarate and Its Esters: Physiology, Pathology, Molecular Mechanisms, Diseases, and Therapy

MedComm, Volume 7, Issue 10, October 2026.
Fumarate is an endogenous immunometabolite that regulates metabolism, redox homeostasis, and inflammation. Although fumaric acid esters (FAEs) share several molecular targets with fumarate, their distinct physicochemical properties confer unique biological activities and therapeutic applications.
Peng Zhu, Mengling You, Yi Zeng, Jinglin Zhang, Si Chen, Rong Rong, Xiaobo Xia   +6 more
wiley   +1 more source

Polynucleotides targeted against the extended 5′-UTR region of argininosuccinate synthase and uses thereof

, 2010
The present invention is based in part on the discovery that the upstream open reading frame (uORF) in the extended 5′-untranslated region (5′-UTR) argininosuccinate synthase (AS) mRNA species is functional, and when functional, limits overall AS ...
Pendleton, Laura C., Solomonson, Larry P., Eichler, Duane C.   +2 more
core  

The Role and Regulation of Argininosuccinate Synthase in Endothelial Function

, 2005
While cellular levels of arginine greatly exceed the apparent Km for endothelial nitric oxide synthase (eNOS), nitric oxide (NO) production is limited by availability of arginine. Results from this work have provided a unique understanding of endothelial
Goodwin, Bonnie L
core  

Mutations and polymorphisms in the human argininosuccinate lyase (ASL) gene [PDF]

, 2014
Argininosuccinate lyase deficiency (ASLD) is caused by a defect of the urea cycle enzyme argininosuccinate lyase (ASL) encoded by the ASL gene. Patients often present early after birth with hyperammonemia but can also manifest outside the neonatal period
Rüfenacht, Véronique, Wong, Lee-Jun, Häberle, Johannes, Pandey, Amit V, Nuoffer, Jean-Marc, Balmer, Cécile, Pandey, Amit Vikram, Fang, Ping, Wong LJ, Balmer C, Rüfenacht V, Häberle J, Pandey AV, Nuoffer JM, Fang P   +14 more
core   +1 more source

Keystone microbial isozyme enhances crustacean growth by utilizing L-citrulline

Microbiome
Background Under standardized rearing conditions, the genetically uniform “Keyong No. 1” swimming crab exhibits pronounced inter-individual variability in growth performance.
Weichuan Lin, Mingming Niu, Ye Sun, Wenkai Yu, Ronghua Li, Changkao Mu, Chunlin Wang, Limin Zhang, Jizhong Zhou, Yangfang Ye   +9 more
doaj   +1 more source

Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture [PDF]

, 2004
Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric oxide synthase
Damian J Murphy, Dunmore, Simon J., Murphy Damian J, Carson Ray J, Rodrigo, Nalinda, Seyffarth Gunter, Nelson, Paul N., Dunmore Simon J, Simon J Dunmore, Nalinda Rodrigo, Carson, Ray J., Seyffarth, Gunther, Rodrigo Nalinda, Paul N Nelson, Murphy, Damian J., Nelson Paul N, Gunter Seyffarth, Ray J Carson   +17 more
core   +1 more source